Q13509: Tubulin beta-3 chain

General Information

Protein names	- Tubulin beta-3 chain - Tubulin beta-4 chain - Tubulin beta-III
Gene names	TUBB3
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q13509

14 N-termini

13 C-termini

12 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MREIVHIQAG QCGNQIGAKF WEVISDEHGI DPSGNYVGDS DLQLERISVY YNEASSHKYV
        70         80         90        100        110        120
PRAILVDLEP GTMDSVRSGA FGHLFRPDNF IFGQSGAGNN WAKGHYTEGA ELVDSVLDVV
       130        140        150        160        170        180
RKECENCDCL QGFQLTHSLG GGTGSGMGTL LISKVREEYP DRIMNTFSVV PSPKVSDTVV
       190        200        210        220        230        240
EPYNATLSIH QLVENTDETY CIDNEALYDI CFRTLKLATP TYGDLNHLVS ATMSGVTTSL
       250        260        270        280        290        300
RFPGQLNADL RKLAVNMVPF PRLHFFMPGF APLTARGSQQ YRALTVPELT QQMFDAKNMM
       310        320        330        340        350        360
AACDPRHGRY LTVATVFRGR MSMKEVDEQM LAIQSKNSSY FVEWIPNNVK VAVCDIPPRG
       370        380        390        400        410        420
LKMSSTFIGN STAIQELFKR ISEQFTAMFR RKAFLHWYTG EGMDEMEFTE AESNMNDLVS
       430        440        450
EYQQYQDATA EEEGEMYEDD EEESEAQGPK

Isoforms

- Isoform 2 of Tubulin beta-3 chain

Sequence View

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Protein Neighborhood

Domains & Features

14 N-termini - 13 C-termini - 12 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q13509-1-unknown	MREIVH...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q13509-63-unknown	AILVDL...	63	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10264
Q13509-63-unknown	AILVDL...	63	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13678
Q13509-67-unknown	DLEPGT...	67	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15399
Q13509-73-unknown	MDSVRS...	73	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt91590
Q13509-73-unknown	MDSVRS...	73	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000450538
Q13509-73-unknown	MDSVRS...	73	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000451617
Q13509-73-unknown	MDSVRS...	73	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000452166
Q13509-73-unknown	MDSVRS...	73	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000302777
Q13509-80-	AFGHLF...	80		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q13509-80-unknown	AFGHLF...	80	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt174958
Q13509-102-unknown	AKGHYT...	102	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15400
Q13509-102-unknown	AKGHYT...	102	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12084
Q13509-102-unknown	AKGHYT...	102	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt137515
Q13509-108-unknown	EGAELV...	108	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15402
Q13509-108-unknown	EGAELV...	108	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt138006
Q13509-115-unknown	SVLDVV...	115	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12086
Q13509-115-unknown	SVLDVV...	115	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt138579
Q13509-206-unknown	ALYDIC...	206	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12088
Q13509-206-unknown	ALYDIC...	206	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt144034
Q13509-241-unknown	RFPGQL...	241	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15404
Q13509-241-unknown	RFPGQL...	241	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145483
Q13509-252-unknown	KLAVNM...	252	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10265
Q13509-252-unknown	KLAVNM...	252	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145881
Q13509-254-unknown	AVNMVP...	254	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15406
Q13509-254-unknown	AVNMVP...	254	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145957
Q13509-283-unknown	ALTVPE...	283	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13679
Q13509-283-unknown	ALTVPE...	283	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt147010

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...KYVPRA	62	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10264
...KYVPRA	62	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13678
...RAILVD	66	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15399
...AGNNWA	101	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15400
...AGNNWA	101	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12084
...AGNNWA	101	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120493
...KGHYTE	107	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15402
...KGHYTE	107	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt121018
...AELVDS	114	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12086
...AELVDS	114	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt121629
...DSVLDV	118	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000452166
...DSVLDV	118	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt114762
...CIDNEA	205	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12088
...CIDNEA	205	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127280
...VTTSLR	240	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15404
...VTTSLR	240	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128779
...NADLRK	251	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10265
...NADLRK	251	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129179
...DLRKLA	253	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15406
...DLRKLA	253	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129256
...MVPFPR	261	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000450538
...MVPFPR	261	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt114760
...SQQYRA	282	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13679
...SQQYRA	282	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130343
...AQGPK	450	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...AQGPK	450	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt87208

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAA_HUMAN	62	VPRA.\|.AILV	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
GRAK_HUMAN	62	VPRA.\|.AILV	inferred from experiment	unknown	MEROPS	Kummer JA	Bovenschen N et al.:Granzyme K displays highly rest... (S01.146)	19059912,
HTRA2_HUMAN	66	ILVD.\|.DLEP	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,
HTRA2_HUMAN	101	NNWA.\|.AKGH	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,
GRAB_HUMAN	101	NNWA.\|.AKGH	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
HTRA2_HUMAN	107	HYTE.\|.EGAE	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,
GRAB_HUMAN	114	LVDS.\|.SVLD	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
GRAB_HUMAN	205	DNEA.\|.ALYD	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
HTRA2_HUMAN	240	TSLR.\|.RFPG	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,
GRAA_HUMAN	251	DLRK.\|.KLAV	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
HTRA2_HUMAN	253	RKLA.\|.AVNM	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,
GRAK_HUMAN	282	QYRA.\|.ALTV	inferred from experiment	unknown	MEROPS	Kummer JA	Bovenschen N et al.:Granzyme K displays highly rest... (S01.146)	19059912,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)