Q14241: Elongin-A

General Information

Protein names	- Elongin-A - EloA - Elongin 110 kDa subunit - RNA polymerase II transcription factor SIII subunit A1 - SIII p110 - Transcription elongation factor B polypeptide 3
Gene names	TCEB3
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q14241

10 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MHGGRSCGPR TRREPSSGEE AAPVTAMAAE SALQVVEKLQ ARLAANPDPK KLLKYLKKLS
        70         80         90        100        110        120
TLPITVDILA ETGVGKTVNS LRKHEHVGSF ARDLVAQWKK LVPVERNAEP DEQDFEKSNS
       130        140        150        160        170        180
RKRPRDALQK EEEMEGDYQE TWKATGSRSY SPDHRQKKHR KLSELERPHK VSHGHERRDE
       190        200        210        220        230        240
RKRCHRMSPT YSSDPESSDY GHVQSPPSCT SPHQMYVDHY RSLEEDQEPI VSHQKPGKGH
       250        260        270        280        290        300
SNAFQDRLGA SQERHLGEPH GKGVVSQNKE HKSSHKDKRP VDAKSDEKAS VVSREKSHKA
       310        320        330        340        350        360
LSKEENRRPP SGDNAREKPP SSGVKKEKDR EGSSLKKKCL PPSEAASDNH LKKPKHRDPE
       370        380        390        400        410        420
KAKLDKSKQG LDSFDTGKGA GDLLPKVKEK GSNNLKTPEG KVKTNLDRKS LGSLPKVEET
       430        440        450        460        470        480
DMEDEFEQPT MSFESYLSYD QPRKKKKKIV KTSATALGDK GLKKNDSKST GKNLDSVQKL
       490        500        510        520        530        540
PKVNKTKSEK PAGADLAKLR KVPDVLPVLP DLPLPAIQAN YRPLPSLELI SSFQPKRKAF
       550        560        570        580        590        600
SSPQEEEEAG FTGRRMNSKM QVYSGSKCAY LPKMMTLHQQ CIRVLKNNID SIFEVGGVPY
       610        620        630        640        650        660
SVLEPVLERC TPDQLYRIEE YNHVLIEETD QLWKVHCHRD FKEERPEEYE SWREMYLRLQ
       670        680        690        700        710        720
DAREQRLRVL TKNIQFAHAN KPKGRQAKMA FVNSVAKPPR DVRRRQEKFG TGGAAVPEKI
       730        740        750        760        770        780
KIKPAPYPMG SSHASASSIS FNPSPEEPAY DGPSTSSAHL APVVSSTVSY DPRKPTVKKI
       790
APMMAKTIKA FKNRFSRR

Isoforms

Sequence View

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Evidence Names:

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Protein Neighborhood

Domains & Features

10 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q14241-1-unknown	MHGGRS...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q14241-2-acetylation	HGGRSC...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q14241-2-acetylation	HGGRSC...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
Q14241-2-acetylation	HGGRSC...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q14241-27-unknown	MAAESA...	27		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000476781
Q14241-28-	AAESAL...	28			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q14241-28-	AAESAL...	28			Subtiligase Based Positive Selection		Wells	THP_untreated	23264352
Q14241-138-unknown	YQETWK...	138		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12224
Q14241-222-	SLEEDQ...	222			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q14241-222-	SLEEDQ...	222			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
Q14241-435-unknown	SYLSYD...	435		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12225
Q14241-539-	AFSSPQ...	539			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q14241-539-	AFSSPQ...	539			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q14241-690-	AFVNSV...	690			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q14241-692-	VNSVAK...	692			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...EMEGDY	137	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12224
...TMSFES	434	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12225
...RFSRR	798	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	137	EGDY.\|.YQET	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAB_HUMAN	434	SFES.\|.SYLS	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)