Q2NL82: Pre-rRNA-processing protein TSR1 homolog

General Information

Protein names	- Pre-rRNA-processing protein TSR1 homolog
Gene names	TSR1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q2NL82

4 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAAHRPGPLK QQNKAHKGGR HRGRGSAQRD GKGRLALKTL SKKVRKELSR VDQRHRASQL
        70         80         90        100        110        120
RKQKKEAVLA EKRQLGGKDG PPHQVLVVPL HSRISLPEAM QLLQDRDTGT VHLNELGNTQ
       130        140        150        160        170        180
NFMLLCPRLK HRWFFTSARP GDLHVVLDMA KVADTILFLL DPLEGWDSTG DYCLSCLFAQ
       190        200        210        220        230        240
GLPTYTLAVQ GISGLPLKKQ IDTRKKLSKA VEKRFPHDKL LLLDTQQEAG MLLRQLANQK
       250        260        270        280        290        300
QQHLAFRDRR AYLFAHAVDF VPSEENNLVG TLKISGYVRG QTLNVNRLLH IVGYGDFQMK
       310        320        330        340        350        360
QIDAPGDPFP LNPRGIKPQK DPDMAMEICA TDAVDDMEEG LKVLMKADPG RQESLQAEVI
       370        380        390        400        410        420
PDPMEGEQTW PTEEELSEAK DFLKESSKVV KKVPKGTSSY QAEWILDGGS QSGGEGDEYE
       430        440        450        460        470        480
YDDMEHEDFM EEESQDESSE EEEEYETMTI GESVHDDLYD KKVDEEAEAK MLEKYKQERL
       490        500        510        520        530        540
EEMFPDEVDT PRDVAARIRF QKYRGLKSFR TSPWDPKENL PQDYARIFQF QNFTNTRKSI
       550        560        570        580        590        600
FKEVEEKEVE GAEVGWYVTL HVSEVPVSVV ECFRQGTPLI AFSLLPHEQK MSVLNMVVRR
       610        620        630        640        650        660
DPGNTEPVKA KEELIFHCGF RRFRASPLFS QHTAADKHKL QRFLTADMAL VATVYAPITF
       670        680        690        700        710        720
PPASVLLFKQ KSNGMHSLIA TGHLMSVDPD RMVIKRVVLS GHPFKIFTKM AVVRYMFFNR
       730        740        750        760        770        780
EDVLWFKPVE LRTKWGRRGH IKEPLGTHGH MKCSFDGKLK SQDTVLMNLY KRVFPKWTYD
       790        800
PYVPEPVPWL KSEISSTVPQ GGME

Isoforms

Sequence View

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q2NL82-1-unknown	MAAHRP...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q2NL82-38-unknown	KTLSKK...	38	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14546
Q2NL82-333-	AVDDME...	333		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q2NL82-333-	AVDDME...	333		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q2NL82-333-	AVDDME...	333		Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
Q2NL82-333-	AVDDME...	333		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q2NL82-333-	AVDDME...	333		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q2NL82-333-	AVDDME...	333		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q2NL82-333-	AVDDME...	333		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q2NL82-333-unknown	AVDDME...	333		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...GRLALK	37	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14546
	...QGGME	804	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	37	LALK.\|.KTLS	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)