Q15942: Zyxin

General Information

Protein names	- Zyxin - Zyxin-2
Gene names	ZYX
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q15942

11 N-termini

5 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAAPRPSPAI SVSVSAPAFY APQKKFGPVV APKPKVNPFR PGDSEPPPAP GAQRAQMGRV
        70         80         90        100        110        120
GEIPPPPPED FPLPPPPLAG DGDDAEGALG GAFPPPPPPI EESFPPAPLE EEIFPSPPPP
       130        140        150        160        170        180
PEEEGGPEAP IPPPPQPREK VSSIDLEIDS LSSLLDDMTK NDPFKARVSS GYVPPPVATP
       190        200        210        220        230        240
FSSKSSTKPA AGGTAPLPPW KSPSSSQPLP QVPAPAQSQT QFHVQPQPQP KPQVQLHVQS
       250        260        270        280        290        300
QTQPVSLANT QPRGPPASSP APAPKFSPVT PKFTPVASKF SPGAPGGSGS QPNQKLGHPE
       310        320        330        340        350        360
ALSAGTGSPQ PPSFTYAQQR EKPRVQEKQH PVPPPAQNQN QVRSPGAPGP LTLKEVEELE
       370        380        390        400        410        420
QLTQQLMQDM EHPQRQNVAV NELCGRCHQP LARAQPAVRA LGQLFHIACF TCHQCAQQLQ
       430        440        450        460        470        480
GQQFYSLEGA PYCEGCYTDT LEKCNTCGEP ITDRMLRATG KAYHPHCFTC VVCARPLEGT
       490        500        510        520        530        540
SFIVDQANRP HCVPDYHKQY APRCSVCSEP IMPEPGRDET VRVVALDKNF HMKCYKCEDC
       550        560        570
GKPLSIEADD NGCFPLDGHV LCRKCHTARA QT

Isoforms

- Isoform 2 of Zyxin

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

11 N-termini - 5 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q15942-2-unknown	MAAPRP...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q15942-2-unknown	MAAPRP...	1		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000346417
Q15942-2-Acetylation	AAPRPS...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q15942-13-	SVSAPA...	13			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q15942-13-	SVSAPA...	13			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q15942-57-unknown	MGRVGE...	57		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000394158
Q15942-150-unknown	SLSSLL...	150		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1306
Q15942-150-unknown	SLSSLL...	150		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12388
Q15942-150-unknown	SLSSLL...	150			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q15942-150-	SLSSLL...	150			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q15942-150-	SLSSLL...	150			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q15942-150-	SLSSLL...	150			Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
Q15942-150-	SLSSLL...	150			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q15942-150-	SLSSLL...	150			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q15942-150-	SLSSLL...	150			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q15942-150-	SLSSLL...	150			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q15942-158-unknown	MTKNDP...	158		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000376642
Q15942-237-	HVQSQT...	237			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q15942-247-	LANTQP...	247			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q15942-247-	LANTQP...	247			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q15942-247-	LANTQP...	247			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q15942-248-	ANTQPR...	248			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q15942-248-	ANTQPR...	248			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q15942-303-	SAGTGS...	303			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...DLEIDS	149	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1306
...DLEIDS	149	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12388
...KNDPFK	164	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000400537
...SSSQPL	208	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000413467
...LEGTSF	481	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000403714
...ARAQT	572	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP1_HUMAN	149	EIDS.\|.SLSS	inferred from experiment	unknown	MEROPS	Wells JA	Agard NJ et al.:Inflammatory stimuli regulate c... (C14.001)	20173201,
GRAB_HUMAN	149	EIDS.\|.SLSS	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)