Q14676: Mediator of DNA damage checkpoint protein 1

General Information

Protein names	- Mediator of DNA damage checkpoint protein 1 - Nuclear factor with BRCT domains 1
Gene names	MDC1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q14676

12 N-termini

8 C-termini

3 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Mediator of DNA damage checkpoint protein 1 - Isoform 3 of Mediator of DNA damage checkpoint protein 1 - Isoform 4 of Mediator of DNA damage checkpoint protein 1

Sequence View

        10         20         30         40         50         60
MEDTQAIDWD VEEEEETEQS SESLRCNVEP VGRLHIFSGA HGPEKDFPLH LGKNVVGRMP
        70         80         90        100        110        120
DCSVALPFPS ISKQHAEIEI LAWDKAPILR DCGSLNGTQI LRPPKVLSPG VSHRLRDQEL
       130        140        150        160        170        180
ILFADLLCQY HRLDVSLPFV SRGPLTVEET PRVQGETQPQ RLLLAEDSEE EVDFLSERRM
       190        200        210        220        230        240
VKKSRTTSSS VIVPESDEEG HSPVLGGLGP PFAFNLNSDT DVEEGQQPAT EEASSAARRG
       250        260        270        280        290        300
ATVEAKQSEA EVVTEIQLEK DQPLVKERDN DTKVKRGAGN GVVPAGVILE RSQPPGEDSD
       310        320        330        340        350        360
TDVDDDSRPP GRPAEVHLER AQPFGFIDSD TDAEEERIPA TPVVIPMKKR KIFHGVGTRG
       370        380        390        400        410        420
PGAPGLAHLQ ESQAGSDTDV EEGKAPQAVP LEKSQASMVI NSDTDDEEEV SAALTLAHLK
       430        440        450        460        470        480
ESQPAIWNRD AEEDMPQRVV LLQRSQTTTE RDSDTDVEEE ELPVENREAV LKDHTKIRAL
       490        500        510        520        530        540
VRAHSEKDQP PFGDSDDSVE ADKSSPGIHL ERSQASTTVD INTQVEKEVP PGSAIIHIKK
       550        560        570        580        590        600
HQVSVEGTNQ TDVKAVGGPA KLLVVSLEEA WPLHGDCETD AEEGTSLTAS VVADVRKSQL
       610        620        630        640        650        660
PAEGDAGAEW AAAVLKQERA HEVGAQGGPP VAQVEQDLPI SRENLTDLVV DTDTLGESTQ
       670        680        690        700        710        720
PQREGAQVPT GREREQHVGG TKDSEDNYGD SEDLDLQATQ CFLENQGLEA VQSMEDEPTQ
       730        740        750        760        770        780
AFMLTPPQEL GPSHCSFQTT GTLDEPWEVL ATQPFCLRES EDSETQPFDT HLEAYGPCLS
       790        800        810        820        830        840
PPRAIPGDQH PESPVHTEPM GIQGRGRQTV DKVMGIPKET AERVGPERGP LERETEKLLP
       850        860        870        880        890        900
ERQTDVTGEE ELTKGKQDRE QKQLLARDTQ RQESDKNGES ASPERDRESL KVEIETSEEI
       910        920        930        940        950        960
QEKQVQKQTL PSKAFEREVE RPVANRECDP AELEEKVPKV ILERDTQRGE PEGGSQDQKG
       970        980        990       1000       1010       1020
QASSPTPEPG VGAGDLPGPT SAPVPSGSQS GGRGSPVSPR RHQKGLLNCK MPPAEKASRI
      1030       1040       1050       1060       1070       1080
RAAEKVSRGD QESPDACLPP TVPEAPAPPQ KPLNSQSQKH LAPPPLLSPL LPSIKPTVRK
      1090       1100       1110       1120       1130       1140
TRQDGSQEAP EAPLSSELEP FHPKPKIRTR KSSRMTPFPA TSAAPEPHPS TSTAQPVTPK
      1150       1160       1170       1180       1190       1200
PTSQATRSRT NRSSVKTPEP VVPTAPELQP STSTDQPVTS EPTSQVTRGR KSRSSVKTPE
      1210       1220       1230       1240       1250       1260
TVVPTALELQ PSTSTDRPVT SEPTSQATRG RKNRSSVKTP EPVVPTAPEL QPSTSTDQPV
      1270       1280       1290       1300       1310       1320
TSEPTYQATR GRKNRSSVKT PEPVVPTAPE LRPSTSTDRP VTPKPTSRTT RSRTNMSSVK
      1330       1340       1350       1360       1370       1380
TPETVVPTAP ELQISTSTDQ PVTPKPTSRT TRSRTNMSSV KNPESTVPIA PELPPSTSTE
      1390       1400       1410       1420       1430       1440
QPVTPEPTSR ATRGRKNRSS GKTPETLVPT APKLEPSTST DQPVTPEPTS QATRGRTNRS
      1450       1460       1470       1480       1490       1500
SVKTPETVVP TAPELQPSTS TDQPVTPEPT SQATRGRTDR SSVKTPETVV PTAPELQASA
      1510       1520       1530       1540       1550       1560
STDQPVTSEP TSRTTRGRKN RSSVKTPETV VPAAPELQPS TSTDQPVTPE PTSRATRGRT
      1570       1580       1590       1600       1610       1620
NRSSVKTPES IVPIAPELQP STSRNQLVTP EPTSRATRCR TNRSSVKTPE PVVPTAPEPH
      1630       1640       1650       1660       1670       1680
PTTSTDQPVT PKLTSRATRR KTNRSSVKTP KPVEPAASDL EPFTPTDQSV TPEAIAQGGQ
      1690       1700       1710       1720       1730       1740
SKTLRSSTVR AMPVPTTPEF QSPVTTDQPI SPEPITQPSC IKRQRAAGNP GSLAAPIDHK
      1750       1760       1770       1780       1790       1800
PCSAPLEPKS QASRNQRWGA VRAAESLTAI PEPASPQLLE TPIHASQIQK VEPAGRSRFT
      1810       1820       1830       1840       1850       1860
PELQPKASQS RKRSLATMDS PPHQKQPQRG EVSQKTVIIK EEEEDTAEKP GKEEDVVTPK
      1870       1880       1890       1900       1910       1920
PGKRKRDQAE EEPNRIPSRS LRRTKLNQES TAPKVLFTGV VDARGERAVL ALGGSLAGSA
      1930       1940       1950       1960       1970       1980
AEASHLVTDR IRRTVKFLCA LGRGIPILSL DWLHQSRKAG FFLPPDEYVV TDPEQEKNFG
      1990       2000       2010       2020       2030       2040
FSLQDALSRA RERRLLEGYE IYVTPGVQPP PPQMGEIISC CGGTYLPSMP RSYKPQRVVI
      2050       2060       2070       2080
TCPQDFPHCS IPLRVGLPLL SPEFLLTGVL KQEAKPEAFV LSPLEMSST         10         20         30         40         50         60
MEDTQAIDWD VEEEEETEQS SESLRCNVEP VGRLHIFSGA HGPEKDFPLH LGKNVVGRMP
        70         80         90        100        110        120
DCSVALPFPS ISKQHAEIEI LAWDKAPILR DCGSLNGTQI LRPPKVLSPG VSHRLRDQEL
       130        140        150        160        170        180
ILFADLLCQY HRLDVSLPFV SRGPLTVEET PRVQGETQPQ RLLLAEDSEE EVDFLSERRM
       190        200        210        220        230        240
VKKSRTTSSS VIVPESDEEG HSPVLGGLGP PFAFNLNSDT DVEEGQQPAT EEASSAARRG
       250        260        270        280        290        300
ATVEAKQSEA EVVTEIQLEK DQPLVKERDN DTKVKRGAGN GVVPAGVILE RSQPPGEDSD
       310        320        330        340        350        360
TDVDDDSRPP GRPAEVHLER AQPFGFIDSD TDAEEERIPA TPVVIPMKKR KIFHGVGTRG
       370        380        390        400        410        420
PGAPGLAHLQ ESQAGSDTDV EEGKAPQAVP LEKSQASMVI NSDTDDEEEV SAALTLAHLK
       430        440        450        460        470        480
ESQPAIWNRD AEEDMPQRVV LLQRSQTTTE RDSDTDVEEE ELPVENREAV LKDHTKIRAL
       490        500        510        520        530        540
VRAHSEKDQP PFGDSDDSVE ADKSSPGIHL ERSQASTTVD INTQVEKEVP PGSAIIHIKK
       550        560        570        580        590        600
HQVSVEGTNQ TDVKAVGGPA KLLVVSLEEA WPLHGDCETD AEEGTSLTAS VVADVRKSQL
       610        620        630        640        650        660
PAEGDAGAEW AAAVLKQERA HEVGAQGGPP VAQVEQDLPI SRENLTDLVV DTDTLGESTQ
       670        680        690        700        710        720
PQREGAQVPT GREREQHVGG TKDSEDNYGD SEDLDLQATQ CFLENQGLEA VQSMEDEPTQ
       730        740        750        760        770        780
AFMLTPPQEL GPSHCSFQTT GTLDEPWEVL ATQPFCLRES EDSETQPFDT HLEAYGPCLS
       790        800        810        820        830        840
PPRAIPGDQH PESPVHTEPM GIQGRGRQTV DKVMGIPKET AERVGPERGP LERETEKLLP
       850        860        870        880        890        900
ERQTDVTGEE ELTKGKQDRE QKQLLARDTQ RQESDKNGES ASPERDRESL KVEIETSEEI
       910        920        930        940        950        960
QEKQVQKQTL PSKAFEREVE RPVANRECDP AELEEKVPKV ILERDTQRGE PEGGSQDQKG
       970        980        990       1000       1010       1020
QASSPTPEPG VGAGDLPGPT SAPVPSGSQS GGRGSPVSPR RHQKGLLNCK MPPAEKASRI
      1030       1040       1050       1060       1070       1080
RAAEKVSRGD QESPDACLPP TVPEAPAPPQ KPLNSQSQKH LAPPPLLSPL LPSIKPTVRK
      1090       1100       1110       1120       1130       1140
TRQDGSQEAP EAPLSSELEP FHPKPKIRTR KSSRMTPFPA TSAAPEPHPS TSTAQPVTPK
      1150       1160       1170       1180       1190       1200
PTSQATRSRT NRSSVKTPEP VVPTAPELQP STSTDQPVTS EPTSQVTRGR KSRSSVKTPE
      1210       1220       1230       1240       1250       1260
TVVPTALELQ PSTSTDRPVT SEPTSQATRG RKNRSSVKTP EPVVPTAPEL QPSTSTDQPV
      1270       1280       1290       1300       1310       1320
TSEPTYQATR GRKNRSSVKT PEPVVPTAPE LRPSTSTDRP VTPKPTSRTT RSRTNMSSVK
      1330       1340       1350       1360       1370       1380
TPETVVPTAP ELQISTSTDQ PVTPKPTSRT TRSRTNMSSV KNPESTVPIA PELPPSTSTE
      1390       1400       1410       1420       1430       1440
QPVTPEPTSR ATRGRKNRSS GKTPETLVPT APKLEPSTST DQPVTPEPTS QATRGRTNRS
      1450       1460       1470       1480       1490       1500
SVKTPETVVP TAPELQPSTS TDQPVTPEPT SQATRGRTDR SSVKTPETVV PTAPELQASA
      1510       1520       1530       1540       1550       1560
STDQPVTSEP TSRTTRGRKN RSSVKTPETV VPAAPELQPS TSTDQPVTPE PTSRATRGRT
      1570       1580       1590       1600       1610       1620
NRSSVKTPES IVPIAPELQP STSRNQLVTP EPTSRATRCR TNRSSVKTPE PVVPTAPEPH
      1630       1640       1650       1660       1670       1680
PTTSTDQPVT PKLTSRATRR KTNRSSVKTP KPVEPAASDL EPFTPTDQSV TPEAIAQGGQ
      1690       1700       1710       1720       1730       1740
SKTLRSSTVR AMPVPTTPEF QSPVTTDQPI SPEPITQPSC IKRQRAAGNP GSLAAPIDHK
      1750       1760       1770       1780       1790       1800
PCSAPLEPKS QASRNQRWGA VRAAESLTAI PEPASPQLLE TPIHASQIQK VEPAGRSRFT
      1810       1820       1830       1840       1850       1860
PELQPKASQS RKRSLATMDS PPHQKQPQRG EVSQKTVIIK EEEEDTAEKP GKEEDVVTPK
      1870       1880       1890       1900       1910       1920
PGKRKRDQAE EEPNRIPSRS LRRTKLNQES TAPKVLFTGV VDARGERAVL ALGGSLAGSA
      1930       1940       1950       1960       1970       1980
AEASHLVTDR IRRTVKFLCA LGRGIPILSL DWLHQSRKAG FFLPPDEYVV TDPEQEKNFG
      1990       2000       2010       2020       2030       2040
FSLQDALSRA RERRLLEGYE IYVTPGVQPP PPQMGEIISC CGGTYLPSMP RSYKPQRVVI
      2050       2060       2070       2080
TCPQDFPHCS IPLRVGLPLL SPEFLLTGVL KQEAKPEAFV LSPLEMSST         10         20         30         40         50         60
MEDTQAIDWD VEEEEETEQS SESLRCNVEP VGRLHIFSGA HGPEKDFPLH LGKNVVGRMP
        70         80         90        100        110        120
DCSVALPFPS ISKQHAEIEI LAWDKAPILR DCGSLNGTQI LRPPKVLSPG VSHRLRDQEL
       130        140        150        160        170        180
ILFADLLCQY HRLDVSLPFV SRGPLTVEET PRVQGETQPQ RLLLAEDSEE EVDFLSERRM
       190        200        210        220        230        240
VKKSRTTSSS VIVPESDEEG HSPVLGGLGP PFAFNLNSDT DVEEGQQPAT EEASSAARRG
       250        260        270        280        290        300
ATVEAKQSEA EVVTEIQLEK DQPLVKERDN DTKVKRGAGN GVVPAGVILE RSQPPGEDSD
       310        320        330        340        350        360
TDVDDDSRPP GRPAEVHLER AQPFGFIDSD TDAEEERIPA TPVVIPMKKR KIFHGVGTRG
       370        380        390        400        410        420
PGAPGLAHLQ ESQAGSDTDV EEGKAPQAVP LEKSQASMVI NSDTDDEEEV SAALTLAHLK
       430        440        450        460        470        480
ESQPAIWNRD AEEDMPQRVV LLQRSQTTTE RDSDTDVEEE ELPVENREAV LKDHTKIRAL
       490        500        510        520        530        540
VRAHSEKDQP PFGDSDDSVE ADKSSPGIHL ERSQASTTVD INTQVEKEVP PGSAIIHIKK
       550        560        570        580        590        600
HQVSVEGTNQ TDVKAVGGPA KLLVVSLEEA WPLHGDCETD AEEGTSLTAS VVADVRKSQL
       610        620        630        640        650        660
PAEGDAGAEW AAAVLKQERA HEVGAQGGPP VAQVEQDLPI SRENLTDLVV DTDTLGESTQ
       670        680        690        700        710        720
PQREGAQVPT GREREQHVGG TKDSEDNYGD SEDLDLQATQ CFLENQGLEA VQSMEDEPTQ
       730        740        750        760        770        780
AFMLTPPQEL GPSHCSFQTT GTLDEPWEVL ATQPFCLRES EDSETQPFDT HLEAYGPCLS
       790        800        810        820        830        840
PPRAIPGDQH PESPVHTEPM GIQGRGRQTV DKVMGIPKET AERVGPERGP LERETEKLLP
       850        860        870        880        890        900
ERQTDVTGEE ELTKGKQDRE QKQLLARDTQ RQESDKNGES ASPERDRESL KVEIETSEEI
       910        920        930        940        950        960
QEKQVQKQTL PSKAFEREVE RPVANRECDP AELEEKVPKV ILERDTQRGE PEGGSQDQKG
       970        980        990       1000       1010       1020
QASSPTPEPG VGAGDLPGPT SAPVPSGSQS GGRGSPVSPR RHQKGLLNCK MPPAEKASRI
      1030       1040       1050       1060       1070       1080
RAAEKVSRGD QESPDACLPP TVPEAPAPPQ KPLNSQSQKH LAPPPLLSPL LPSIKPTVRK
      1090       1100       1110       1120       1130       1140
TRQDGSQEAP EAPLSSELEP FHPKPKIRTR KSSRMTPFPA TSAAPEPHPS TSTAQPVTPK
      1150       1160       1170       1180       1190       1200
PTSQATRSRT NRSSVKTPEP VVPTAPELQP STSTDQPVTS EPTSQVTRGR KSRSSVKTPE
      1210       1220       1230       1240       1250       1260
TVVPTALELQ PSTSTDRPVT SEPTSQATRG RKNRSSVKTP EPVVPTAPEL QPSTSTDQPV
      1270       1280       1290       1300       1310       1320
TSEPTYQATR GRKNRSSVKT PEPVVPTAPE LRPSTSTDRP VTPKPTSRTT RSRTNMSSVK
      1330       1340       1350       1360       1370       1380
TPETVVPTAP ELQISTSTDQ PVTPKPTSRT TRSRTNMSSV KNPESTVPIA PELPPSTSTE
      1390       1400       1410       1420       1430       1440
QPVTPEPTSR ATRGRKNRSS GKTPETLVPT APKLEPSTST DQPVTPEPTS QATRGRTNRS
      1450       1460       1470       1480       1490       1500
SVKTPETVVP TAPELQPSTS TDQPVTPEPT SQATRGRTDR SSVKTPETVV PTAPELQASA
      1510       1520       1530       1540       1550       1560
STDQPVTSEP TSRTTRGRKN RSSVKTPETV VPAAPELQPS TSTDQPVTPE PTSRATRGRT
      1570       1580       1590       1600       1610       1620
NRSSVKTPES IVPIAPELQP STSRNQLVTP EPTSRATRCR TNRSSVKTPE PVVPTAPEPH
      1630       1640       1650       1660       1670       1680
PTTSTDQPVT PKLTSRATRR KTNRSSVKTP KPVEPAASDL EPFTPTDQSV TPEAIAQGGQ
      1690       1700       1710       1720       1730       1740
SKTLRSSTVR AMPVPTTPEF QSPVTTDQPI SPEPITQPSC IKRQRAAGNP GSLAAPIDHK
      1750       1760       1770       1780       1790       1800
PCSAPLEPKS QASRNQRWGA VRAAESLTAI PEPASPQLLE TPIHASQIQK VEPAGRSRFT
      1810       1820       1830       1840       1850       1860
PELQPKASQS RKRSLATMDS PPHQKQPQRG EVSQKTVIIK EEEEDTAEKP GKEEDVVTPK
      1870       1880       1890       1900       1910       1920
PGKRKRDQAE EEPNRIPSRS LRRTKLNQES TAPKVLFTGV VDARGERAVL ALGGSLAGSA
      1930       1940       1950       1960       1970       1980
AEASHLVTDR IRRTVKFLCA LGRGIPILSL DWLHQSRKAG FFLPPDEYVV TDPEQEKNFG
      1990       2000       2010       2020       2030       2040
FSLQDALSRA RERRLLEGYE IYVTPGVQPP PPQMGEIISC CGGTYLPSMP RSYKPQRVVI
      2050       2060       2070       2080
TCPQDFPHCS IPLRVGLPLL SPEFLLTGVL KQEAKPEAFV LSPLEMSST

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

12 N-termini - 8 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q14676-1-unknown	MEDTQA...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q14676-1-unknown	MEDTQA...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt80703
Q14676-1-unknown	MEDTQA...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt80704
Q14676-1-unknown	MEDTQA...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt80705
Q14676-281-unknown	GVVPAG...	281	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt166857
Q14676-281-unknown	GVVPAG...	281	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt166858
Q14676-281-unknown	GVVPAG...	281	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt166859
Q14676-281-	GVVPAG...	281		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q14676-281-	GVVPAG...	281		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q14676-281-	GVVPAG...	281		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q14676-281-	GVVPAG...	281		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q14676-453-unknown	SDTDVE...	453	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176849
Q14676-453-unknown	SDTDVE...	453	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176850
Q14676-453-unknown	SDTDVE...	453	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176851
Q14676-453-	SDTDVE...	453		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q14676-606-unknown	AGAEWA...	606	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12248
Q14676-606-unknown	AGAEWA...	606	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt154668
Q14676-606-unknown	AGAEWA...	606	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt154669
Q14676-606-unknown	AGAEWA...	606	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt154670
Q14676-625-unknown	AQGGPP...	625	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173724
Q14676-625-unknown	AQGGPP...	625	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173725
Q14676-625-unknown	AQGGPP...	625	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173726
Q14676-625-	AQGGPP...	625		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q14676-625-	AQGGPP...	625		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q14676-625-	AQGGPP...	625		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q14676-652-unknown	TDTLGE...	652	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12252
Q14676-652-unknown	TDTLGE...	652	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt155347
Q14676-652-unknown	TDTLGE...	652	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt155348
Q14676-652-unknown	TDTLGE...	652	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt155349
Q14676-654-unknown	TLGEST...	654	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12256
Q14676-654-unknown	TLGEST...	654	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt155368
Q14676-654-unknown	TLGEST...	654	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt155369
Q14676-654-unknown	TLGEST...	654	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt155370
Q14676-1769-unknown	AIPEPA...	1769	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt166854
Q14676-1769-unknown	AIPEPA...	1769	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt166855
Q14676-1769-	AIPEPA...	1769		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PGVSHR	113	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000390040
...PGVSHR	113	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000414163
...PGVSHR	113	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154504
...PGVSHR	113	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154505
...PGVSHR	113	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154506
...LFADLL	126	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000405991
...LFADLL	126	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000410383
...LFADLL	126	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154699
...LFADLL	126	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154700
...LFADLL	126	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154701
...QPQRLL	162	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000392784
...QPQRLL	162	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000392833
...QPQRLL	162	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155121
...QPQRLL	162	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155122
...QPQRLL	162	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155123
...ATVEAK	245	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000447136
...ATVEAK	245	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000450037
...PAEGDA	605	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12248
...PAEGDA	605	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt138093
...PAEGDA	605	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt138094
...PAEGDA	605	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt138095
...DLVVDT	651	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12252
...DLVVDT	651	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt138780
...DLVVDT	651	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt138781
...DLVVDT	651	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt138782
...VVDTDT	653	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12256
...VVDTDT	653	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt138803
...VVDTDT	653	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt138804
...VVDTDT	653	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt138805
...EMSST	2089	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...EMSST	2089	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt76323
...EMSST	2089	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt76322
...EMSST	2089	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt76321

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	605	EGDA.\|.AGAE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAB_HUMAN	651	VVDT.\|.TDTL	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
GRAB_HUMAN	653	DTDT.\|.TLGE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)