Q15287: RNA-binding protein with serine-rich domain 1

General Information

Protein names	- RNA-binding protein with serine-rich domain 1 - SR-related protein LDC2
Gene names	RNPS1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q15287

5 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of RNA-binding protein with serine-rich domain 1 - Isoform 3 of RNA-binding protein with serine-rich domain 1

Sequence View

        10         20         30         40         50         60
MDLSGVKKKS LLGVKENNKK SSTRAPSPTK RKDRSDEKSK DRSKDKGATK ESSEKDRGRD
        70         80         90        100        110        120
KTRKRRSASS GSSSTRSRSS STSSSGSSTS TGSSSGSSSS SASSRSGSSS TSRSSSSSSS
       130        140        150        160        170        180
SGSPSPSRRR HDNRRRSRSK SKPPKRDEKE RKRRSPSPKP TKVHIGRLTR NVTKDHIMEI
       190        200        210        220        230        240
FSTYGKIKMI DMPVERMHPH LSKGYAYVEF ENPDEAEKAL KHMDGGQIDG QEITATAVLA
       250        260        270        280        290        300
PWPRPPPRRF SPPRRMLPPP PMWRRSPPRM RRRSRSPRRR SPVRRRSRSP GRRRHRSRSS

SNSSR         10         20         30         40         50         60
MDLSGVKKKS LLGVKENNKK SSTRAPSPTK RKDRSDEKSK DRSKDKGATK ESSEKDRGRD
        70         80         90        100        110        120
KTRKRRSASS GSSSTRSRSS STSSSGSSTS TGSSSGSSSS SASSRSGSSS TSRSSSSSSS
       130        140        150        160        170        180
SGSPSPSRRR HDNRRRSRSK SKPPKRDEKE RKRRSPSPKP TKVHIGRLTR NVTKDHIMEI
       190        200        210        220        230        240
FSTYGKIKMI DMPVERMHPH LSKGYAYVEF ENPDEAEKAL KHMDGGQIDG QEITATAVLA
       250        260        270        280        290        300
PWPRPPPRRF SPPRRMLPPP PMWRRSPPRM RRRSRSPRRR SPVRRRSRSP GRRRHRSRSS

SNSSR

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q15287-1-unknown	MDLSGV...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q15287-1-acetylation	MDLSGV...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q15287-1-acetylation	MDLSGV...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q15287-47-unknown	GATKES...	47		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10314
Q15287-47-unknown	GATKES...	47		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt137125
Q15287-47-unknown	GATKES...	47		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt137126
Q15287-206-unknown	AYVEFE...	206		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172464
Q15287-206-unknown	AYVEFE...	206		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172465
Q15287-206-	AYVEFE...	206			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q15287-206-	AYVEFE...	206			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...RSKDKG	46	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10314
...RSKDKG	46	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120011
...RSKDKG	46	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120012
...SNSSR	305	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...SNSSR	305	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt83652
...SNSSR	305	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt83651

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAA_HUMAN	46	KDKG.\|.GATK	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)