Q12931: Heat shock protein 75 kDa, mitochondrial

General Information

Protein names	- Heat shock protein 75 kDa, mitochondrial - HSP 75 - TNFR-associated protein 1 - Tumor necrosis factor type 1 receptor-associated protein - TRAP-1
Gene names	TRAP1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q12931

6 N-termini

4 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MARELRALLL WGRRLRPLLR APALAAVPGG KPILCPRRTT AQLGPRRNPA WSLQAGRLFS
        70         80         90        100        110        120
TQTAEDKEEP LHSIISSTES VQGSTSKHEF QAETKKLLDI VARSLYSEKE VFIRELISNA
       130        140        150        160        170        180
SDALEKLRHK LVSDGQALPE MEIHLQTNAE KGTITIQDTG IGMTQEELVS NLGTIARSGS
       190        200        210        220        230        240
KAFLDALQNQ AEASSKIIGQ FGVGFYSAFM VADRVEVYSR SAAPGSLGYQ WLSDGSGVFE
       250        260        270        280        290        300
IAEASGVRTG TKIIIHLKSD CKEFSSEARV RDVVTKYSNF VSFPLYLNGR RMNTLQAIWM
       310        320        330        340        350        360
MDPKDVREWQ HEEFYRYVAQ AHDKPRYTLH YKTDAPLNIR SIFYVPDMKP SMFDVSRELG
       370        380        390        400        410        420
SSVALYSRKV LIQTKATDIL PKWLRFIRGV VDSEDIPLNL SRELLQESAL IRKLRDVLQQ
       430        440        450        460        470        480
RLIKFFIDQS KKDAEKYAKF FEDYGLFMRE GIVTATEQEV KEDIAKLLRY ESSALPSGQL
       490        500        510        520        530        540
TSLSEYASRM RAGTRNIYYL CAPNRHLAEH SPYYEAMKKK DTEVLFCFEQ FDELTLLHLR
       550        560        570        580        590        600
EFDKKKLISV ETDIVVDHYK EEKFEDRSPA AECLSEKETE ELMAWMRNVL GSRVTNVKVT
       610        620        630        640        650        660
LRLDTHPAMV TVLEMGAARH FLRMQQLAKT QEERAQLLQP TLEINPRHAL IKKLNQLRAS
       670        680        690        700
EPGLAQLLVD QIYENAMIAA GLVDDPRAMV GRLNELLVKA LERH

Isoforms

- Isoform 2 of Heat shock protein 75 kDa, mitochondrial

Sequence View

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Physiological Relevance:

Evidence Codes:

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Protease Assignment Confidence:

Evidence Names:

Database:

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Protein Neighborhood

Domains & Features

6 N-termini - 4 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q12931-60-unknown	STQTAE...	60	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q12931-60-unknown	STQTAE...	60		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q12931-60-unknown	STQTAE...	60	inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
Q12931-60-	STQTAE...	60		Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
Q12931-60-	STQTAE...	60		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q12931-60-	STQTAE...	60		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q12931-60-	STQTAE...	60		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q12931-60-	STQTAE...	60		Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
Q12931-60-	STQTAE...	60		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q12931-60-	STQTAE...	60		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q12931-60-	STQTAE...	60		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q12931-60-	STQTAE...	60		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q12931-60-	STQTAE...	60		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q12931-60-	STQTAE...	60		Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
Q12931-60-	STQTAE...	60		Subtiligase Based Positive Selection		Wells	RMPI_untreated	23264352
Q12931-60-	STQTAE...	60		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q12931-77-unknown	STESVQ...	77	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7755
Q12931-141-unknown	MEIHLQ...	141	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000458244
Q12931-210-unknown	MVADRV...	210	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000458166
Q12931-389-	GVVDSE...	389		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...HSIISS	76	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7755
...NLGTIA	175	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000458244
...QRLIKF	424	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000459354
...ALERH	704	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATS_HUMAN	76	IISS.\|.STES	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)