Q07820: Induced myeloid leukemia cell differentiation protein Mcl-1

General Information

Protein names	- Induced myeloid leukemia cell differentiation protein Mcl-1 - Bcl-2-like protein 3 - Bcl2-L-3 - Bcl-2-related protein EAT/mcl1 - mcl1/EAT
Gene names	MCL1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q07820

9 N-termini

4 C-termini

6 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MFGLKRNAVI GLNLYCGGAG LGAGSGGATR PGGRLLATEK EASARREIGG GEAGAVIGGS
        70         80         90        100        110        120
AGASPPSTLT PDSRRVARPP PIGAEVPDVT ATPARLLFFA PTRRAAPLEE MEAPAADAIM
       130        140        150        160        170        180
SPEEELDGYE PEPLGKRPAV LPLLELVGES GNNTSTDGSL PSTPPPAEEE EDELYRQSLE
       190        200        210        220        230        240
IISRYLREQA TGAKDTKPMG RSGATSRKAL ETLRRVGDGV QRNHETAFQG MLRKLDIKNE
       250        260        270        280        290        300
DDVKSLSRVM IHVFSDGVTN WGRIVTLISF GAFVAKHLKT INQESCIEPL AESITDVLVR
       310        320        330        340        350
TKRDWLVKQR GWDGFVEFFH VEDLEGGIRN VLLAFAGVAG VGAGLAYLIR

Isoforms

- Isoform 2 of Induced myeloid leukemia cell differentiation protein Mcl-1

Sequence View

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Protein Neighborhood

Domains & Features

9 N-termini - 4 C-termini - 6 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q07820-1-acetylation	MFGLKR...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q07820-1-acetylation	MFGLKR...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q07820-1-acetylation	MFGLKR...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162661
Q07820-1-unknown	MFGLKR...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q07820-1-unknown	MFGLKR...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt80621
Q07820-17-unknown	GGAGLG...	17			unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q07820-17-unknown	GGAGLG...	17			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q07820-17-unknown	GGAGLG...	17		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt159920
Q07820-17-	GGAGLG...	17			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
Q07820-17-	GGAGLG...	17			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q07820-17-	GGAGLG...	17			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q07820-17-	GGAGLG...	17			Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
Q07820-17-	GGAGLG...	17			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q07820-17-	GGAGLG...	17			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q07820-17-	GGAGLG...	17			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q07820-118-unknown	AIMSPE...	118		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2097
Q07820-118-unknown	AIMSPE...	118		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11932
Q07820-118-unknown	AIMSPE...	118		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt143351
Q07820-128-unknown	GYEPEP...	128		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2099
Q07820-128-unknown	GYEPEP...	128		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11934
Q07820-128-unknown	GYEPEP...	128		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt143802
Q07820-158-	GSLPST...	158			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q07820-158-	GSLPST...	158			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q07820-158-	GSLPST...	158			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q07820-158-	GSLPST...	158			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q07820-158-	GSLPST...	158			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q07820-158-unknown	GSLPST...	158		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2101
Q07820-158-unknown	GSLPST...	158		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11936
Q07820-158-unknown	GSLPST...	158		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145063
Q07820-212-unknown	TLRRVG...	212		inferred from electronic annotation	unknown	TISdb		inferred from TISdb

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...APAADA	117	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2097
...APAADA	117	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11932
...APAADA	117	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126583
...EEELDG	127	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2099
...EEELDG	127	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11934
...EEELDG	127	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127044
...NTSTDG	157	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2101
...NTSTDG	157	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11936
...NTSTDG	157	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128345
...AYLIR	350	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP3_HUMAN	117	AADA.\|.AIMS	inferred from experiment	unknown	MEROPS	Rabinowich H	Han J et al.:Disruption of Mcl-1.Bim complex... (C14.003)	15713684,
GRAB_HUMAN	117	AADA.\|.AIMS	inferred from experiment	unknown	MEROPS	Rabinowich H	Han J et al.:Disruption of Mcl-1.Bim complex... (C14.003)	15713684,
CASP3_HUMAN	127	ELDG.\|.GYEP	inferred from experiment	unknown	MEROPS	Tang H	Weng C et al.:Specific cleavage of Mcl-1 by c... (C14.003)	15637055,
GRAB_HUMAN	127	ELDG.\|.GYEP	inferred from experiment	unknown	MEROPS	Rabinowich H	Han J et al.:Disruption of Mcl-1.Bim complex... (C14.003)	15713684,
CASP3_HUMAN	157	STDG.\|.GSLP	inferred from experiment	unknown	MEROPS	Tang H	Weng C et al.:Specific cleavage of Mcl-1 by c... (C14.003)	15637055,
GRAB_HUMAN	157	STDG.\|.GSLP	inferred from experiment	unknown	MEROPS	Rabinowich H	Han J et al.:Disruption of Mcl-1.Bim complex... (C14.003)	15713684,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)