Q14160: Protein scribble homolog

General Information

Protein names	- Protein scribble homolog - Scribble - hScrib - Protein LAP4
Gene names	SCRIB
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q14160

21 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Protein scribble homolog - Isoform 3 of Protein scribble homolog

Sequence View

        10         20         30         40         50         60
MLKCIPLWRC NRHVESVDKR HCSLQAVPEE IYRYSRSLEE LLLDANQLRE LPKPFFRLLN
        70         80         90        100        110        120
LRKLGLSDNE IQRLPPEVAN FMQLVELDVS RNDIPEIPES IKFCKALEIA DFSGNPLSRL
       130        140        150        160        170        180
PDGFTQLRSL AHLALNDVSL QALPGDVGNL ANLVTLELRE NLLKSLPASL SFLVKLEQLD
       190        200        210        220        230        240
LGGNDLEVLP DTLGALPNLR ELWLDRNQLS ALPPELGNLR RLVCLDVSEN RLEELPAELG
       250        260        270        280        290        300
GLVLLTDLLL SQNLLRRLPD GIGQLKQLSI LKVDQNRLCE VTEAIGDCEN LSELILTENL
       310        320        330        340        350        360
LMALPRSLGK LTKLTNLNVD RNHLEALPPE IGGCVALSVL SLRDNRLAVL PPELAHTTEL
       370        380        390        400        410        420
HVLDVAGNRL QSLPFALTHL NLKALWLAEN QAQPMLRFQT EDDARTGEKV LTCYLLPQQP
       430        440        450        460        470        480
PPSLEDAGQQ GSLSETWSDA PPSRVSVIQF LEAPIGDEDA EEAAAEKRGL QRRATPHPSE
       490        500        510        520        530        540
LKVMKRSIEG RRSEACPCQP DSGSPLPAEE EKRLSAESGL SEDSRPSAST VSEAEPEGPS
       550        560        570        580        590        600
AEAQGGSQQE ATTAGGEEDA EEDYQEPTVH FAEDALLPGD DREIEEGQPE APWTLPGGRQ
       610        620        630        640        650        660
RLIRKDTPHY KKHFKISKLP QPEAVVALLQ GMQPDGEGPV APGGWHNGPH APWAPRAQKE
       670        680        690        700        710        720
EEEEEEGSPQ EEEVEEEEEN RAEEEEASTE EEDKEGAVVS APSVKGVSFD QANNLLIEPA
       730        740        750        760        770        780
RIEEEELTLT ILRQTGGLGI SIAGGKGSTP YKGDDEGIFI SRVSEEGPAA RAGVRVGDKL
       790        800        810        820        830        840
LEVNGVALQG AEHHEAVEAL RGAGTAVQMR VWRERMVEPE NAVTITPLRP EDDYSPRERR
       850        860        870        880        890        900
GGGLRLPLLP PESPGPLRQR HVACLARSER GLGFSIAGGK GSTPYRAGDA GIFVSRIAEG
       910        920        930        940        950        960
GAAHRAGTLQ VGDRVLSING VDVTEARHDH AVSLLTAASP TIALLLEREA GGPLPPSPLP
       970        980        990       1000       1010       1020
HSSPPTAAVA TTSITTATPG VPGLPSLAPS LLAAALEGPY PVEEIRLPRA GGPLGLSIVG
      1030       1040       1050       1060       1070       1080
GSDHSSHPFG VQEPGVFISK VLPRGLAARS GLRVGDRILA VNGQDVRDAT HQEAVSALLR
      1090       1100       1110       1120       1130       1140
PCLELSLLVR RDPAPPGLRE LCIQKAPGER LGISIRGGAR GHAGNPRDPT DEGIFISKVS
      1150       1160       1170       1180       1190       1200
PTGAAGRDGR LRVGLRLLEV NQQSLLGLTH GEAVQLLRSV GDTLTVLVCD GFEASTDAAL
      1210       1220       1230       1240       1250       1260
EVSPGVIANP FAAGIGHRNS LESISSIDRE LSPEGPGKEK ELPGQTLHWG PEATEAAGRG
      1270       1280       1290       1300       1310       1320
LQPLKLDYRA LAAVPSAGSV QRVPSGAAGG KMAESPCSPS GQQPPSPPSP DELPANVKQA
      1330       1340       1350       1360       1370       1380
YRAFAAVPTS HPPEDAPAQP PTPGPAASPE QLSFRERQKY FELEVRVPQA EGPPKRVSLV
      1390       1400       1410       1420       1430       1440
GADDLRKMQE EEARKLQQKR AQMLREAAEA GAEARLALDG ETLGEEEQED EQPPWASPSP
      1450       1460       1470       1480       1490       1500
TSRQSPASPP PLGGGAPVRT AKAERRHQER LRVQSPEPPA PERALSPAEL RALEAEKRAL
      1510       1520       1530       1540       1550       1560
WRAARMKSLE QDALRAQMVL SRSQEGRGTR GPLERLAEAP SPAPTPSPTP VEDLGPQTST
      1570       1580       1590       1600       1610       1620
SPGRLSPDFA EELRSLEPSP SPGPQEEDGE VALVLLGRPS PGAVGPEDVA LCSSRRPVRP
      1630
GRRGLGPVPS         10         20         30         40         50         60
MLKCIPLWRC NRHVESVDKR HCSLQAVPEE IYRYSRSLEE LLLDANQLRE LPKPFFRLLN
        70         80         90        100        110        120
LRKLGLSDNE IQRLPPEVAN FMQLVELDVS RNDIPEIPES IKFCKALEIA DFSGNPLSRL
       130        140        150        160        170        180
PDGFTQLRSL AHLALNDVSL QALPGDVGNL ANLVTLELRE NLLKSLPASL SFLVKLEQLD
       190        200        210        220        230        240
LGGNDLEVLP DTLGALPNLR ELWLDRNQLS ALPPELGNLR RLVCLDVSEN RLEELPAELG
       250        260        270        280        290        300
GLVLLTDLLL SQNLLRRLPD GIGQLKQLSI LKVDQNRLCE VTEAIGDCEN LSELILTENL
       310        320        330        340        350        360
LMALPRSLGK LTKLTNLNVD RNHLEALPPE IGGCVALSVL SLRDNRLAVL PPELAHTTEL
       370        380        390        400        410        420
HVLDVAGNRL QSLPFALTHL NLKALWLAEN QAQPMLRFQT EDDARTGEKV LTCYLLPQQP
       430        440        450        460        470        480
PPSLEDAGQQ GSLSETWSDA PPSRVSVIQF LEAPIGDEDA EEAAAEKRGL QRRATPHPSE
       490        500        510        520        530        540
LKVMKRSIEG RRSEACPCQP DSGSPLPAEE EKRLSAESGL SEDSRPSAST VSEAEPEGPS
       550        560        570        580        590        600
AEAQGGSQQE ATTAGGEEDA EEDYQEPTVH FAEDALLPGD DREIEEGQPE APWTLPGGRQ
       610        620        630        640        650        660
RLIRKDTPHY KKHFKISKLP QPEAVVALLQ GMQPDGEGPV APGGWHNGPH APWAPRAQKE
       670        680        690        700        710        720
EEEEEEGSPQ EEEVEEEEEN RAEEEEASTE EEDKEGAVVS APSVKGVSFD QANNLLIEPA
       730        740        750        760        770        780
RIEEEELTLT ILRQTGGLGI SIAGGKGSTP YKGDDEGIFI SRVSEEGPAA RAGVRVGDKL
       790        800        810        820        830        840
LEVNGVALQG AEHHEAVEAL RGAGTAVQMR VWRERMVEPE NAVTITPLRP EDDYSPRERR
       850        860        870        880        890        900
GGGLRLPLLP PESPGPLRQR HVACLARSER GLGFSIAGGK GSTPYRAGDA GIFVSRIAEG
       910        920        930        940        950        960
GAAHRAGTLQ VGDRVLSING VDVTEARHDH AVSLLTAASP TIALLLEREA GGPLPPSPLP
       970        980        990       1000       1010       1020
HSSPPTAAVA TTSITTATPG VPGLPSLAPS LLAAALEGPY PVEEIRLPRA GGPLGLSIVG
      1030       1040       1050       1060       1070       1080
GSDHSSHPFG VQEPGVFISK VLPRGLAARS GLRVGDRILA VNGQDVRDAT HQEAVSALLR
      1090       1100       1110       1120       1130       1140
PCLELSLLVR RDPAPPGLRE LCIQKAPGER LGISIRGGAR GHAGNPRDPT DEGIFISKVS
      1150       1160       1170       1180       1190       1200
PTGAAGRDGR LRVGLRLLEV NQQSLLGLTH GEAVQLLRSV GDTLTVLVCD GFEASTDAAL
      1210       1220       1230       1240       1250       1260
EVSPGVIANP FAAGIGHRNS LESISSIDRE LSPEGPGKEK ELPGQTLHWG PEATEAAGRG
      1270       1280       1290       1300       1310       1320
LQPLKLDYRA LAAVPSAGSV QRVPSGAAGG KMAESPCSPS GQQPPSPPSP DELPANVKQA
      1330       1340       1350       1360       1370       1380
YRAFAAVPTS HPPEDAPAQP PTPGPAASPE QLSFRERQKY FELEVRVPQA EGPPKRVSLV
      1390       1400       1410       1420       1430       1440
GADDLRKMQE EEARKLQQKR AQMLREAAEA GAEARLALDG ETLGEEEQED EQPPWASPSP
      1450       1460       1470       1480       1490       1500
TSRQSPASPP PLGGGAPVRT AKAERRHQER LRVQSPEPPA PERALSPAEL RALEAEKRAL
      1510       1520       1530       1540       1550       1560
WRAARMKSLE QDALRAQMVL SRSQEGRGTR GPLERLAEAP SPAPTPSPTP VEDLGPQTST
      1570       1580       1590       1600       1610       1620
SPGRLSPDFA EELRSLEPSP SPGPQEEDGE VALVLLGRPS PGAVGPEDVA LCSSRRPVRP
      1630
GRRGLGPVPS

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

21 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q14160-1-unknown	MLKCIP...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q14160-1-unknown	MLKCIP...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt89115
Q14160-82-unknown	MQLVEL...	82	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt89114
Q14160-82-unknown	MQLVEL...	82	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt97381
Q14160-502-unknown	SGSPLP...	502	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt174716
Q14160-502-unknown	SGSPLP...	502	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt174715
Q14160-502-	SGSPLP...	502		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q14160-503-unknown	GSPLPA...	503	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173334
Q14160-503-unknown	GSPLPA...	503	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173333
Q14160-503-	GSPLPA...	503		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q14160-636-	GEGPVA...	636		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q14160-636-	GEGPVA...	636		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q14160-636-unknown	GEGPVA...	636	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165502
Q14160-636-unknown	GEGPVA...	636	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165501
Q14160-1198-unknown	AALEVS...	1198	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165505
Q14160-1198-unknown	AALEVS...	1198	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165504
Q14160-1198-	AALEVS...	1198		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q14160-1198-	AALEVS...	1198		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q14160-1198-	AALEVS...	1198		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q14160-1198-	AALEVS...	1198		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q14160-1199-	ALEVSP...	1199		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q14160-1199-unknown	ALEVSP...	1199	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt174707
Q14160-1199-unknown	ALEVSP...	1199	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt174706
Q14160-1205-	GVIANP...	1205		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q14160-1205-	GVIANP...	1205		Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
Q14160-1205-unknown	GVIANP...	1205	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt174710
Q14160-1205-unknown	GVIANP...	1205	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt174709
Q14160-1270-unknown	ALAAVP...	1270	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10285
Q14160-1270-unknown	ALAAVP...	1270	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt157659
Q14160-1270-unknown	ALAAVP...	1270	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt157858
Q14160-1273-	AVPSAG...	1273		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q14160-1273-	AVPSAG...	1273		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q14160-1273-	AVPSAG...	1273		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q14160-1273-unknown	AVPSAG...	1273	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167803
Q14160-1273-unknown	AVPSAG...	1273	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167802
Q14160-1325-	AAVPTS...	1325		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q14160-1325-unknown	AAVPTS...	1325	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt174713
Q14160-1325-unknown	AAVPTS...	1325	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt174712
Q14160-1420-	GETLGE...	1420		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q14160-1420-	GETLGE...	1420		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q14160-1420-	GETLGE...	1420		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q14160-1420-unknown	GETLGE...	1420	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173331
Q14160-1420-unknown	GETLGE...	1420	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173330
Q14160-1420-unknown	GETLGE...	1420	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...KLDYRA	1269	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10285
...KLDYRA	1269	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt141158
...KLDYRA	1269	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt141355
...GPVPS	1630	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...GPVPS	1630	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt84732
...GPVPS	1630	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt84733

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAA_HUMAN	1269	DYRA.\|.ALAA	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)