Q15020: Squamous cell carcinoma antigen recognized by T-cells 3 {ECO:0000305}

General Information

Protein names	- Squamous cell carcinoma antigen recognized by T-cells 3 {ECO:0000305} - SART-3 {ECO:0000312\|EMBL:BAA78384.1} - Tat-interacting protein of 110 kDa {ECO:0000303\|PubMed:11959860} - Tip110 {ECO:0000303\|PubMed:11959860} - p110 nuclear RNA-binding protein {ECO:0000303\|PubMed:12032085}
Gene names	SART3
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q15020

8 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Squamous cell carcinoma antigen recognized by T-cells 3 - Isoform 3 of Squamous cell carcinoma antigen recognized by T-cells 3 - Isoform 4 of Squamous cell carcinoma antigen recognized by T-cells 3

Sequence View

        10         20         30         40         50         60
MATAAETSAS EPEAESKAGP KADGEEDEVK AARTRRKVLS RAVAAATYKT MGPAWDQQEE
        70         80         90        100        110        120
GVSESDGDEY AMASSAESSP GEYEWEYDEE EEKNQLEIER LEEQLSINVY DYNCHVDLIR
       130        140        150        160        170        180
LLRLEGELTK VRMARQKMSE IFPLTEELWL EWLHDEISMA QDGLDREHVY DLFEKAVKDY
       190        200        210        220        230        240
ICPNIWLEYG QYSVGGIGQK GGLEKVRSVF ERALSSVGLH MTKGLALWEA YREFESAIVE
       250        260        270        280        290        300
AARLEKVHSL FRRQLAIPLY DMEATFAEYE EWSEDPIPES VIQNYNKALQ QLEKYKPYEE
       310        320        330        340        350        360
ALLQAEAPRL AEYQAYIDFE MKIGDPARIQ LIFERALVEN CLVPDLWIRY SQYLDRQLKV
       370        380        390        400        410        420
KDLVLSVHNR AIRNCPWTVA LWSRYLLAME RHGVDHQVIS VTFEKALNAG FIQATDYVEI
       430        440        450        460        470        480
WQAYLDYLRR RVDFKQDSSK ELEELRAAFT RALEYLKQEV EERFNESGDP SCVIMQNWAR
       490        500        510        520        530        540
IEARLCNNMQ KARELWDSIM TRGNAKYANM WLEYYNLERA HGDTQHCRKA LHRAVQCTSD
       550        560        570        580        590        600
YPEHVCEVLL TMERTEGSLE DWDIAVQKTE TRLARVNEQR MKAAEKEAAL VQQEEEKAEQ
       610        620        630        640        650        660
RKRARAEKKA LKKKKKIRGP EKRGADEDDE KEWGDDEEEQ PSKRRRVENS IPAAGETQNV
       670        680        690        700        710        720
EVAAGPAGKC AAVDVEPPSK QKEKAASLKR DMPKVLHDSS KDSITVFVSN LPYSMQEPDT
       730        740        750        760        770        780
KLRPLFEACG EVVQIRPIFS NRGDFRGYCY VEFKEEKSAL QALEMDRKSV EGRPMFVSPC
       790        800        810        820        830        840
VDKSKNPDFK VFRYSTSLEK HKLFISGLPF SCTKEELEEI CKAHGTVKDL RLVTNRAGKP
       850        860        870        880        890        900
KGLAYVEYEN ESQASQAVMK MDGMTIKENI IKVAISNPPQ RKVPEKPETR KAPGGPMLLP
       910        920        930        940        950        960
QTYGARGKGR TQLSLLPRAL QRPSAAAPQA ENGPAAAPAV AAPAATEAPK MSNADFAKLF

LRK         10         20         30         40         50         60
MATAAETSAS EPEAESKAGP KADGEEDEVK AARTRRKVLS RAVAAATYKT MGPAWDQQEE
        70         80         90        100        110        120
GVSESDGDEY AMASSAESSP GEYEWEYDEE EEKNQLEIER LEEQLSINVY DYNCHVDLIR
       130        140        150        160        170        180
LLRLEGELTK VRMARQKMSE IFPLTEELWL EWLHDEISMA QDGLDREHVY DLFEKAVKDY
       190        200        210        220        230        240
ICPNIWLEYG QYSVGGIGQK GGLEKVRSVF ERALSSVGLH MTKGLALWEA YREFESAIVE
       250        260        270        280        290        300
AARLEKVHSL FRRQLAIPLY DMEATFAEYE EWSEDPIPES VIQNYNKALQ QLEKYKPYEE
       310        320        330        340        350        360
ALLQAEAPRL AEYQAYIDFE MKIGDPARIQ LIFERALVEN CLVPDLWIRY SQYLDRQLKV
       370        380        390        400        410        420
KDLVLSVHNR AIRNCPWTVA LWSRYLLAME RHGVDHQVIS VTFEKALNAG FIQATDYVEI
       430        440        450        460        470        480
WQAYLDYLRR RVDFKQDSSK ELEELRAAFT RALEYLKQEV EERFNESGDP SCVIMQNWAR
       490        500        510        520        530        540
IEARLCNNMQ KARELWDSIM TRGNAKYANM WLEYYNLERA HGDTQHCRKA LHRAVQCTSD
       550        560        570        580        590        600
YPEHVCEVLL TMERTEGSLE DWDIAVQKTE TRLARVNEQR MKAAEKEAAL VQQEEEKAEQ
       610        620        630        640        650        660
RKRARAEKKA LKKKKKIRGP EKRGADEDDE KEWGDDEEEQ PSKRRRVENS IPAAGETQNV
       670        680        690        700        710        720
EVAAGPAGKC AAVDVEPPSK QKEKAASLKR DMPKVLHDSS KDSITVFVSN LPYSMQEPDT
       730        740        750        760        770        780
KLRPLFEACG EVVQIRPIFS NRGDFRGYCY VEFKEEKSAL QALEMDRKSV EGRPMFVSPC
       790        800        810        820        830        840
VDKSKNPDFK VFRYSTSLEK HKLFISGLPF SCTKEELEEI CKAHGTVKDL RLVTNRAGKP
       850        860        870        880        890        900
KGLAYVEYEN ESQASQAVMK MDGMTIKENI IKVAISNPPQ RKVPEKPETR KAPGGPMLLP
       910        920        930        940        950        960
QTYGARGKGR TQLSLLPRAL QRPSAAAPQA ENGPAAAPAV AAPAATEAPK MSNADFAKLF

LRK         10         20         30         40         50         60
MATAAETSAS EPEAESKAGP KADGEEDEVK AARTRRKVLS RAVAAATYKT MGPAWDQQEE
        70         80         90        100        110        120
GVSESDGDEY AMASSAESSP GEYEWEYDEE EEKNQLEIER LEEQLSINVY DYNCHVDLIR
       130        140        150        160        170        180
LLRLEGELTK VRMARQKMSE IFPLTEELWL EWLHDEISMA QDGLDREHVY DLFEKAVKDY
       190        200        210        220        230        240
ICPNIWLEYG QYSVGGIGQK GGLEKVRSVF ERALSSVGLH MTKGLALWEA YREFESAIVE
       250        260        270        280        290        300
AARLEKVHSL FRRQLAIPLY DMEATFAEYE EWSEDPIPES VIQNYNKALQ QLEKYKPYEE
       310        320        330        340        350        360
ALLQAEAPRL AEYQAYIDFE MKIGDPARIQ LIFERALVEN CLVPDLWIRY SQYLDRQLKV
       370        380        390        400        410        420
KDLVLSVHNR AIRNCPWTVA LWSRYLLAME RHGVDHQVIS VTFEKALNAG FIQATDYVEI
       430        440        450        460        470        480
WQAYLDYLRR RVDFKQDSSK ELEELRAAFT RALEYLKQEV EERFNESGDP SCVIMQNWAR
       490        500        510        520        530        540
IEARLCNNMQ KARELWDSIM TRGNAKYANM WLEYYNLERA HGDTQHCRKA LHRAVQCTSD
       550        560        570        580        590        600
YPEHVCEVLL TMERTEGSLE DWDIAVQKTE TRLARVNEQR MKAAEKEAAL VQQEEEKAEQ
       610        620        630        640        650        660
RKRARAEKKA LKKKKKIRGP EKRGADEDDE KEWGDDEEEQ PSKRRRVENS IPAAGETQNV
       670        680        690        700        710        720
EVAAGPAGKC AAVDVEPPSK QKEKAASLKR DMPKVLHDSS KDSITVFVSN LPYSMQEPDT
       730        740        750        760        770        780
KLRPLFEACG EVVQIRPIFS NRGDFRGYCY VEFKEEKSAL QALEMDRKSV EGRPMFVSPC
       790        800        810        820        830        840
VDKSKNPDFK VFRYSTSLEK HKLFISGLPF SCTKEELEEI CKAHGTVKDL RLVTNRAGKP
       850        860        870        880        890        900
KGLAYVEYEN ESQASQAVMK MDGMTIKENI IKVAISNPPQ RKVPEKPETR KAPGGPMLLP
       910        920        930        940        950        960
QTYGARGKGR TQLSLLPRAL QRPSAAAPQA ENGPAAAPAV AAPAATEAPK MSNADFAKLF

LRK

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

8 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q15020-2-unknown	MATAAE...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q15020-1-unknown	MATAAE...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt88888
Q15020-1-unknown	MATAAE...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt88889
Q15020-2-Acetylation	ATAAET...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q15020-2-Acetylation	ATAAET...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q15020-2-Acetylation	ATAAET...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
Q15020-2-Acetylation	ATAAET...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q15020-2-Acetylation	ATAAET...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110043
Q15020-2-Acetylation	ATAAET...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110044
Q15020-42-	AVAAAT...	42			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q15020-42-unknown	AVAAAT...	42		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177935
Q15020-42-unknown	AVAAAT...	42		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177936
Q15020-57-unknown	QQEEGV...	57		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12331
Q15020-57-unknown	QQEEGV...	57		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt139660
Q15020-57-unknown	QQEEGV...	57		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt139661
Q15020-612-unknown	KKKKKI...	612		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14518
Q15020-650-	SIPAAG...	650			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q15020-650-	SIPAAG...	650			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q15020-650-	SIPAAG...	650			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q15020-650-	SIPAAG...	650			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GPAWDQ	56	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12331
...GPAWDQ	56	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122755
...GPAWDQ	56	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122756
...EKKALK	611	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14518
...LFLRK	963	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	56	AWDQ.\|.QQEE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
GRAM_HUMAN	611	KALK.\|.KKKK	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)