Q13136: Liprin-alpha-1
Protein names | - Liprin-alpha-1 - LAR-interacting protein 1 - LIP-1 - Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1 - PTPRF-interacting protein alpha-1 |
---|---|
Gene names | PPFIA1 |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | Q13136 |
5
N-termini
3
C-termini
2
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MMCEVMPTIS EAEGPPGGGG GHGSGSPSQP DADSHFEQLM VSMLEERDRL LDTLRETQET
70 80 90 100 110 120
LALTQGKLHE VGHERDSLQR QLNTALPQEF AALTKELNVC REQLLEREEE IAELKAERNN
130 140 150 160 170 180
TRLLLEHLEC LVSRHERSLR MTVVKRQAQS PAGVSSEVEV LKALKSLFEH HKALDEKVRE
190 200 210 220 230 240
RLRVALERCS LLEEELGATH KELMILKEQN NQKKTLTDGV LDINHEQENT PSTSGKRSSD
250 260 270 280 290 300
GSLSHEEDLA KVIELQEIIS KQSREQSQMK ERLASLSSHV TELEEDLDTA RKDLIKSEEM
310 320 330 340 350 360
NTKLQRDVRE AMAQKEDMEE RITTLEKRYL AAQREATSVH DLNDKLENEI ANKDSMHRQT
370 380 390 400 410 420
EDKNRQLQER LELAEQKLQQ TLRKAETLPE VEAELAQRVA ALSKAEERHG NIEERLRQME
430 440 450 460 470 480
AQLEEKNQEL QRARQREKMN EEHNKRLSDT VDKLLSESNE RLQLHLKERM AALEDKNSLL
490 500 510 520 530 540
REVESAKKQL EETQHDKDQL VLNIEALRAE LDHMRLRGAS LHHGRPHLGS VPDFRFPMAD
550 560 570 580 590 600
GHTDSYSTSA VLRRPQKGRL AALRDEPSKV QTLNEQDWER AQQASVLANV AQAFESDADV
610 620 630 640 650 660
SDGEDDRDTL LSSVDLLSPS GQADAHTLAM MLQEQLDAIN KEIRLIQEEK ENTEQRAEEI
670 680 690 700 710 720
ESRVGSGSLD NLGRFRSMSS IPPYPASSLA SSSPPGSGRS TPRRIPHSPA REVDRLGVMT
730 740 750 760 770 780
LLPPSREEVR DDKTTIKCET SPPSSPRALR LDRLHKGALH TVSHEDIRDI RNSTGSQDGP
790 800 810 820 830 840
VSNPSSSNSS QDSLHKAPKK KGIKSSIGRL FGKKEKGRPG QTGKEALGQA GVSETDNSSQ
850 860 870 880 890 900
DALGLSKLGG QAEKNRKLQK KHELLEEARR QGLPFAQWDG PTVVVWLELW VGMPAWYVAA
910 920 930 940 950 960
CRANVKSGAI MSALSDTEIQ REIGISNPLH RLKLRLAIQE IMSLTSPSAP PTSRTTLAYG
970 980 990 1000 1010 1020
DMNHEWIGNE WLPSLGLPQY RSYFMECLVD ARMLDHLTKK DLRGQLKMVD SFHRNSFQCG
1030 1040 1050 1060 1070 1080
IMCLRRLNYD RKELERKREE SQSEIKDVLV WSNDRVIRWI LSIGLKEYAN NLIESGVHGA
1090 1100 1110 1120 1130 1140
LLALDETFDF SALALLLQIP TQNTQARAVL EREFNNLLVM GTDRRFDEDD DKSFRRAPSW
1150 1160 1170 1180 1190 1200
RKKFRPKDIR GLAAGSAETL PANFRVTSSM SSPSMQPKKM QMDGNVSGTQ RLDSATVRTY
SC
Isoforms
- Isoform 2 of Liprin-alpha-1Sequence View
10 20 30 40 50 60
MMCEVMPTIS EAEGPPGGGG GHGSGSPSQP DADSHFEQLM VSMLEERDRL LDTLRETQET
70 80 90 100 110 120
LALTQGKLHE VGHERDSLQR QLNTALPQEF AALTKELNVC REQLLEREEE IAELKAERNN
130 140 150 160 170 180
TRLLLEHLEC LVSRHERSLR MTVVKRQAQS PAGVSSEVEV LKALKSLFEH HKALDEKVRE
190 200 210 220 230 240
RLRVALERCS LLEEELGATH KELMILKEQN NQKKTLTDGV LDINHEQENT PSTSGKRSSD
250 260 270 280 290 300
GSLSHEEDLA KVIELQEIIS KQSREQSQMK ERLASLSSHV TELEEDLDTA RKDLIKSEEM
310 320 330 340 350 360
NTKLQRDVRE AMAQKEDMEE RITTLEKRYL AAQREATSVH DLNDKLENEI ANKDSMHRQT
370 380 390 400 410 420
EDKNRQLQER LELAEQKLQQ TLRKAETLPE VEAELAQRVA ALSKAEERHG NIEERLRQME
430 440 450 460 470 480
AQLEEKNQEL QRARQREKMN EEHNKRLSDT VDKLLSESNE RLQLHLKERM AALEDKNSLL
490 500 510 520 530 540
REVESAKKQL EETQHDKDQL VLNIEALRAE LDHMRLRGAS LHHGRPHLGS VPDFRFPMAD
550 560 570 580 590 600
GHTDSYSTSA VLRRPQKGRL AALRDEPSKV QTLNEQDWER AQQASVLANV AQAFESDADV
610 620 630 640 650 660
SDGEDDRDTL LSSVDLLSPS GQADAHTLAM MLQEQLDAIN KEIRLIQEEK ENTEQRAEEI
670 680 690 700 710 720
ESRVGSGSLD NLGRFRSMSS IPPYPASSLA SSSPPGSGRS TPRRIPHSPA REVDRLGVMT
730 740 750 760 770 780
LLPPSREEVR DDKTTIKCET SPPSSPRALR LDRLHKGALH TVSHEDIRDI RNSTGSQDGP
790 800 810 820 830 840
VSNPSSSNSS QDSLHKAPKK KGIKSSIGRL FGKKEKGRPG QTGKEALGQA GVSETDNSSQ
850 860 870 880 890 900
DALGLSKLGG QAEKNRKLQK KHELLEEARR QGLPFAQWDG PTVVVWLELW VGMPAWYVAA
910 920 930 940 950 960
CRANVKSGAI MSALSDTEIQ REIGISNPLH RLKLRLAIQE IMSLTSPSAP PTSRTTLAYG
970 980 990 1000 1010 1020
DMNHEWIGNE WLPSLGLPQY RSYFMECLVD ARMLDHLTKK DLRGQLKMVD SFHRNSFQCG
1030 1040 1050 1060 1070 1080
IMCLRRLNYD RKELERKREE SQSEIKDVLV WSNDRVIRWI LSIGLKEYAN NLIESGVHGA
1090 1100 1110 1120 1130 1140
LLALDETFDF SALALLLQIP TQNTQARAVL EREFNNLLVM GTDRRFDEDD DKSFRRAPSW
1150 1160 1170 1180 1190 1200
RKKFRPKDIR GLAAGSAETL PANFRVTSSM SSPSMQPKKM QMDGNVSGTQ RLDSATVRTY
SC
Protein Neighborhood
Domains & Features
5 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
Q13136-1-unknown | MMCEVM... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
Q13136-1-unknown | MMCEVM... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt79627 | |||
Q13136-34-unknown | SHFEQL... | 34 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC12003 | |||
Q13136-34-unknown | SHFEQL... | 34 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt137920 | |||
Q13136-219- | GVLDIN... | 219 | Subtiligase Based Positive Selection | Wells | DB_Untreated | 23264352 | |||
Q13136-219- | GVLDIN... | 219 | Subtiligase Based Positive Selection | Wells | apoptotic_DB_Doxo | 23264352 | |||
Q13136-219- | GVLDIN... | 219 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_Etoposide | 23264352 | |||
Q13136-219- | GVLDIN... | 219 | Subtiligase Based Positive Selection | Wells | apopotic_Jurkat_FasL | 23264352 | |||
Q13136-219- | GVLDIN... | 219 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
Q13136-219- | GVLDIN... | 219 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
Q13136-219- | GVLDIN... | 219 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 | |||
Q13136-219- | GVLDIN... | 219 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
Q13136-219-unknown | GVLDIN... | 219 | unknown | Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... | 18722006 | ||||
Q13136-219-unknown | GVLDIN... | 219 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt161759 | |||
Q13136-837-unknown | NSSQDA... | 837 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC2159 | |||
Q13136-837-unknown | NSSQDA... | 837 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt156638 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...QPDADS | 33 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC12003 | |||
...QPDADS | 33 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt120928 | |||
...VSETDN | 836 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC2159 | |||
...VSETDN | 836 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt140123 | |||
...RTYSC | 1202 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
GRAB_HUMAN | 33 | DADS.|.SHFE | inferred from experiment | unknown | MEROPS | Gevaert K | Van Damme P et al.:Analysis of protein processing ... (S01.010) | 18836177, |
CASP3_HUMAN | 836 | ETDN.|.NSSQ | inferred from experiment | unknown | MEROPS | Merops CASP3_HUMAN -> LIPA1_HUMAN @836 |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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