Q3KQU3: MAP7 domain-containing protein 1

General Information

Protein names	- MAP7 domain-containing protein 1 - Arginine/proline-rich coiled-coil domain-containing protein 1 - Proline/arginine-rich coiled-coil domain-containing protein 1
Gene names	MAP7D1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q3KQU3

4 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of MAP7 domain-containing protein 1 - Isoform 3 of MAP7 domain-containing protein 1 - Isoform 4 of MAP7 domain-containing protein 1

Sequence View

        10         20         30         40         50         60
MESGPRAELG AGAPPAVVAR TPPEPRPSPE GDPSPPPPPM SALVPDTPPD TPPAMKNATS
        70         80         90        100        110        120
SKQLPLEPES PSGQVGPRPA PPQEESPSSE AKSRGPTPPA MGPRDARPPR RSSQPSPTAV
       130        140        150        160        170        180
PASDSPPTKQ EVKKAGERHK LAKERREERA KYLAAKKAVW LEKEEKAKAL REKQLQERRR
       190        200        210        220        230        240
RLEEQRLKAE QRRAALEERQ RQKLEKNKER YEAAIQRSVK KTWAEIRQQR WSWAGALHHS
       250        260        270        280        290        300
SPGHKTSGSR CSVSAVNLPK HVDSIINKRL SKSSATLWNS PSRNRSLQLS AWESSIVDRL
       310        320        330        340        350        360
MTPTLSFLAR SRSAVTLPRN GRDQGRGCDP GRGPTWGRAG ASLARGPQPD RTHPSAAVPV
       370        380        390        400        410        420
CPRSASASPL TPCSVTRSVH RCAPAGERGE RRKPNAGGSP APVRRRPEAS PVQKKEKKDK
       430        440        450        460        470        480
ERENEKEKSA LARERSLKKR QSLPASPRAR LSASTASELS PKSKARPSSP STSWHRPASP
       490        500        510        520        530        540
CPSPGPGHTL PPKPPSPRGT TASPKGRVRR KEEAKESPSA AGPEDKSQSK RRASNEKESA
       550        560        570        580        590        600
APASPAPSPA PSPTPAPPQK EQPPAETPTD AAVLTSPPAP APPVTPSKPM AGTTDREEAT
       610        620        630        640        650        660
RLLAEKRRQA REQREREEQE RRLQAERDKR MREEQLAREA EARAEREAEA RRREEQEARE
       670        680        690        700        710        720
KAQAEQEEQE RLQKQKEEAE ARSREEAERQ RLEREKHFQQ QEQERQERRK RLEEIMKRTR
       730        740        750        760        770        780
KSEVSETKQK QDSKEANANG SSPEPVKAVE ARSPGLQKEA VQKEEPIPQE PQWSLPSKEL
       790        800        810        820        830        840
PASLVNGLQP LPAHQENGFS TNGPSGDKSL SRTPETLLPF AEAEAFLKKA VVQSPQVTEV

L         10         20         30         40         50         60
MESGPRAELG AGAPPAVVAR TPPEPRPSPE GDPSPPPPPM SALVPDTPPD TPPAMKNATS
        70         80         90        100        110        120
SKQLPLEPES PSGQVGPRPA PPQEESPSSE AKSRGPTPPA MGPRDARPPR RSSQPSPTAV
       130        140        150        160        170        180
PASDSPPTKQ EVKKAGERHK LAKERREERA KYLAAKKAVW LEKEEKAKAL REKQLQERRR
       190        200        210        220        230        240
RLEEQRLKAE QRRAALEERQ RQKLEKNKER YEAAIQRSVK KTWAEIRQQR WSWAGALHHS
       250        260        270        280        290        300
SPGHKTSGSR CSVSAVNLPK HVDSIINKRL SKSSATLWNS PSRNRSLQLS AWESSIVDRL
       310        320        330        340        350        360
MTPTLSFLAR SRSAVTLPRN GRDQGRGCDP GRGPTWGRAG ASLARGPQPD RTHPSAAVPV
       370        380        390        400        410        420
CPRSASASPL TPCSVTRSVH RCAPAGERGE RRKPNAGGSP APVRRRPEAS PVQKKEKKDK
       430        440        450        460        470        480
ERENEKEKSA LARERSLKKR QSLPASPRAR LSASTASELS PKSKARPSSP STSWHRPASP
       490        500        510        520        530        540
CPSPGPGHTL PPKPPSPRGT TASPKGRVRR KEEAKESPSA AGPEDKSQSK RRASNEKESA
       550        560        570        580        590        600
APASPAPSPA PSPTPAPPQK EQPPAETPTD AAVLTSPPAP APPVTPSKPM AGTTDREEAT
       610        620        630        640        650        660
RLLAEKRRQA REQREREEQE RRLQAERDKR MREEQLAREA EARAEREAEA RRREEQEARE
       670        680        690        700        710        720
KAQAEQEEQE RLQKQKEEAE ARSREEAERQ RLEREKHFQQ QEQERQERRK RLEEIMKRTR
       730        740        750        760        770        780
KSEVSETKQK QDSKEANANG SSPEPVKAVE ARSPGLQKEA VQKEEPIPQE PQWSLPSKEL
       790        800        810        820        830        840
PASLVNGLQP LPAHQENGFS TNGPSGDKSL SRTPETLLPF AEAEAFLKKA VVQSPQVTEV

L         10         20         30         40         50         60
MESGPRAELG AGAPPAVVAR TPPEPRPSPE GDPSPPPPPM SALVPDTPPD TPPAMKNATS
        70         80         90        100        110        120
SKQLPLEPES PSGQVGPRPA PPQEESPSSE AKSRGPTPPA MGPRDARPPR RSSQPSPTAV
       130        140        150        160        170        180
PASDSPPTKQ EVKKAGERHK LAKERREERA KYLAAKKAVW LEKEEKAKAL REKQLQERRR
       190        200        210        220        230        240
RLEEQRLKAE QRRAALEERQ RQKLEKNKER YEAAIQRSVK KTWAEIRQQR WSWAGALHHS
       250        260        270        280        290        300
SPGHKTSGSR CSVSAVNLPK HVDSIINKRL SKSSATLWNS PSRNRSLQLS AWESSIVDRL
       310        320        330        340        350        360
MTPTLSFLAR SRSAVTLPRN GRDQGRGCDP GRGPTWGRAG ASLARGPQPD RTHPSAAVPV
       370        380        390        400        410        420
CPRSASASPL TPCSVTRSVH RCAPAGERGE RRKPNAGGSP APVRRRPEAS PVQKKEKKDK
       430        440        450        460        470        480
ERENEKEKSA LARERSLKKR QSLPASPRAR LSASTASELS PKSKARPSSP STSWHRPASP
       490        500        510        520        530        540
CPSPGPGHTL PPKPPSPRGT TASPKGRVRR KEEAKESPSA AGPEDKSQSK RRASNEKESA
       550        560        570        580        590        600
APASPAPSPA PSPTPAPPQK EQPPAETPTD AAVLTSPPAP APPVTPSKPM AGTTDREEAT
       610        620        630        640        650        660
RLLAEKRRQA REQREREEQE RRLQAERDKR MREEQLAREA EARAEREAEA RRREEQEARE
       670        680        690        700        710        720
KAQAEQEEQE RLQKQKEEAE ARSREEAERQ RLEREKHFQQ QEQERQERRK RLEEIMKRTR
       730        740        750        760        770        780
KSEVSETKQK QDSKEANANG SSPEPVKAVE ARSPGLQKEA VQKEEPIPQE PQWSLPSKEL
       790        800        810        820        830        840
PASLVNGLQP LPAHQENGFS TNGPSGDKSL SRTPETLLPF AEAEAFLKKA VVQSPQVTEV

L

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(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q3KQU3-1-unknown	MESGPR...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q3KQU3-1-unknown	MESGPR...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt80219
Q3KQU3-1-unknown	MESGPR...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt80221
Q3KQU3-452-unknown	SASTAS...	452	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14551
Q3KQU3-452-unknown	SASTAS...	452	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152257
Q3KQU3-452-unknown	SASTAS...	452	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152342
Q3KQU3-571-	AAVLTS...	571		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q3KQU3-571-	AAVLTS...	571		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q3KQU3-571-	AAVLTS...	571		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q3KQU3-571-	AAVLTS...	571		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q3KQU3-571-unknown	AAVLTS...	571	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt174108
Q3KQU3-571-unknown	AAVLTS...	571	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt174107

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PRARLS	451	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14551
...PRARLS	451	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135667
...PRARLS	451	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135753
...VTEVL	841	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...VTEVL	841	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt75838
...VTEVL	841	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt75837
...VTEVL	841	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt75839

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	451	ARLS.\|.SAST	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)