Q15052: Rho guanine nucleotide exchange factor 6

General Information

Protein names	- Rho guanine nucleotide exchange factor 6 - Alpha-Pix - COOL-2 - PAK-interacting exchange factor alpha - Rac/Cdc42 guanine nucleotide exchange factor 6
Gene names	ARHGEF6
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q15052

11 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MNPEEQIVTW LISLGVLESP KKTICDPEEF LKSSLKNGVV LCKLINRLMP GSVEKFCLDP
        70         80         90        100        110        120
QTEADCINNI NDFLKGCATL QVEIFDPDDL YSGVNFSKVL STLLAVNKAT EDQLSERPCG
       130        140        150        160        170        180
RSSSLSAANT SQTNPQGAVS STVSGLQRQS KTVEMTENGS HQLIVKARFN FKQTNEDELS
       190        200        210        220        230        240
VCKGDIIYVT RVEEGGWWEG TLNGRTGWFP SNYVREIKSS ERPLSPKAVK GFETAPLTKN
       250        260        270        280        290        300
YYTVVLQNIL DTEKEYAKEL QSLLVTYLRP LQSNNNLSTV EVTSLLGNFE EVCTFQQTLC
       310        320        330        340        350        360
QALEECSKFP ENQHKVGGCL LSLMPHFKSM YLAYCANHPS AVNVLTQHSD ELEQFMENQG
       370        380        390        400        410        420
ASSPGILILT TNLSKPFMRL EKYVTLLQEL ERHMEDTHPD HQDILKAIVA FKTLMGQCQD
       430        440        450        460        470        480
LRKRKQLELQ ILSEPIQAWE GEDIKNLGNV IFMSQVMVQY GACEEKEERY LMLFSNVLIM
       490        500        510        520        530        540
LSASPRMSGF IYQGKIPIAG TVVTRLDEIE GNDCTFEITG NTVERIVVHC NNNQDFQEWL
       550        560        570        580        590        600
EQLNRLIRGP ASCSSLSKTS SSSCSAHSSF SSTGQPRGPL EPPQIIKPWS LSCLRPAPPL
       610        620        630        640        650        660
RPSAALGYKE RMSYILKESS KSPKTMKKFL HKRKTERKPS EEEYVIRKST AALEEDAQIL
       670        680        690        700        710        720
KVIEAYCTSA NFQQGHGSST RKDSIPQVLL PEEEKLIIEE TRSNGQTIME EKSLVDTVYA
       730        740        750        760        770
LKDEVRELKQ ENKRMKQCLE EELKSRRDLE KLVRRLLKQT DECIRGESSS KTSILP

Isoforms

- Isoform 2 of Rho guanine nucleotide exchange factor 6

Sequence View

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Protein Neighborhood

Domains & Features

11 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q15052-1-unknown	MNPEEQ...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q15052-155-unknown	MTENGS...	155	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt67394
Q15052-566-	AHSSFS...	566		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q15052-566-unknown	AHSSFS...	566	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt171237
Q15052-649-unknown	STAALE...	649	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt171239
Q15052-649-	STAALE...	649		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q15052-657-unknown	AQILKV...	657	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12344
Q15052-657-unknown	AQILKV...	657	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt153436
Q15052-669-unknown	SANFQQ...	669	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173680
Q15052-669-	SANFQQ...	669		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q15052-684-unknown	SIPQVL...	684	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167878
Q15052-684-	SIPQVL...	684		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q15052-684-	SIPQVL...	684		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q15052-684-	SIPQVL...	684		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q15052-684-	SIPQVL...	684		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...ALEEDA	656	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12344
...ALEEDA	656	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136859
...TSILP	776	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...TSILP	776	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt63012

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	656	EEDA.\|.AQIL	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)