Q15003: Condensin complex subunit 2

General Information

Protein names	- Condensin complex subunit 2 - Barren homolog protein 1 - Chromosome-associated protein H - hCAP-H - Non-SMC condensin I complex subunit H - XCAP-H homolog
Gene names	NCAPH
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q15003

18 N-termini

4 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MGPPGPALPA TMNNSSSETR GHPHSASSPS ERVFPMPLPR KAPLNIPGTP VLEDFPQNDD
        70         80         90        100        110        120
EKERLQRRRS RVFDLQFSTD SPRLLASPSS RSIDISATIP KFTNTQITEH YSTCIKLSTE
       130        140        150        160        170        180
NKITTKNAFG LHLIDFMSEI LKQKDTEPTN FKVAAGTLDA STKIYAVRVD AVHADVYRVL
       190        200        210        220        230        240
GGLGKDAPSL EEVEGHVADG SATEMGTTKK AVKPKKKHLH RTIEQNINNL NVSEADRKCE
       250        260        270        280        290        300
IDPMFQKTAA SFDECSTAGV FLSTLHCQDY RSELLFPSDV QTLSTGEPLE LPELGCVEMT
       310        320        330        340        350        360
DLKAPLQQCA EDRQICPSLA GFQFTQWDSE THNESVSALV DKFKKNDQVF DINAEVDESD
       370        380        390        400        410        420
CGDFPDGSLG DDFDANDEPD HTAVGDHEEF RSWKEPCQVQ SCQEEMISLG DGDIRTMCPL
       430        440        450        460        470        480
LSMKPGEYSY FSPRTMSMWA GPDHWRFRPR RKQDAPSQSE NKKKSTKKDF EIDFEDDIDF
       490        500        510        520        530        540
DVYFRKTKAA TILTKSTLEN QNWRATTLPT DFNYNVDTLV QLHLKPGTRL LKMAQGHRVE
       550        560        570        580        590        600
TEHYEEIEDY DYNNPNDTSN FCPGLQAADS DDEDLDDLFV GPVGNSDLSP YPCHPPKTAQ
       610        620        630        640        650        660
QNGDTPEAQG LDITTYGESN LVAEPQKVNK IEIHYAKTAK KMDMKKLKQS MWSLLTALSG
       670        680        690        700        710        720
KEADAEANHR EAGKEAALAE VADEKMLSGL TKDLQRSLPP VMAQNLSIPL AFACLLHLAN
       730        740
EKNLKLEGTE DLSDVLVRQG D

Isoforms

- Isoform 2 of Condensin complex subunit 2

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

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Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

18 N-termini - 4 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q15003-1-unknown	MGPPGP...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q15003-2-	GPPGPA...	2		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q15003-2-unknown	GPPGPA...	2		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q15003-2-unknown	GPPGPA...	2		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q15003-7-unknown	ALPATM...	7		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q15003-7-unknown	ALPATM...	7		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q15003-7-	ALPATM...	7		Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
Q15003-7-	ALPATM...	7		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q15003-7-	ALPATM...	7		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_CD95	23264352
Q15003-7-	ALPATM...	7		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q15003-7-	ALPATM...	7		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q15003-7-	ALPATM...	7		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q15003-7-	ALPATM...	7		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q15003-7-	ALPATM...	7		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q15003-7-	ALPATM...	7		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q15003-12-unknown	MNNSSS...	12	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000407308
Q15003-137-unknown	MSEILK...	137	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000400774
Q15003-171-	AVHADV...	171		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q15003-195-	GHVADG...	195		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q15003-195-	GHVADG...	195		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q15003-195-	GHVADG...	195		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q15003-195-	GHVADG...	195		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q15003-195-	GHVADG...	195		Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
Q15003-195-	GHVADG...	195		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q15003-195-unknown	GHVADG...	195		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q15003-200-	GSATEM...	200		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q15003-200-	GSATEM...	200		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q15003-200-	GSATEM...	200		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q15003-200-unknown	GSATEM...	200		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q15003-367-	GSLGDD...	367		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q15003-367-	GSLGDD...	367		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q15003-381-	HTAVGD...	381		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q15003-381-	HTAVGD...	381		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q15003-383-	AVGDHE...	383		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q15003-383-	AVGDHE...	383		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q15003-407-unknown	ISLGDG...	407	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14514
Q15003-422-	SMKPGE...	422		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q15003-422-	SMKPGE...	422		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q15003-659-unknown	SGKEAD...	659	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14515

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...CQEEMI	406	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14514
...TTYGES	618	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000405237
...LLTALS	658	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14515
...VRQGD	741	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	406	EEMI.\|.ISLG	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAM_HUMAN	658	TALS.\|.SGKE	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)