Q16643: Drebrin

General Information

Protein names	- Drebrin - Developmentally-regulated brain protein
Gene names	DBN1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q16643

17 N-termini

5 C-termini

4 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Drebrin - Isoform 3 of Drebrin

Sequence View

        10         20         30         40         50         60
MAGVSFSGHR LELLAAYEEV IREESAADWA LYTYEDGSDD LKLAASGEGG LQELSGHFEN
        70         80         90        100        110        120
QKVMYGFCSV KDSQAALPKY VLINWVGEDV PDARKCACAS HVAKVAEFFQ GVDVIVNASS
       130        140        150        160        170        180
VEDIDAGAIG QRLSNGLARL SSPVLHRLRL REDENAEPVG TTYQKTDAAV EMKRINREQF
       190        200        210        220        230        240
WEQAKKEEEL RKEEERKKAL DERLRFEQER MEQERQEQEE RERRYREREQ QIEEHRRKQQ
       250        260        270        280        290        300
TLEAEEAKRR LKEQSIFGDH RDEEEETHMK KSESEVEEAA AIIAQRPDNP REFFKQQERV
       310        320        330        340        350        360
ASASAGSCDV PSPFNHRPGS HLDSHRRMAP TPIPTRSPSD SSTASTPVAE QIERALDEVT
       370        380        390        400        410        420
SSQPPPLPPP PPPAQETQEP SPILDSEETR AAAPQAWAGP MEEPPQAQAP PRGPGSPAED
       430        440        450        460        470        480
LMFMESAEQA VLAAPVEPAT ADATEIHDAA DTIETDTATA DTTVANNVPP AATSLIDLWP
       490        500        510        520        530        540
GNGEGASTLQ GEPRAPTPPS GTEVTLAEVP LLDEVAPEPL LPAGEGCATL LNFDELPEPP
       550        560        570        580        590        600
ATFCDPEEVE GESLAAPQTP TLPSALEELE QEQEPEPHLL TNGETTQKEG TQASEGYFSQ
       610        620        630        640
SQEEEFAQSE ELCAKAPPPV FYNKPPEIDI TCWDADPVPE EEEGFEGGD         10         20         30         40         50         60
MAGVSFSGHR LELLAAYEEV IREESAADWA LYTYEDGSDD LKLAASGEGG LQELSGHFEN
        70         80         90        100        110        120
QKVMYGFCSV KDSQAALPKY VLINWVGEDV PDARKCACAS HVAKVAEFFQ GVDVIVNASS
       130        140        150        160        170        180
VEDIDAGAIG QRLSNGLARL SSPVLHRLRL REDENAEPVG TTYQKTDAAV EMKRINREQF
       190        200        210        220        230        240
WEQAKKEEEL RKEEERKKAL DERLRFEQER MEQERQEQEE RERRYREREQ QIEEHRRKQQ
       250        260        270        280        290        300
TLEAEEAKRR LKEQSIFGDH RDEEEETHMK KSESEVEEAA AIIAQRPDNP REFFKQQERV
       310        320        330        340        350        360
ASASAGSCDV PSPFNHRPGS HLDSHRRMAP TPIPTRSPSD SSTASTPVAE QIERALDEVT
       370        380        390        400        410        420
SSQPPPLPPP PPPAQETQEP SPILDSEETR AAAPQAWAGP MEEPPQAQAP PRGPGSPAED
       430        440        450        460        470        480
LMFMESAEQA VLAAPVEPAT ADATEIHDAA DTIETDTATA DTTVANNVPP AATSLIDLWP
       490        500        510        520        530        540
GNGEGASTLQ GEPRAPTPPS GTEVTLAEVP LLDEVAPEPL LPAGEGCATL LNFDELPEPP
       550        560        570        580        590        600
ATFCDPEEVE GESLAAPQTP TLPSALEELE QEQEPEPHLL TNGETTQKEG TQASEGYFSQ
       610        620        630        640
SQEEEFAQSE ELCAKAPPPV FYNKPPEIDI TCWDADPVPE EEEGFEGGD

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

17 N-termini - 5 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q16643-2-unknown	MAGVSF...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q16643-1-unknown	MAGVSF...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt73243
Q16643-2-Acetylation	AGVSFS...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q16643-2-Acetylation	AGVSFS...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110626
Q16643-90-unknown	VPDARK...	90		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2722
Q16643-90-unknown	VPDARK...	90		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt141832
Q16643-90-unknown	VPDARK...	90		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt141952
Q16643-126-unknown	AGAIGQ...	126		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2725
Q16643-126-unknown	AGAIGQ...	126		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt143741
Q16643-126-unknown	AGAIGQ...	126		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt143811
Q16643-168-unknown	AAVEMK...	168		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2249
Q16643-168-unknown	AAVEMK...	168		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145468
Q16643-168-unknown	AAVEMK...	168		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145540
Q16643-328-unknown	MAPTPI...	328			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q16643-328-unknown	MAPTPI...	328		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161476
Q16643-328-unknown	MAPTPI...	328		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161475
Q16643-328-	MAPTPI...	328			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q16643-341-	SSTAST...	341			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q16643-341-unknown	SSTAST...	341		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173984
Q16643-341-unknown	SSTAST...	341		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173983
Q16643-362-unknown	SQPPPL...	362		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167456
Q16643-362-unknown	SQPPPL...	362		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167455
Q16643-362-	SQPPPL...	362			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q16643-362-	SQPPPL...	362			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q16643-362-	SQPPPL...	362			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q16643-478-unknown	LWPGNG...	478		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165619
Q16643-478-unknown	LWPGNG...	478		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165618
Q16643-478-	LWPGNG...	478			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q16643-483-	GEGAST...	483			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q16643-483-unknown	GEGAST...	483		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173981
Q16643-483-unknown	GEGAST...	483		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173980
Q16643-630-unknown	ITCWDA...	630		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2728
Q16643-630-unknown	ITCWDA...	630		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt155098
Q16643-630-unknown	ITCWDA...	630		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt155617

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...WVGEDV	89	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2722
...WVGEDV	89	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125011
...WVGEDV	89	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125133
...VEDIDA	125	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2725
...VEDIDA	125	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126984
...VEDIDA	125	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127054
...YQKTDA	167	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2249
...YQKTDA	167	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128763
...YQKTDA	167	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128838
...PPEIDI	629	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2728
...PPEIDI	629	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt138525
...PPEIDI	629	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt139059
...FEGGD	649	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...FEGGD	649	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt68860
...FEGGD	649	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt68861

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP6_HUMAN	89	GEDV.\|.VPDA	inferred from experiment	unknown	MEROPS	Leblanc AC	Klaiman G et al.:Targets of caspase-6 activity i... (C14.005)	18487604,
CASP6_HUMAN	125	DIDA.\|.AGAI	inferred from experiment	unknown	MEROPS	Leblanc AC	Klaiman G et al.:Targets of caspase-6 activity i... (C14.005)	18487604,
CASP3_HUMAN	167	KTDA.\|.AAVE	inferred from experiment	unknown	MEROPS		Merops CASP3_HUMAN -> DREB_HUMAN @167
CASP6_HUMAN	629	EIDI.\|.ITCW	inferred from experiment	unknown	MEROPS	Leblanc AC	Klaiman G et al.:Targets of caspase-6 activity i... (C14.005)	18487604,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)