Q12986: Transcriptional repressor NF-X1

General Information

Protein names	- Transcriptional repressor NF-X1 - 2.3.2.- - Nuclear transcription factor, X box-binding protein 1
Gene names	NFX1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q12986

4 N-termini

4 C-termini

3 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Transcriptional repressor NF-X1 - Isoform 3 of Transcriptional repressor NF-X1

Sequence View

        10         20         30         40         50         60
MAEAPPVSGT FKFNTDAAEF IPQEKKNSGL NCGTQRRLDS NRIGRRNYSS PPPCHLSRQV
        70         80         90        100        110        120
PYDEISAVHQ HSYHPSGSKP KSQQTSFQSS PCNKSPKSHG LQNQPWQKLR NEKHHIRVKK
       130        140        150        160        170        180
AQSLAEQTSD TAGLESSTRS ESGTDLREHS PSESEKEVVG ADPRGAKPKK ATQFVYSYGR
       190        200        210        220        230        240
GPKVKGKLKC EWSNRTTPKP EDAGPESTKP VGVFHPDSSE ASSRKGVLDG YGARRNEQRR
       250        260        270        280        290        300
YPQKRPPWEV EGARPRPGRN PPKQEGHRHT NAGHRNNMGP IPKDDLNERP AKSTCDSENL
       310        320        330        340        350        360
AVINKSSRRV DQEKCTVRRQ DPQVVSPFSR GKQNHVLKNV ETHTGSLIEQ LTTEKYECMV
       370        380        390        400        410        420
CCELVRVTAP VWSCQSCYHV FHLNCIKKWA RSPASQADGQ SGWRCPACQN VSAHVPNTYT
       430        440        450        460        470        480
CFCGKVKNPE WSRNEIPHSC GEVCRKKQPG QDCPHSCNLL CHPGPCPPCP AFMTKTCECG
       490        500        510        520        530        540
RTRHTVRCGQ AVSVHCSNPC ENILNCGQHQ CAELCHGGQC QPCQIILNQV CYCGSTSRDV
       550        560        570        580        590        600
LCGTDVGKSD GFGDFSCLKI CGKDLKCGNH TCSQVCHPQP CQQCPRLPQL VRCCPCGQTP
       610        620        630        640        650        660
LSQLLELGSS SRKTCMDPVP SCGKVCGKPL PCGSLDFIHT CEKLCHEGDC GPCSRTSVIS
       670        680        690        700        710        720
CRCSFRTKEL PCTSLKSEDA TFMCDKRCNK KRLCGRHKCN EICCVDKEHK CPLICGRKLR
       730        740        750        760        770        780
CGLHRCEEPC HRGNCQTCWQ ASFDELTCHC GASVIYPPVP CGTRPPECTQ TCARVHECDH
       790        800        810        820        830        840
PVYHSCHSEE KCPPCTFLTQ KWCMGKHEFR SNIPCHLVDI SCGLPCSATL PCGMHKCQRL
       850        860        870        880        890        900
CHKGECLVDE PCKQPCTTPR ADCGHPCMAP CHTSSPCPVT ACKAKVELQC ECGRRKEMVI
       910        920        930        940        950        960
CSEASSTYQR IAAISMASKI TDMQLGGSVE ISKLITKKEV HQARLECDEE CSALERKKRL
       970        980        990       1000       1010       1020
AEAFHISEDS DPFNIRSSGS KFSDSLKEDA RKDLKFVSDV EKEMETLVEA VNKGKNSKKS
      1030       1040       1050       1060       1070       1080
HSFPPMNRDH RRIIHDLAQV YGLESVSYDS EPKRNVVVTA IRGKSVCPPT TLTGVLEREM
      1090       1100       1110       1120
QARPPPPIPH HRHQSDKNPG SSNLQKITKE PIIDYFDVQD         10         20         30         40         50         60
MAEAPPVSGT FKFNTDAAEF IPQEKKNSGL NCGTQRRLDS NRIGRRNYSS PPPCHLSRQV
        70         80         90        100        110        120
PYDEISAVHQ HSYHPSGSKP KSQQTSFQSS PCNKSPKSHG LQNQPWQKLR NEKHHIRVKK
       130        140        150        160        170        180
AQSLAEQTSD TAGLESSTRS ESGTDLREHS PSESEKEVVG ADPRGAKPKK ATQFVYSYGR
       190        200        210        220        230        240
GPKVKGKLKC EWSNRTTPKP EDAGPESTKP VGVFHPDSSE ASSRKGVLDG YGARRNEQRR
       250        260        270        280        290        300
YPQKRPPWEV EGARPRPGRN PPKQEGHRHT NAGHRNNMGP IPKDDLNERP AKSTCDSENL
       310        320        330        340        350        360
AVINKSSRRV DQEKCTVRRQ DPQVVSPFSR GKQNHVLKNV ETHTGSLIEQ LTTEKYECMV
       370        380        390        400        410        420
CCELVRVTAP VWSCQSCYHV FHLNCIKKWA RSPASQADGQ SGWRCPACQN VSAHVPNTYT
       430        440        450        460        470        480
CFCGKVKNPE WSRNEIPHSC GEVCRKKQPG QDCPHSCNLL CHPGPCPPCP AFMTKTCECG
       490        500        510        520        530        540
RTRHTVRCGQ AVSVHCSNPC ENILNCGQHQ CAELCHGGQC QPCQIILNQV CYCGSTSRDV
       550        560        570        580        590        600
LCGTDVGKSD GFGDFSCLKI CGKDLKCGNH TCSQVCHPQP CQQCPRLPQL VRCCPCGQTP
       610        620        630        640        650        660
LSQLLELGSS SRKTCMDPVP SCGKVCGKPL PCGSLDFIHT CEKLCHEGDC GPCSRTSVIS
       670        680        690        700        710        720
CRCSFRTKEL PCTSLKSEDA TFMCDKRCNK KRLCGRHKCN EICCVDKEHK CPLICGRKLR
       730        740        750        760        770        780
CGLHRCEEPC HRGNCQTCWQ ASFDELTCHC GASVIYPPVP CGTRPPECTQ TCARVHECDH
       790        800        810        820        830        840
PVYHSCHSEE KCPPCTFLTQ KWCMGKHEFR SNIPCHLVDI SCGLPCSATL PCGMHKCQRL
       850        860        870        880        890        900
CHKGECLVDE PCKQPCTTPR ADCGHPCMAP CHTSSPCPVT ACKAKVELQC ECGRRKEMVI
       910        920        930        940        950        960
CSEASSTYQR IAAISMASKI TDMQLGGSVE ISKLITKKEV HQARLECDEE CSALERKKRL
       970        980        990       1000       1010       1020
AEAFHISEDS DPFNIRSSGS KFSDSLKEDA RKDLKFVSDV EKEMETLVEA VNKGKNSKKS
      1030       1040       1050       1060       1070       1080
HSFPPMNRDH RRIIHDLAQV YGLESVSYDS EPKRNVVVTA IRGKSVCPPT TLTGVLEREM
      1090       1100       1110       1120
QARPPPPIPH HRHQSDKNPG SSNLQKITKE PIIDYFDVQD

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q12986-1-unknown	MAEAPP...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q12986-1-unknown	MAEAPP...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt82794
Q12986-1-unknown	MAEAPP...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt82795
Q12986-17-unknown	AAEFIP...	17	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11993
Q12986-17-unknown	AAEFIP...	17	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt136664
Q12986-17-unknown	AAEFIP...	17	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt136665
Q12986-225-unknown	KGVLDG...	225	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10217
Q12986-225-unknown	KGVLDG...	225	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt147566
Q12986-225-unknown	KGVLDG...	225	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt147567
Q12986-296-unknown	DSENLA...	296	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14395
Q12986-296-unknown	DSENLA...	296	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt149763
Q12986-296-unknown	DSENLA...	296	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt149764

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...KFNTDA	16	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11993
...EASSRK	224	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10217
...EASSRK	224	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130918
...EASSRK	224	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130919
...AKSTCD	295	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14395
...AKSTCD	295	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133152
...AKSTCD	295	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133153
...FDVQD	1120	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	16	NTDA.\|.AAEF	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAA_HUMAN	224	SSRK.\|.KGVL	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
GRAM_HUMAN	295	STCD.\|.DSEN	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)