Q16531: DNA damage-binding protein 1

General Information

Protein names	- DNA damage-binding protein 1 - DDB p127 subunit - DNA damage-binding protein a - DDBa - Damage-specific DNA-binding protein 1 - HBV X-associated protein 1 - XAP-1 - UV-damaged DNA-binding factor - UV-damaged DNA-binding protein 1 - UV-DDB 1 - XPE-binding factor - XPE-BF - Xeroderma pigmentosum group E-complementing protein - XPCe
Gene names	DDB1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q16531

13 N-termini

13 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSYNYVVTAQ KPTAVNGCVT GHFTSAEDLN LLIAKNTRLE IYVVTAEGLR PVKEVGMYGK
        70         80         90        100        110        120
IAVMELFRPK GESKDLLFIL TAKYNACILE YKQSGESIDI ITRAHGNVQD RIGRPSETGI
       130        140        150        160        170        180
IGIIDPECRM IGLRLYDGLF KVIPLDRDNK ELKAFNIRLE ELHVIDVKFL YGCQAPTICF
       190        200        210        220        230        240
VYQDPQGRHV KTYEVSLREK EFNKGPWKQE NVEAEASMVI AVPEPFGGAI IIGQESITYH
       250        260        270        280        290        300
NGDKYLAIAP PIIKQSTIVC HNRVDPNGSR YLLGDMEGRL FMLLLEKEEQ MDGTVTLKDL
       310        320        330        340        350        360
RVELLGETSI AECLTYLDNG VVFVGSRLGD SQLVKLNVDS NEQGSYVVAM ETFTNLGPIV
       370        380        390        400        410        420
DMCVVDLERQ GQGQLVTCSG AFKEGSLRII RNGIGIHEHA SIDLPGIKGL WPLRSDPNRE
       430        440        450        460        470        480
TDDTLVLSFV GQTRVLMLNG EEVEETELMG FVDDQQTFFC GNVAHQQLIQ ITSASVRLVS
       490        500        510        520        530        540
QEPKALVSEW KEPQAKNISV ASCNSSQVVV AVGRALYYLQ IHPQELRQIS HTEMEHEVAC
       550        560        570        580        590        600
LDITPLGDSN GLSPLCAIGL WTDISARILK LPSFELLHKE MLGGEIIPRS ILMTTFESSH
       610        620        630        640        650        660
YLLCALGDGA LFYFGLNIET GLLSDRKKVT LGTQPTVLRT FRSLSTTNVF ACSDRPTVIY
       670        680        690        700        710        720
SSNHKLVFSN VNLKEVNYMC PLNSDGYPDS LALANNSTLT IGTIDEIQKL HIRTVPLYES
       730        740        750        760        770        780
PRKICYQEVS QCFGVLSSRI EVQDTSGGTT ALRPSASTQA LSSSVSSSKL FSSSTAPHET
       790        800        810        820        830        840
SFGEEVEVHN LLIIDQHTFE VLHAHQFLQN EYALSLVSCK LGKDPNTYFI VGTAMVYPEE
       850        860        870        880        890        900
AEPKQGRIVV FQYSDGKLQT VAEKEVKGAV YSMVEFNGKL LASINSTVRL YEWTTEKELR
       910        920        930        940        950        960
TECNHYNNIM ALYLKTKGDF ILVGDLMRSV LLLAYKPMEG NFEEIARDFN PNWMSAVEIL
       970        980        990       1000       1010       1020
DDDNFLGAEN AFNLFVCQKD SAATTDEERQ HLQEVGLFHL GEFVNVFCHG SLVMQNLGET
      1030       1040       1050       1060       1070       1080
STPTQGSVLF GTVNGMIGLV TSLSESWYNL LLDMQNRLNK VIKSVGKIEH SFWRSFHTER
      1090       1100       1110       1120       1130       1140
KTEPATGFID GDLIESFLDI SRPKMQEVVA NLQYDDGSGM KREATADDLI KVVEELTRIH

Isoforms

- Isoform 2 of DNA damage-binding protein 1

Sequence View

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Protein Neighborhood

Domains & Features

13 N-termini - 13 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name
Q16531-2-unknown	MSYNYV...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q16531-2-Acetylation	SYNYVV...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q16531-57-unknown	MYGKIA...	57		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000445554
Q16531-57-unknown	MYGKIA...	57		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000441825
Q16531-118-unknown	TGIIGI...	118		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17994
Q16531-118-	TGIIGI...	118			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
Q16531-120-unknown	IIGIID...	120		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4117
Q16531-120-unknown	IIGIID...	120		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17995
Q16531-218-unknown	MVIAVP...	218		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000446044
Q16531-350-unknown	METFTN...	350		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000437713
Q16531-437-unknown	MLNGEE...	437		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000442732
Q16531-534-unknown	MEHEVA...	534		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000444650
Q16531-835-unknown	MVYPEE...	835		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000439787
Q16531-954-unknown	MSAVEI...	954		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000441522
Q16531-1014-unknown	MQNLGE...	1014		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000399813

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...HGNVQD	109	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000440660
...GRPSET	117	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17994
...PSETGI	119	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4117
...PSETGI	119	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17995
...VIPLDR	146	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000444105
...SMVIAV	221	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000445554
...CVVDLE	367	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000442660
...EMLGGE	584	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000445563
...NIETGL	621	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000437713
...NLKEVN	676	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000442732
...QHTFEV	800	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000444650
...RIVVFQ	851	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000445844
...VNGMIG	1037	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000439787
...LTRIH	1140	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1A_HUMAN	117	PSET.\|.TGII	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATB_HUMAN	119	ETGI.\|.IIGI	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1A_HUMAN	119	ETGI.\|.IIGI	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)