Q5JTH9: RRP12-like protein

General Information

Protein names	- RRP12-like protein
Gene names	RRP12
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q5JTH9

12 N-termini

4 C-termini

3 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of RRP12-like protein - Isoform 3 of RRP12-like protein

Sequence View

        10         20         30         40         50         60
MGRSGKLPSG VSAKLKRWKK GHSSDSNPAI CRHRQAARSR FFSRPSGRSD LTVDAVKLHN
        70         80         90        100        110        120
ELQSGSLRLG KSEAPETPME EEAELVLTEK SSGTFLSGLS DCTNVTFSKV QRFWESNSAA
       130        140        150        160        170        180
HKEICAVLAA VTEVIRSQGG KETETEYFAA LMTTMEAVES PESLAAVAYL LNLVLKRVPS
       190        200        210        220        230        240
PVLIKKFSDT SKAFMDIMSA QASSGSTSVL RWVLSCLATL LRKQDLEAWG YPVTLQVYHG
       250        260        270        280        290        300
LLSFTVHPKP KIRKAAQHGV CSVLKGSEFM FEKAPAHHPA AISTAKFCIQ EIEKSGGSKE
       310        320        330        340        350        360
ATTTLHMLTL LKDLLPCFPE GLVKSCSETL LRVMTLSHVL VTACAMQAFH SLFHARPGLS
       370        380        390        400        410        420
TLSAELNAQI ITALYDYVPS ENDLQPLLAW LKVMEKAHIN LVRLQWDLGL GHLPRFFGTA
       430        440        450        460        470        480
VTCLLSPHSQ VLTAATQSLK EILKECVAPH MADIGSVTSS ASGPAQSVAK MFRAVEEGLT
       490        500        510        520        530        540
YKFHAAWSSV LQLLCVFFEA CGRQAHPVMR KCLQSLCDLR LSPHFPHTAA LDQAVGAAVT
       550        560        570        580        590        600
SMGPEVVLQA VPLEIDGSEE TLDFPRSWLL PVIRDHVQET RLGFFTTYFL PLANTLKSKA
       610        620        630        640        650        660
MDLAQAGSTV ESKIYDTLQW QMWTLLPGFC TRPTDVAISF KGLARTLGMA ISERPDLRVT
       670        680        690        700        710        720
VCQALRTLIT KGCQAEADRA EVSRFAKNFL PILFNLYGQP VAAGDTPAPR RAVLETIRTY
       730        740        750        760        770        780
LTITDTQLVN SLLEKASEKV LDPASSDFTR LSVLDLVVAL APCADEAAIS KLYSTIRPYL
       790        800        810        820        830        840
ESKAHGVQKK AYRVLEEVCA SPQGPGALFV QSHLEDLKKT LLDSLRSTSS PAKRPRLKCL
       850        860        870        880        890        900
LHIVRKLSAE HKEFITALIP EVILCTKEVS VGARKNAFAL LVEMGHAFLR FGSNQEEALQ
       910        920        930        940        950        960
CYLVLIYPGL VGAVTMVSCS ILALTHLLFE FKGLMGTSTV EQLLENVCLL LASRTRDVVK
       970        980        990       1000       1010       1020
SALGFIKVAV TVMDVAHLAK HVQLVMEAIG KLSDDMRRHF RMKLRNLFTK FIRKFGFELV
      1030       1040       1050       1060       1070       1080
KRLLPEEYHR VLVNIRKAEA RAKRHRALSQ AAVEEEEEEE EEEEPAQGKG DSIEEILADS
      1090       1100       1110       1120       1130       1140
EDEEDNEEEE RSRGKEQRKL ARQRSRAWLK EGGGDEPLNF LDPKVAQRVL ATQPGPGRGR
      1150       1160       1170       1180       1190       1200
KKDHGFKVSA DGRLIIREEA DGNKMEEEEG AKGEDEEMAD PMEDVIIRNK KHQKLKHQKE
      1210       1220       1230       1240       1250       1260
AEEEELEIPP QYQAGGSGIH RPVAKKAMPG AEYKAKKAKG DVKKKGRPDP YAYIPLNRSK
      1270       1280       1290
LNRRKKMKLQ GQFKGLVKAA RRGSQVGHKN RRKDRRP         10         20         30         40         50         60
MGRSGKLPSG VSAKLKRWKK GHSSDSNPAI CRHRQAARSR FFSRPSGRSD LTVDAVKLHN
        70         80         90        100        110        120
ELQSGSLRLG KSEAPETPME EEAELVLTEK SSGTFLSGLS DCTNVTFSKV QRFWESNSAA
       130        140        150        160        170        180
HKEICAVLAA VTEVIRSQGG KETETEYFAA LMTTMEAVES PESLAAVAYL LNLVLKRVPS
       190        200        210        220        230        240
PVLIKKFSDT SKAFMDIMSA QASSGSTSVL RWVLSCLATL LRKQDLEAWG YPVTLQVYHG
       250        260        270        280        290        300
LLSFTVHPKP KIRKAAQHGV CSVLKGSEFM FEKAPAHHPA AISTAKFCIQ EIEKSGGSKE
       310        320        330        340        350        360
ATTTLHMLTL LKDLLPCFPE GLVKSCSETL LRVMTLSHVL VTACAMQAFH SLFHARPGLS
       370        380        390        400        410        420
TLSAELNAQI ITALYDYVPS ENDLQPLLAW LKVMEKAHIN LVRLQWDLGL GHLPRFFGTA
       430        440        450        460        470        480
VTCLLSPHSQ VLTAATQSLK EILKECVAPH MADIGSVTSS ASGPAQSVAK MFRAVEEGLT
       490        500        510        520        530        540
YKFHAAWSSV LQLLCVFFEA CGRQAHPVMR KCLQSLCDLR LSPHFPHTAA LDQAVGAAVT
       550        560        570        580        590        600
SMGPEVVLQA VPLEIDGSEE TLDFPRSWLL PVIRDHVQET RLGFFTTYFL PLANTLKSKA
       610        620        630        640        650        660
MDLAQAGSTV ESKIYDTLQW QMWTLLPGFC TRPTDVAISF KGLARTLGMA ISERPDLRVT
       670        680        690        700        710        720
VCQALRTLIT KGCQAEADRA EVSRFAKNFL PILFNLYGQP VAAGDTPAPR RAVLETIRTY
       730        740        750        760        770        780
LTITDTQLVN SLLEKASEKV LDPASSDFTR LSVLDLVVAL APCADEAAIS KLYSTIRPYL
       790        800        810        820        830        840
ESKAHGVQKK AYRVLEEVCA SPQGPGALFV QSHLEDLKKT LLDSLRSTSS PAKRPRLKCL
       850        860        870        880        890        900
LHIVRKLSAE HKEFITALIP EVILCTKEVS VGARKNAFAL LVEMGHAFLR FGSNQEEALQ
       910        920        930        940        950        960
CYLVLIYPGL VGAVTMVSCS ILALTHLLFE FKGLMGTSTV EQLLENVCLL LASRTRDVVK
       970        980        990       1000       1010       1020
SALGFIKVAV TVMDVAHLAK HVQLVMEAIG KLSDDMRRHF RMKLRNLFTK FIRKFGFELV
      1030       1040       1050       1060       1070       1080
KRLLPEEYHR VLVNIRKAEA RAKRHRALSQ AAVEEEEEEE EEEEPAQGKG DSIEEILADS
      1090       1100       1110       1120       1130       1140
EDEEDNEEEE RSRGKEQRKL ARQRSRAWLK EGGGDEPLNF LDPKVAQRVL ATQPGPGRGR
      1150       1160       1170       1180       1190       1200
KKDHGFKVSA DGRLIIREEA DGNKMEEEEG AKGEDEEMAD PMEDVIIRNK KHQKLKHQKE
      1210       1220       1230       1240       1250       1260
AEEEELEIPP QYQAGGSGIH RPVAKKAMPG AEYKAKKAKG DVKKKGRPDP YAYIPLNRSK
      1270       1280       1290
LNRRKKMKLQ GQFKGLVKAA RRGSQVGHKN RRKDRRP

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

12 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q5JTH9-1-unknown	MGRSGK...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q5JTH9-1-unknown	MGRSGK...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt88252
Q5JTH9-1-unknown	MGRSGK...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt88253
Q5JTH9-55-unknown	AVKLHN...	55	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173220
Q5JTH9-55-unknown	AVKLHN...	55	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173221
Q5JTH9-55-	AVKLHN...	55		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q5JTH9-55-	AVKLHN...	55		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q5JTH9-55-	AVKLHN...	55		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q5JTH9-83-unknown	AELVLT...	83	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12475
Q5JTH9-83-unknown	AELVLT...	83	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt141486
Q5JTH9-83-unknown	AELVLT...	83	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt141487
Q5JTH9-550-	AVPLEI...	550		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q5JTH9-550-	AVPLEI...	550		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q5JTH9-550-unknown	AVPLEI...	550	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176213
Q5JTH9-550-unknown	AVPLEI...	550	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176212
Q5JTH9-557-	GSEETL...	557		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q5JTH9-557-unknown	GSEETL...	557	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170505
Q5JTH9-557-unknown	GSEETL...	557	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170504
Q5JTH9-1072-unknown	SIEEIL...	1072	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12478
Q5JTH9-1072-unknown	SIEEIL...	1072	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt157091
Q5JTH9-1072-unknown	SIEEIL...	1072	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt157177
Q5JTH9-1162-	GNKMEE...	1162		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q5JTH9-1162-	GNKMEE...	1162		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q5JTH9-1162-unknown	GNKMEE...	1162	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170502
Q5JTH9-1162-unknown	GNKMEE...	1162	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170501
Q5JTH9-1183-unknown	EDVIIR...	1183	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12481
Q5JTH9-1183-unknown	EDVIIR...	1183	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt157334
Q5JTH9-1183-unknown	EDVIIR...	1183	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt157454

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PMEEEA	82	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12475
...PMEEEA	82	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124662
...PMEEEA	82	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124663
...QGKGDS	1071	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12478
...QGKGDS	1071	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140589
...QGKGDS	1071	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140678
...MADPME	1182	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12481
...MADPME	1182	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140833
...MADPME	1182	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140952
...KDRRP	1297	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...KDRRP	1297	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt83870
...KDRRP	1297	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt83871

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	82	EEEA.\|.AELV	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAB_HUMAN	1071	KGDS.\|.SIEE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAB_HUMAN	1182	DPME.\|.EDVI	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)