Q06587: E3 ubiquitin-protein ligase RING1

General Information

Protein names	- E3 ubiquitin-protein ligase RING1 - 2.3.2.27 - Polycomb complex protein RING1 - RING finger protein 1 - RING-type E3 ubiquitin transferase RING1 {ECO:0000305} - Really interesting new gene 1 protein
Gene names	RING1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q06587

9 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MTTPANAQNA SKTWELSLYE LHRTPQEAIM DGTEIAVSPR SLHSELMCPI CLDMLKNTMT
        70         80         90        100        110        120
TKECLHRFCS DCIVTALRSG NKECPTCRKK LVSKRSLRPD PNFDALISKI YPSREEYEAH
       130        140        150        160        170        180
QDRVLIRLSR LHNQQALSSS IEEGLRMQAM HRAQRVRRPI PGSDQTTTMS GGEGEPGEGE
       190        200        210        220        230        240
GDGEDVSSDS APDSAPGPAP KRPRGGGAGG SSVGTGGGGT GGVGGGAGSE DSGDRGGTLG
       250        260        270        280        290        300
GGTLGPPSPP GAPSPPEPGG EIELVFRPHP LLVEKGEYCQ TRYVKTTGNA TVDHLSKYLA
       310        320        330        340        350        360
LRIALERRQQ QEAGEPGGPG GGASDTGGPD GCGGEGGGAG GGDGPEEPAL PSLEGVSEKQ
       370        380        390        400
YTIYIAPGGG AFTTLNGSLT LELVNEKFWK VSRPLELCYA PTKDPK

Isoforms

- Isoform 2 of E3 ubiquitin-protein ligase RING1

Sequence View

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Protein Neighborhood

Domains & Features

9 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q06587-1-unknown	MTTPAN...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q06587-30-unknown	MDGTEI...	30	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt87772
Q06587-32-unknown	GTEIAV...	32	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt171950
Q06587-32-	GTEIAV...	32		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q06587-32-	GTEIAV...	32		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q06587-89-unknown	KKLVSK...	89	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11929
Q06587-89-unknown	KKLVSK...	89	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt139930
Q06587-96-unknown	SLRPDP...	96	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt174196
Q06587-96-	SLRPDP...	96		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q06587-190-unknown	SAPDSA...	190	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt174194
Q06587-190-	SAPDSA...	190		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...CPTCRK	88	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11929
...CPTCRK	88	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt123035
...TKDPK	406	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...TKDPK	406	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt83390

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	88	TCRK.\|.KKLV	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)