Q13492: Phosphatidylinositol-binding clathrin assembly protein
Protein names | - Phosphatidylinositol-binding clathrin assembly protein - Clathrin assembly lymphoid myeloid leukemia protein |
---|---|
Gene names | PICALM |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | Q13492 |
16
N-termini
3
C-termini
2
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MSGQSLTDRI TAAQHSVTGS AVSKTVCKAT THEIMGPKKK HLDYLIQCTN EMNVNIPQLA
70 80 90 100 110 120
DSLFERTTNS SWVVVFKSLI TTHHLMVYGN ERFIQYLASR NTLFNLSNFL DKSGLQGYDM
130 140 150 160 170 180
STFIRRYSRY LNEKAVSYRQ VAFDFTKVKR GADGVMRTMN TEKLLKTVPI IQNQMDALLD
190 200 210 220 230 240
FNVNSNELTN GVINAAFMLL FKDAIRLFAA YNEGIINLLE KYFDMKKNQC KEGLDIYKKF
250 260 270 280 290 300
LTRMTRISEF LKVAEQVGID RGDIPDLSQA PSSLLDALEQ HLASLEGKKI KDSTAASRAT
310 320 330 340 350 360
TLSNAVSSLA STGLSLTKVD EREKQAALEE EQARLKALKE QRLKELAKKP HTSLTTAASP
370 380 390 400 410 420
VSTSAGGIMT APAIDIFSTP SSSNSTSKLP NDLLDLQQPT FHPSVHPMST ASQVASTWGD
430 440 450 460 470 480
PFSATVDAVD DAIPSLNPFL TKSSGDVHLS ISSDVSTFTT RTPTHEMFVG FTPSPVAQPH
490 500 510 520 530 540
PSAGLNVDFE SVFGNKSTNV IVDSGGFDEL GGLLKPTVAS QNQNLPVAKL PPSKLVSDDL
550 560 570 580 590 600
DSSLANLVGN LGIGNGTTKN DVNWSQPGEK KLTGGSNWQP KVAPTTAWNA ATMAPPVMAY
610 620 630 640 650
PATTPTGMIG YGIPPQMGSV PVMTQPTLIY SQPVMRPPNP FGPVSGAQIQ FM
Isoforms
- Isoform 2 of Phosphatidylinositol-binding clathrin assembly protein - Isoform 3 of Phosphatidylinositol-binding clathrin assembly protein - Isoform 4 of Phosphatidylinositol-binding clathrin assembly protein - Isoform 5 of Phosphatidylinositol-binding clathrin assembly proteinSequence View
10 20 30 40 50 60
MSGQSLTDRI TAAQHSVTGS AVSKTVCKAT THEIMGPKKK HLDYLIQCTN EMNVNIPQLA
70 80 90 100 110 120
DSLFERTTNS SWVVVFKSLI TTHHLMVYGN ERFIQYLASR NTLFNLSNFL DKSGLQGYDM
130 140 150 160 170 180
STFIRRYSRY LNEKAVSYRQ VAFDFTKVKR GADGVMRTMN TEKLLKTVPI IQNQMDALLD
190 200 210 220 230 240
FNVNSNELTN GVINAAFMLL FKDAIRLFAA YNEGIINLLE KYFDMKKNQC KEGLDIYKKF
250 260 270 280 290 300
LTRMTRISEF LKVAEQVGID RGDIPDLSQA PSSLLDALEQ HLASLEGKKI KDSTAASRAT
310 320 330 340 350 360
TLSNAVSSLA STGLSLTKVD EREKQAALEE EQARLKALKE QRLKELAKKP HTSLTTAASP
370 380 390 400 410 420
VSTSAGGIMT APAIDIFSTP SSSNSTSKLP NDLLDLQQPT FHPSVHPMST ASQVASTWGD
430 440 450 460 470 480
PFSATVDAVD DAIPSLNPFL TKSSGDVHLS ISSDVSTFTT RTPTHEMFVG FTPSPVAQPH
490 500 510 520 530 540
PSAGLNVDFE SVFGNKSTNV IVDSGGFDEL GGLLKPTVAS QNQNLPVAKL PPSKLVSDDL
550 560 570 580 590 600
DSSLANLVGN LGIGNGTTKN DVNWSQPGEK KLTGGSNWQP KVAPTTAWNA ATMAPPVMAY
610 620 630 640 650
PATTPTGMIG YGIPPQMGSV PVMTQPTLIY SQPVMRPPNP FGPVSGAQIQ FM
10 20 30 40 50 60
MSGQSLTDRI TAAQHSVTGS AVSKTVCKAT THEIMGPKKK HLDYLIQCTN EMNVNIPQLA
70 80 90 100 110 120
DSLFERTTNS SWVVVFKSLI TTHHLMVYGN ERFIQYLASR NTLFNLSNFL DKSGLQGYDM
130 140 150 160 170 180
STFIRRYSRY LNEKAVSYRQ VAFDFTKVKR GADGVMRTMN TEKLLKTVPI IQNQMDALLD
190 200 210 220 230 240
FNVNSNELTN GVINAAFMLL FKDAIRLFAA YNEGIINLLE KYFDMKKNQC KEGLDIYKKF
250 260 270 280 290 300
LTRMTRISEF LKVAEQVGID RGDIPDLSQA PSSLLDALEQ HLASLEGKKI KDSTAASRAT
310 320 330 340 350 360
TLSNAVSSLA STGLSLTKVD EREKQAALEE EQARLKALKE QRLKELAKKP HTSLTTAASP
370 380 390 400 410 420
VSTSAGGIMT APAIDIFSTP SSSNSTSKLP NDLLDLQQPT FHPSVHPMST ASQVASTWGD
430 440 450 460 470 480
PFSATVDAVD DAIPSLNPFL TKSSGDVHLS ISSDVSTFTT RTPTHEMFVG FTPSPVAQPH
490 500 510 520 530 540
PSAGLNVDFE SVFGNKSTNV IVDSGGFDEL GGLLKPTVAS QNQNLPVAKL PPSKLVSDDL
550 560 570 580 590 600
DSSLANLVGN LGIGNGTTKN DVNWSQPGEK KLTGGSNWQP KVAPTTAWNA ATMAPPVMAY
610 620 630 640 650
PATTPTGMIG YGIPPQMGSV PVMTQPTLIY SQPVMRPPNP FGPVSGAQIQ FM
10 20 30 40 50 60
MSGQSLTDRI TAAQHSVTGS AVSKTVCKAT THEIMGPKKK HLDYLIQCTN EMNVNIPQLA
70 80 90 100 110 120
DSLFERTTNS SWVVVFKSLI TTHHLMVYGN ERFIQYLASR NTLFNLSNFL DKSGLQGYDM
130 140 150 160 170 180
STFIRRYSRY LNEKAVSYRQ VAFDFTKVKR GADGVMRTMN TEKLLKTVPI IQNQMDALLD
190 200 210 220 230 240
FNVNSNELTN GVINAAFMLL FKDAIRLFAA YNEGIINLLE KYFDMKKNQC KEGLDIYKKF
250 260 270 280 290 300
LTRMTRISEF LKVAEQVGID RGDIPDLSQA PSSLLDALEQ HLASLEGKKI KDSTAASRAT
310 320 330 340 350 360
TLSNAVSSLA STGLSLTKVD EREKQAALEE EQARLKALKE QRLKELAKKP HTSLTTAASP
370 380 390 400 410 420
VSTSAGGIMT APAIDIFSTP SSSNSTSKLP NDLLDLQQPT FHPSVHPMST ASQVASTWGD
430 440 450 460 470 480
PFSATVDAVD DAIPSLNPFL TKSSGDVHLS ISSDVSTFTT RTPTHEMFVG FTPSPVAQPH
490 500 510 520 530 540
PSAGLNVDFE SVFGNKSTNV IVDSGGFDEL GGLLKPTVAS QNQNLPVAKL PPSKLVSDDL
550 560 570 580 590 600
DSSLANLVGN LGIGNGTTKN DVNWSQPGEK KLTGGSNWQP KVAPTTAWNA ATMAPPVMAY
610 620 630 640 650
PATTPTGMIG YGIPPQMGSV PVMTQPTLIY SQPVMRPPNP FGPVSGAQIQ FM
10 20 30 40 50 60
MSGQSLTDRI TAAQHSVTGS AVSKTVCKAT THEIMGPKKK HLDYLIQCTN EMNVNIPQLA
70 80 90 100 110 120
DSLFERTTNS SWVVVFKSLI TTHHLMVYGN ERFIQYLASR NTLFNLSNFL DKSGLQGYDM
130 140 150 160 170 180
STFIRRYSRY LNEKAVSYRQ VAFDFTKVKR GADGVMRTMN TEKLLKTVPI IQNQMDALLD
190 200 210 220 230 240
FNVNSNELTN GVINAAFMLL FKDAIRLFAA YNEGIINLLE KYFDMKKNQC KEGLDIYKKF
250 260 270 280 290 300
LTRMTRISEF LKVAEQVGID RGDIPDLSQA PSSLLDALEQ HLASLEGKKI KDSTAASRAT
310 320 330 340 350 360
TLSNAVSSLA STGLSLTKVD EREKQAALEE EQARLKALKE QRLKELAKKP HTSLTTAASP
370 380 390 400 410 420
VSTSAGGIMT APAIDIFSTP SSSNSTSKLP NDLLDLQQPT FHPSVHPMST ASQVASTWGD
430 440 450 460 470 480
PFSATVDAVD DAIPSLNPFL TKSSGDVHLS ISSDVSTFTT RTPTHEMFVG FTPSPVAQPH
490 500 510 520 530 540
PSAGLNVDFE SVFGNKSTNV IVDSGGFDEL GGLLKPTVAS QNQNLPVAKL PPSKLVSDDL
550 560 570 580 590 600
DSSLANLVGN LGIGNGTTKN DVNWSQPGEK KLTGGSNWQP KVAPTTAWNA ATMAPPVMAY
610 620 630 640 650
PATTPTGMIG YGIPPQMGSV PVMTQPTLIY SQPVMRPPNP FGPVSGAQIQ FM
Protein Neighborhood
Domains & Features
16 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
Q13492-1-unknown | MSGQSL... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt85164 | |||
Q13492-1-unknown | MSGQSL... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt85165 | |||
Q13492-1-unknown | MSGQSL... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt85167 | |||
Q13492-2-unknown | MSGQSL... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
Q13492-2-Acetylation | SGQSLT... | 2 | acetylation- | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | ||
Q13492-2-Acetylation | SGQSLT... | 2 | acetylation- | COFRADIC | Gevaert K. | Van Damme P et al.: Complementary positional proteomics for screening substrates... | 20526345 | ||
Q13492-2-Acetylation | SGQSLT... | 2 | acetylation- | COFRADIC | Gevaert K. | Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates... | 20526345 | ||
Q13492-2-Acetylation | SGQSLT... | 2 | acetylation- | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt110904 | ||
Q13492-2-Acetylation | SGQSLT... | 2 | acetylation- | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt110905 | ||
Q13492-2-Acetylation | SGQSLT... | 2 | acetylation- | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt110906 | ||
Q13492-52-unknown | MNVNIP... | 52 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt85166 | |||
Q13492-52-unknown | MNVNIP... | 52 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt105615 | |||
Q13492-52-unknown | MNVNIP... | 52 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt105616 | |||
Q13492-52-unknown | MNVNIP... | 52 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt105617 | |||
Q13492-277- | ALEQHL... | 277 | Subtiligase Based Positive Selection | Wells | apoptotic_DB_Doxo | 23264352 | |||
Q13492-277-unknown | ALEQHL... | 277 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt165966 | |||
Q13492-277-unknown | ALEQHL... | 277 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt165965 | |||
Q13492-277-unknown | ALEQHL... | 277 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt165967 | |||
Q13492-277-unknown | ALEQHL... | 277 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt165968 | |||
Q13492-310-unknown | ASTGLS... | 310 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC14437 | |||
Q13492-310-unknown | ASTGLS... | 310 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt148775 | |||
Q13492-310-unknown | ASTGLS... | 310 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt150117 | |||
Q13492-310-unknown | ASTGLS... | 310 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt150118 | |||
Q13492-310-unknown | ASTGLS... | 310 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt150119 | |||
Q13492-373-unknown | AIDIFS... | 373 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt164690 | |||
Q13492-373-unknown | AIDIFS... | 373 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt164689 | |||
Q13492-373-unknown | AIDIFS... | 373 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt164691 | |||
Q13492-373-unknown | AIDIFS... | 373 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt164692 | |||
Q13492-373- | AIDIFS... | 373 | Subtiligase Based Positive Selection | Wells | DB_Untreated | 23264352 | |||
Q13492-428-unknown | AVDDAI... | 428 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt176512 | |||
Q13492-428-unknown | AVDDAI... | 428 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt176513 | |||
Q13492-428- | AVDDAI... | 428 | Subtiligase Based Positive Selection | Wells | MM1SDBJurkat_Untreated | 23264352 | |||
Q13492-450- | SISSDV... | 450 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
Q13492-450- | SISSDV... | 450 | Subtiligase Based Positive Selection | Wells | MM1SDBJurkat_Untreated | 23264352 | |||
Q13492-450-unknown | SISSDV... | 450 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt174378 | |||
Q13492-450-unknown | SISSDV... | 450 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt174379 | |||
Q13492-486-unknown | NVDFES... | 486 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt176508 | |||
Q13492-486-unknown | NVDFES... | 486 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt176509 | |||
Q13492-486-unknown | NVDFES... | 486 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt176507 | |||
Q13492-486-unknown | NVDFES... | 486 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt176510 | |||
Q13492-486- | NVDFES... | 486 | Subtiligase Based Positive Selection | Wells | MM1SDBJurkat_Untreated | 23264352 | |||
Q13492-520-unknown | SQNQNL... | 520 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC7779 | |||
Q13492-520-unknown | SQNQNL... | 520 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt152318 | |||
Q13492-520-unknown | SQNQNL... | 520 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt153082 | |||
Q13492-520-unknown | SQNQNL... | 520 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt153566 | |||
Q13492-520-unknown | SQNQNL... | 520 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt153624 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...AVSSLA | 309 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC14437 | |||
...AVSSLA | 309 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt132151 | |||
...AVSSLA | 309 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt133509 | |||
...AVSSLA | 309 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt133510 | |||
...AVSSLA | 309 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt133511 | |||
...KPTVAS | 519 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC7779 | |||
...KPTVAS | 519 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt135729 | |||
...KPTVAS | 519 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt136507 | |||
...KPTVAS | 519 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt136988 | |||
...KPTVAS | 519 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt137047 | |||
...QIQFM | 652 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...QIQFM | 652 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt80784 | |||
...QIQFM | 652 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt80783 | |||
...QIQFM | 652 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt80782 | |||
...QIQFM | 652 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt80785 |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
GRAM_HUMAN | 309 | SSLA.|.ASTG | inferred from experiment | unknown | MEROPS | Bovenschen N | de Poot SA et al.:Human and mouse granzyme M disp... (S01.139) | 21564021, |
CATS_HUMAN | 519 | TVAS.|.SQNQ | inferred from experiment | unknown | MEROPS | Schilling O | Biniossek ML et al.:Proteomic identification of pro... (C01.060) | 21967108, |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|