Q14671: Pumilio homolog 1 {ECO:0000305}
Protein names | - Pumilio homolog 1 {ECO:0000305} - HsPUM - Pumilio-1 |
---|---|
Gene names | PUM1 |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | Q14671 |
13
N-termini
2
C-termini
1
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MSVACVLKRK AVLWQDSFSP HLKHHPQEPA NPNMPVVLTS GTGSQAQPQP AANQALAAGT
70 80 90 100 110 120
HSSPVPGSIG VAGRSQDDAM VDYFFQRQHG EQLGGGGSGG GGYNNSKHRW PTGDNIHAEH
130 140 150 160 170 180
QVRSMDELNH DFQALALEGR AMGEQLLPGK KFWETDESSK DGPKGIFLGD QWRDSAWGTS
190 200 210 220 230 240
DHSVSQPIMV QRRPGQSFHV NSEVNSVLSP RSESGGLGVS MVEYVLSSSP GDSCLRKGGF
250 260 270 280 290 300
GPRDADSDEN DKGEKKNKGT FDGDKLGDLK EEGDVMDKTN GLPVQNGIDA DVKDFSRTPG
310 320 330 340 350 360
NCQNSANEVD LLGPNQNGSE GLAQLTSTNG AKPVEDFSNM ESQSVPLDPM EHVGMEPLQF
370 380 390 400 410 420
DYSGTQVPVD SAAATVGLFD YNSQQQLFQR PNALAVQQLT AAQQQQYALA AAHQPHIGLA
430 440 450 460 470 480
PAAFVPNPYI ISAAPPGTDP YTAGLAAAAT LGPAVVPHQY YGVTPWGVYP ASLFQQQAAA
490 500 510 520 530 540
AAAATNSANQ QTTPQAQQGQ QQVLRGGASQ RPLTPNQNQQ GQQTDPLVAA AAVNSALAFG
550 560 570 580 590 600
QGLAAGMPGY PVLAPAAYYD QTGALVVNAG ARNGLGAPVR LVAPAPVIIS SSAAQAAVAA
610 620 630 640 650 660
AAASANGAAG GLAGTTNGPF RPLGTQQPQP QPQQQPNNNL ASSSFYGNNS LNSNSQSSSL
670 680 690 700 710 720
FSQGSAQPAN TSLGFGSSSS LGATLGSALG GFGTAVANSN TGSGSRRDSL TGSSDLYKRT
730 740 750 760 770 780
SSSLTPIGHS FYNGLSFSSS PGPVGMPLPS QGPGHSQTPP PSLSSHGSSS SLNLGGLTNG
790 800 810 820 830 840
SGRYISAAPG AEAKYRSASS ASSLFSPSST LFSSSRLRYG MSDVMPSGRS RLLEDFRNNR
850 860 870 880 890 900
YPNLQLREIA GHIMEFSQDQ HGSRFIQLKL ERATPAERQL VFNEILQAAY QLMVDVFGNY
910 920 930 940 950 960
VIQKFFEFGS LEQKLALAER IRGHVLSLAL QMYGCRVIQK ALEFIPSDQQ NEMVRELDGH
970 980 990 1000 1010 1020
VLKCVKDQNG NHVVQKCIEC VQPQSLQFII DAFKGQVFAL STHPYGCRVI QRILEHCLPD
1030 1040 1050 1060 1070 1080
QTLPILEELH QHTEQLVQDQ YGNYVIQHVL EHGRPEDKSK IVAEIRGNVL VLSQHKFASN
1090 1100 1110 1120 1130 1140
VVEKCVTHAS RTERAVLIDE VCTMNDGPHS ALYTMMKDQY ANYVVQKMID VAEPGQRKIV
1150 1160 1170 1180
MHKIRPHIAT LRKYTYGKHI LAKLEKYYMK NGVDLGPICG PPNGII
Isoforms
- Isoform 2 of Pumilio homolog 1 - Isoform 3 of Pumilio homolog 1 - Isoform 4 of Pumilio homolog 1Sequence View
10 20 30 40 50 60
MSVACVLKRK AVLWQDSFSP HLKHHPQEPA NPNMPVVLTS GTGSQAQPQP AANQALAAGT
70 80 90 100 110 120
HSSPVPGSIG VAGRSQDDAM VDYFFQRQHG EQLGGGGSGG GGYNNSKHRW PTGDNIHAEH
130 140 150 160 170 180
QVRSMDELNH DFQALALEGR AMGEQLLPGK KFWETDESSK DGPKGIFLGD QWRDSAWGTS
190 200 210 220 230 240
DHSVSQPIMV QRRPGQSFHV NSEVNSVLSP RSESGGLGVS MVEYVLSSSP GDSCLRKGGF
250 260 270 280 290 300
GPRDADSDEN DKGEKKNKGT FDGDKLGDLK EEGDVMDKTN GLPVQNGIDA DVKDFSRTPG
310 320 330 340 350 360
NCQNSANEVD LLGPNQNGSE GLAQLTSTNG AKPVEDFSNM ESQSVPLDPM EHVGMEPLQF
370 380 390 400 410 420
DYSGTQVPVD SAAATVGLFD YNSQQQLFQR PNALAVQQLT AAQQQQYALA AAHQPHIGLA
430 440 450 460 470 480
PAAFVPNPYI ISAAPPGTDP YTAGLAAAAT LGPAVVPHQY YGVTPWGVYP ASLFQQQAAA
490 500 510 520 530 540
AAAATNSANQ QTTPQAQQGQ QQVLRGGASQ RPLTPNQNQQ GQQTDPLVAA AAVNSALAFG
550 560 570 580 590 600
QGLAAGMPGY PVLAPAAYYD QTGALVVNAG ARNGLGAPVR LVAPAPVIIS SSAAQAAVAA
610 620 630 640 650 660
AAASANGAAG GLAGTTNGPF RPLGTQQPQP QPQQQPNNNL ASSSFYGNNS LNSNSQSSSL
670 680 690 700 710 720
FSQGSAQPAN TSLGFGSSSS LGATLGSALG GFGTAVANSN TGSGSRRDSL TGSSDLYKRT
730 740 750 760 770 780
SSSLTPIGHS FYNGLSFSSS PGPVGMPLPS QGPGHSQTPP PSLSSHGSSS SLNLGGLTNG
790 800 810 820 830 840
SGRYISAAPG AEAKYRSASS ASSLFSPSST LFSSSRLRYG MSDVMPSGRS RLLEDFRNNR
850 860 870 880 890 900
YPNLQLREIA GHIMEFSQDQ HGSRFIQLKL ERATPAERQL VFNEILQAAY QLMVDVFGNY
910 920 930 940 950 960
VIQKFFEFGS LEQKLALAER IRGHVLSLAL QMYGCRVIQK ALEFIPSDQQ NEMVRELDGH
970 980 990 1000 1010 1020
VLKCVKDQNG NHVVQKCIEC VQPQSLQFII DAFKGQVFAL STHPYGCRVI QRILEHCLPD
1030 1040 1050 1060 1070 1080
QTLPILEELH QHTEQLVQDQ YGNYVIQHVL EHGRPEDKSK IVAEIRGNVL VLSQHKFASN
1090 1100 1110 1120 1130 1140
VVEKCVTHAS RTERAVLIDE VCTMNDGPHS ALYTMMKDQY ANYVVQKMID VAEPGQRKIV
1150 1160 1170 1180
MHKIRPHIAT LRKYTYGKHI LAKLEKYYMK NGVDLGPICG PPNGII
10 20 30 40 50 60
MSVACVLKRK AVLWQDSFSP HLKHHPQEPA NPNMPVVLTS GTGSQAQPQP AANQALAAGT
70 80 90 100 110 120
HSSPVPGSIG VAGRSQDDAM VDYFFQRQHG EQLGGGGSGG GGYNNSKHRW PTGDNIHAEH
130 140 150 160 170 180
QVRSMDELNH DFQALALEGR AMGEQLLPGK KFWETDESSK DGPKGIFLGD QWRDSAWGTS
190 200 210 220 230 240
DHSVSQPIMV QRRPGQSFHV NSEVNSVLSP RSESGGLGVS MVEYVLSSSP GDSCLRKGGF
250 260 270 280 290 300
GPRDADSDEN DKGEKKNKGT FDGDKLGDLK EEGDVMDKTN GLPVQNGIDA DVKDFSRTPG
310 320 330 340 350 360
NCQNSANEVD LLGPNQNGSE GLAQLTSTNG AKPVEDFSNM ESQSVPLDPM EHVGMEPLQF
370 380 390 400 410 420
DYSGTQVPVD SAAATVGLFD YNSQQQLFQR PNALAVQQLT AAQQQQYALA AAHQPHIGLA
430 440 450 460 470 480
PAAFVPNPYI ISAAPPGTDP YTAGLAAAAT LGPAVVPHQY YGVTPWGVYP ASLFQQQAAA
490 500 510 520 530 540
AAAATNSANQ QTTPQAQQGQ QQVLRGGASQ RPLTPNQNQQ GQQTDPLVAA AAVNSALAFG
550 560 570 580 590 600
QGLAAGMPGY PVLAPAAYYD QTGALVVNAG ARNGLGAPVR LVAPAPVIIS SSAAQAAVAA
610 620 630 640 650 660
AAASANGAAG GLAGTTNGPF RPLGTQQPQP QPQQQPNNNL ASSSFYGNNS LNSNSQSSSL
670 680 690 700 710 720
FSQGSAQPAN TSLGFGSSSS LGATLGSALG GFGTAVANSN TGSGSRRDSL TGSSDLYKRT
730 740 750 760 770 780
SSSLTPIGHS FYNGLSFSSS PGPVGMPLPS QGPGHSQTPP PSLSSHGSSS SLNLGGLTNG
790 800 810 820 830 840
SGRYISAAPG AEAKYRSASS ASSLFSPSST LFSSSRLRYG MSDVMPSGRS RLLEDFRNNR
850 860 870 880 890 900
YPNLQLREIA GHIMEFSQDQ HGSRFIQLKL ERATPAERQL VFNEILQAAY QLMVDVFGNY
910 920 930 940 950 960
VIQKFFEFGS LEQKLALAER IRGHVLSLAL QMYGCRVIQK ALEFIPSDQQ NEMVRELDGH
970 980 990 1000 1010 1020
VLKCVKDQNG NHVVQKCIEC VQPQSLQFII DAFKGQVFAL STHPYGCRVI QRILEHCLPD
1030 1040 1050 1060 1070 1080
QTLPILEELH QHTEQLVQDQ YGNYVIQHVL EHGRPEDKSK IVAEIRGNVL VLSQHKFASN
1090 1100 1110 1120 1130 1140
VVEKCVTHAS RTERAVLIDE VCTMNDGPHS ALYTMMKDQY ANYVVQKMID VAEPGQRKIV
1150 1160 1170 1180
MHKIRPHIAT LRKYTYGKHI LAKLEKYYMK NGVDLGPICG PPNGII
10 20 30 40 50 60
MSVACVLKRK AVLWQDSFSP HLKHHPQEPA NPNMPVVLTS GTGSQAQPQP AANQALAAGT
70 80 90 100 110 120
HSSPVPGSIG VAGRSQDDAM VDYFFQRQHG EQLGGGGSGG GGYNNSKHRW PTGDNIHAEH
130 140 150 160 170 180
QVRSMDELNH DFQALALEGR AMGEQLLPGK KFWETDESSK DGPKGIFLGD QWRDSAWGTS
190 200 210 220 230 240
DHSVSQPIMV QRRPGQSFHV NSEVNSVLSP RSESGGLGVS MVEYVLSSSP GDSCLRKGGF
250 260 270 280 290 300
GPRDADSDEN DKGEKKNKGT FDGDKLGDLK EEGDVMDKTN GLPVQNGIDA DVKDFSRTPG
310 320 330 340 350 360
NCQNSANEVD LLGPNQNGSE GLAQLTSTNG AKPVEDFSNM ESQSVPLDPM EHVGMEPLQF
370 380 390 400 410 420
DYSGTQVPVD SAAATVGLFD YNSQQQLFQR PNALAVQQLT AAQQQQYALA AAHQPHIGLA
430 440 450 460 470 480
PAAFVPNPYI ISAAPPGTDP YTAGLAAAAT LGPAVVPHQY YGVTPWGVYP ASLFQQQAAA
490 500 510 520 530 540
AAAATNSANQ QTTPQAQQGQ QQVLRGGASQ RPLTPNQNQQ GQQTDPLVAA AAVNSALAFG
550 560 570 580 590 600
QGLAAGMPGY PVLAPAAYYD QTGALVVNAG ARNGLGAPVR LVAPAPVIIS SSAAQAAVAA
610 620 630 640 650 660
AAASANGAAG GLAGTTNGPF RPLGTQQPQP QPQQQPNNNL ASSSFYGNNS LNSNSQSSSL
670 680 690 700 710 720
FSQGSAQPAN TSLGFGSSSS LGATLGSALG GFGTAVANSN TGSGSRRDSL TGSSDLYKRT
730 740 750 760 770 780
SSSLTPIGHS FYNGLSFSSS PGPVGMPLPS QGPGHSQTPP PSLSSHGSSS SLNLGGLTNG
790 800 810 820 830 840
SGRYISAAPG AEAKYRSASS ASSLFSPSST LFSSSRLRYG MSDVMPSGRS RLLEDFRNNR
850 860 870 880 890 900
YPNLQLREIA GHIMEFSQDQ HGSRFIQLKL ERATPAERQL VFNEILQAAY QLMVDVFGNY
910 920 930 940 950 960
VIQKFFEFGS LEQKLALAER IRGHVLSLAL QMYGCRVIQK ALEFIPSDQQ NEMVRELDGH
970 980 990 1000 1010 1020
VLKCVKDQNG NHVVQKCIEC VQPQSLQFII DAFKGQVFAL STHPYGCRVI QRILEHCLPD
1030 1040 1050 1060 1070 1080
QTLPILEELH QHTEQLVQDQ YGNYVIQHVL EHGRPEDKSK IVAEIRGNVL VLSQHKFASN
1090 1100 1110 1120 1130 1140
VVEKCVTHAS RTERAVLIDE VCTMNDGPHS ALYTMMKDQY ANYVVQKMID VAEPGQRKIV
1150 1160 1170 1180
MHKIRPHIAT LRKYTYGKHI LAKLEKYYMK NGVDLGPICG PPNGII
Protein Neighborhood
Domains & Features
13 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
Q14671-2-unknown | MSVACV... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
Q14671-1-unknown | MSVACV... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt86650 | |||
Q14671-1-unknown | MSVACV... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt86651 | |||
Q14671-1-unknown | MSVACV... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt97796 | |||
Q14671-2-Acetylation | SVACVL... | 2 | acetylation- | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | ||
Q14671-2-Acetylation | SVACVL... | 2 | acetylation- | COFRADIC | Gevaert K. | Van Damme P et al.: Complementary positional proteomics for screening substrates... | 20526345 | ||
Q14671-2-Acetylation | SVACVL... | 2 | acetylation- | COFRADIC | Gevaert K. | Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates... | 20526345 | ||
Q14671-2-Acetylation | SVACVL... | 2 | acetylation- | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt110268 | ||
Q14671-2-Acetylation | SVACVL... | 2 | acetylation- | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt110269 | ||
Q14671-2-Acetylation | SVACVL... | 2 | acetylation- | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt110267 | ||
Q14671-34-unknown | MPVVLT... | 34 | inferred from electronic annotation | unknown | TISdb | inferred from TISdb | |||
Q14671-34-unknown | MPVVLT... | 34 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt195744 | |||
Q14671-34-unknown | MPVVLT... | 34 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt195745 | |||
Q14671-34-unknown | MPVVLT... | 34 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt195743 | |||
Q14671-36- | VVLTSG... | 36 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
Q14671-36-unknown | VVLTSG... | 36 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt174099 | |||
Q14671-36-unknown | VVLTSG... | 36 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt174100 | |||
Q14671-36-unknown | VVLTSG... | 36 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt174098 | |||
Q14671-62-unknown | SSPVPG... | 62 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt168344 | |||
Q14671-62-unknown | SSPVPG... | 62 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt168345 | |||
Q14671-62-unknown | SSPVPG... | 62 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt168343 | |||
Q14671-62- | SSPVPG... | 62 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
Q14671-281- | GLPVQN... | 281 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 | |||
Q14671-281-unknown | GLPVQN... | 281 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt176958 | |||
Q14671-281-unknown | GLPVQN... | 281 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt176959 | |||
Q14671-281-unknown | GLPVQN... | 281 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt176960 | |||
Q14671-287- | GIDADV... | 287 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
Q14671-287-unknown | GIDADV... | 287 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt172885 | |||
Q14671-287-unknown | GIDADV... | 287 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt172886 | |||
Q14671-287-unknown | GIDADV... | 287 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt172887 | |||
Q14671-292-unknown | VKDFSR... | 292 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC12244 | |||
Q14671-292-unknown | VKDFSR... | 292 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt147819 | |||
Q14671-292-unknown | VKDFSR... | 292 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt149661 | |||
Q14671-292-unknown | VKDFSR... | 292 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt149662 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...GIDADV | 291 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC12244 | |||
...GIDADV | 291 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt131174 | |||
...GIDADV | 291 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt133048 | |||
...GIDADV | 291 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt133049 | |||
...PNGII | 1186 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...PNGII | 1186 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt82270 | |||
...PNGII | 1186 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt82268 | |||
...PNGII | 1186 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt82269 |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
GRAB_HUMAN | 291 | DADV.|.VKDF | inferred from experiment | unknown | MEROPS | Gevaert K | Van Damme P et al.:Complementary positional proteo... (M14.017) | 20526345, |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|