Q5SW79: Centrosomal protein of 170 kDa
Protein names | - Centrosomal protein of 170 kDa - Cep170 - KARP-1-binding protein - KARP1-binding protein |
---|---|
Gene names | CEP170 |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | Q5SW79 |
18
N-termini
5
C-termini
4
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MSLTSWFLVS SGGTRHRLPR EMIFVGRDDC ELMLQSRSVD KQHAVINYDA STDEHLVKDL
70 80 90 100 110 120
GSLNGTFVND VRIPEQTYIT LKLEDKLRFG YDTNLFTVVQ GEMRVPEEAL KHEKFTIQLQ
130 140 150 160 170 180
LSQKSSESEL SKSASAKSID SKVADAATEV QHKTTEALKS EEKAMDISAM PRGTPLYGQP
190 200 210 220 230 240
SWWGDDEVDE KRAFKTNGKP EEKNHEAGTS GCGIDAKQVE EQSAAANEEV LFPFCREPSY
250 260 270 280 290 300
FEIPTKEFQQ PSQITESTIH EIPTKDTPSS HITGAGHASF TIEFDDSTPG KVTIRDHVTK
310 320 330 340 350 360
FTSDQRHKSK KSSPGTQDLL GIQTGMMAPE NKVADWLAQN NPPQMLWERT EEDSKSIKSD
370 380 390 400 410 420
VPVYLKRLKG NKHDDGTQSD SENAGAHRRC SKRATLEEHL RRHHSEHKKL QKVQATEKHQ
430 440 450 460 470 480
DQAVTSSAHH RGGHGVPHGK LLKQKSEEPS VSIPFLQTAL LRSSGSLGHR PSQEMDKMLK
490 500 510 520 530 540
NQATSATSEK DNDDDQSDKG TYTIELENPN SEEVEARKMI DKVFGVDDNQ DYNRPVINEK
550 560 570 580 590 600
HKDLIKDWAL SSAAAVMEER KPLTTSGFHH SEEGTSSSGS KRWVSQWASL AANHTRHDQE
610 620 630 640 650 660
ERIMEFSAPL PLENETEISE SGMTVRSTGS ATSLASQGER RRRTLPQLPN EEKSLESHRA
670 680 690 700 710 720
KVVTQRSEIG EKQDTELQEK ETPTQVYQKD KQDADRPLSK MNRAVNGETL KTGGDNKTLL
730 740 750 760 770 780
HLGSSAPGKE KSETDKETSL VKQTLAKLQQ QEQREEAQWT PTKLSSKNVS GQTDKCREET
790 800 810 820 830 840
FKQESQPPEK NSGHSTSKGD RVAQSESKRR KAEEILKSQT PKGGDKKESS KSLVRQGSFT
850 860 870 880 890 900
IEKPSPNIPI ELIPHINKQT SSTPSSLALT SASRIRERSE SLDPDSSMDT TLILKDTEAV
910 920 930 940 950 960
MAFLEAKLRE DNKTDEGPDT PSYNRDNSIS PESDVDTAST ISLVTGETER KSTQKRKSFT
970 980 990 1000 1010 1020
SLYKDRCSTG SPSKDVTKSS SSGAREKMEK KTKSRSTDVG SRADGRKFVQ SSGRIRQPSV
1030 1040 1050 1060 1070 1080
DLTDDDQTSS VPHSAISDIM SSDQETYSCK PHGRTPLTSA DEHVHSKLEG SKVTKSKTSP
1090 1100 1110 1120 1130 1140
VVSGSSSKST TLPRPRPTRT SLLRRARLGE ASDSELADAD KASVASEVST TSSTSKPPTG
1150 1160 1170 1180 1190 1200
RRNISRIDLL AQPRRTRLGS LSARSDSEAT ISRSSASSRT AEAIIRSGAR LVPSDKFSPR
1210 1220 1230 1240 1250 1260
IRANSISRLS DSKVKSMTSA HGSASVNSRW RRFPTDYAST SEDEFGSNRN SPKHTRLRTS
1270 1280 1290 1300 1310 1320
PALKTTRLQS AGSAMPTSSS FKHRIKEQED YIRDWTAHRE EIARISQDLA LIAREINDVA
1330 1340 1350 1360 1370 1380
GEIDSVTSSG TAPSTTVSTA ATTPGSAIDT REELVDRVFD ESLNFRKIPP LVHSKTPEGN
1390 1400 1410 1420 1430 1440
NGRSGDPRPQ AAEPPDHLTI TRRRTWSRDE VMGDNLLLSS VFQFSKKIRQ SIDKTAGKIR
1450 1460 1470 1480 1490 1500
ILFKDKDRNW DDIESKLRAE SEVPIVKTSS MEISSILQEL KRVEKQLQAI NAMIDPDGTL
1510 1520 1530 1540 1550 1560
EALNNMGFPS AMLPSPPKQK SSPVNNHHSP GQTPTLGQPE ARALHPAAVS AAAEFENAES
1570 1580
EADFSIHFNR FNPDGEEEDV TVQE
Isoforms
- Isoform 2 of Centrosomal protein of 170 kDa - Isoform 3 of Centrosomal protein of 170 kDaSequence View
10 20 30 40 50 60
MSLTSWFLVS SGGTRHRLPR EMIFVGRDDC ELMLQSRSVD KQHAVINYDA STDEHLVKDL
70 80 90 100 110 120
GSLNGTFVND VRIPEQTYIT LKLEDKLRFG YDTNLFTVVQ GEMRVPEEAL KHEKFTIQLQ
130 140 150 160 170 180
LSQKSSESEL SKSASAKSID SKVADAATEV QHKTTEALKS EEKAMDISAM PRGTPLYGQP
190 200 210 220 230 240
SWWGDDEVDE KRAFKTNGKP EEKNHEAGTS GCGIDAKQVE EQSAAANEEV LFPFCREPSY
250 260 270 280 290 300
FEIPTKEFQQ PSQITESTIH EIPTKDTPSS HITGAGHASF TIEFDDSTPG KVTIRDHVTK
310 320 330 340 350 360
FTSDQRHKSK KSSPGTQDLL GIQTGMMAPE NKVADWLAQN NPPQMLWERT EEDSKSIKSD
370 380 390 400 410 420
VPVYLKRLKG NKHDDGTQSD SENAGAHRRC SKRATLEEHL RRHHSEHKKL QKVQATEKHQ
430 440 450 460 470 480
DQAVTSSAHH RGGHGVPHGK LLKQKSEEPS VSIPFLQTAL LRSSGSLGHR PSQEMDKMLK
490 500 510 520 530 540
NQATSATSEK DNDDDQSDKG TYTIELENPN SEEVEARKMI DKVFGVDDNQ DYNRPVINEK
550 560 570 580 590 600
HKDLIKDWAL SSAAAVMEER KPLTTSGFHH SEEGTSSSGS KRWVSQWASL AANHTRHDQE
610 620 630 640 650 660
ERIMEFSAPL PLENETEISE SGMTVRSTGS ATSLASQGER RRRTLPQLPN EEKSLESHRA
670 680 690 700 710 720
KVVTQRSEIG EKQDTELQEK ETPTQVYQKD KQDADRPLSK MNRAVNGETL KTGGDNKTLL
730 740 750 760 770 780
HLGSSAPGKE KSETDKETSL VKQTLAKLQQ QEQREEAQWT PTKLSSKNVS GQTDKCREET
790 800 810 820 830 840
FKQESQPPEK NSGHSTSKGD RVAQSESKRR KAEEILKSQT PKGGDKKESS KSLVRQGSFT
850 860 870 880 890 900
IEKPSPNIPI ELIPHINKQT SSTPSSLALT SASRIRERSE SLDPDSSMDT TLILKDTEAV
910 920 930 940 950 960
MAFLEAKLRE DNKTDEGPDT PSYNRDNSIS PESDVDTAST ISLVTGETER KSTQKRKSFT
970 980 990 1000 1010 1020
SLYKDRCSTG SPSKDVTKSS SSGAREKMEK KTKSRSTDVG SRADGRKFVQ SSGRIRQPSV
1030 1040 1050 1060 1070 1080
DLTDDDQTSS VPHSAISDIM SSDQETYSCK PHGRTPLTSA DEHVHSKLEG SKVTKSKTSP
1090 1100 1110 1120 1130 1140
VVSGSSSKST TLPRPRPTRT SLLRRARLGE ASDSELADAD KASVASEVST TSSTSKPPTG
1150 1160 1170 1180 1190 1200
RRNISRIDLL AQPRRTRLGS LSARSDSEAT ISRSSASSRT AEAIIRSGAR LVPSDKFSPR
1210 1220 1230 1240 1250 1260
IRANSISRLS DSKVKSMTSA HGSASVNSRW RRFPTDYAST SEDEFGSNRN SPKHTRLRTS
1270 1280 1290 1300 1310 1320
PALKTTRLQS AGSAMPTSSS FKHRIKEQED YIRDWTAHRE EIARISQDLA LIAREINDVA
1330 1340 1350 1360 1370 1380
GEIDSVTSSG TAPSTTVSTA ATTPGSAIDT REELVDRVFD ESLNFRKIPP LVHSKTPEGN
1390 1400 1410 1420 1430 1440
NGRSGDPRPQ AAEPPDHLTI TRRRTWSRDE VMGDNLLLSS VFQFSKKIRQ SIDKTAGKIR
1450 1460 1470 1480 1490 1500
ILFKDKDRNW DDIESKLRAE SEVPIVKTSS MEISSILQEL KRVEKQLQAI NAMIDPDGTL
1510 1520 1530 1540 1550 1560
EALNNMGFPS AMLPSPPKQK SSPVNNHHSP GQTPTLGQPE ARALHPAAVS AAAEFENAES
1570 1580
EADFSIHFNR FNPDGEEEDV TVQE
10 20 30 40 50 60
MSLTSWFLVS SGGTRHRLPR EMIFVGRDDC ELMLQSRSVD KQHAVINYDA STDEHLVKDL
70 80 90 100 110 120
GSLNGTFVND VRIPEQTYIT LKLEDKLRFG YDTNLFTVVQ GEMRVPEEAL KHEKFTIQLQ
130 140 150 160 170 180
LSQKSSESEL SKSASAKSID SKVADAATEV QHKTTEALKS EEKAMDISAM PRGTPLYGQP
190 200 210 220 230 240
SWWGDDEVDE KRAFKTNGKP EEKNHEAGTS GCGIDAKQVE EQSAAANEEV LFPFCREPSY
250 260 270 280 290 300
FEIPTKEFQQ PSQITESTIH EIPTKDTPSS HITGAGHASF TIEFDDSTPG KVTIRDHVTK
310 320 330 340 350 360
FTSDQRHKSK KSSPGTQDLL GIQTGMMAPE NKVADWLAQN NPPQMLWERT EEDSKSIKSD
370 380 390 400 410 420
VPVYLKRLKG NKHDDGTQSD SENAGAHRRC SKRATLEEHL RRHHSEHKKL QKVQATEKHQ
430 440 450 460 470 480
DQAVTSSAHH RGGHGVPHGK LLKQKSEEPS VSIPFLQTAL LRSSGSLGHR PSQEMDKMLK
490 500 510 520 530 540
NQATSATSEK DNDDDQSDKG TYTIELENPN SEEVEARKMI DKVFGVDDNQ DYNRPVINEK
550 560 570 580 590 600
HKDLIKDWAL SSAAAVMEER KPLTTSGFHH SEEGTSSSGS KRWVSQWASL AANHTRHDQE
610 620 630 640 650 660
ERIMEFSAPL PLENETEISE SGMTVRSTGS ATSLASQGER RRRTLPQLPN EEKSLESHRA
670 680 690 700 710 720
KVVTQRSEIG EKQDTELQEK ETPTQVYQKD KQDADRPLSK MNRAVNGETL KTGGDNKTLL
730 740 750 760 770 780
HLGSSAPGKE KSETDKETSL VKQTLAKLQQ QEQREEAQWT PTKLSSKNVS GQTDKCREET
790 800 810 820 830 840
FKQESQPPEK NSGHSTSKGD RVAQSESKRR KAEEILKSQT PKGGDKKESS KSLVRQGSFT
850 860 870 880 890 900
IEKPSPNIPI ELIPHINKQT SSTPSSLALT SASRIRERSE SLDPDSSMDT TLILKDTEAV
910 920 930 940 950 960
MAFLEAKLRE DNKTDEGPDT PSYNRDNSIS PESDVDTAST ISLVTGETER KSTQKRKSFT
970 980 990 1000 1010 1020
SLYKDRCSTG SPSKDVTKSS SSGAREKMEK KTKSRSTDVG SRADGRKFVQ SSGRIRQPSV
1030 1040 1050 1060 1070 1080
DLTDDDQTSS VPHSAISDIM SSDQETYSCK PHGRTPLTSA DEHVHSKLEG SKVTKSKTSP
1090 1100 1110 1120 1130 1140
VVSGSSSKST TLPRPRPTRT SLLRRARLGE ASDSELADAD KASVASEVST TSSTSKPPTG
1150 1160 1170 1180 1190 1200
RRNISRIDLL AQPRRTRLGS LSARSDSEAT ISRSSASSRT AEAIIRSGAR LVPSDKFSPR
1210 1220 1230 1240 1250 1260
IRANSISRLS DSKVKSMTSA HGSASVNSRW RRFPTDYAST SEDEFGSNRN SPKHTRLRTS
1270 1280 1290 1300 1310 1320
PALKTTRLQS AGSAMPTSSS FKHRIKEQED YIRDWTAHRE EIARISQDLA LIAREINDVA
1330 1340 1350 1360 1370 1380
GEIDSVTSSG TAPSTTVSTA ATTPGSAIDT REELVDRVFD ESLNFRKIPP LVHSKTPEGN
1390 1400 1410 1420 1430 1440
NGRSGDPRPQ AAEPPDHLTI TRRRTWSRDE VMGDNLLLSS VFQFSKKIRQ SIDKTAGKIR
1450 1460 1470 1480 1490 1500
ILFKDKDRNW DDIESKLRAE SEVPIVKTSS MEISSILQEL KRVEKQLQAI NAMIDPDGTL
1510 1520 1530 1540 1550 1560
EALNNMGFPS AMLPSPPKQK SSPVNNHHSP GQTPTLGQPE ARALHPAAVS AAAEFENAES
1570 1580
EADFSIHFNR FNPDGEEEDV TVQE
Protein Neighborhood
Domains & Features
18 N-termini - 5 C-termini - 4 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
Q5SW79-1-unknown | MSLTSW... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
Q5SW79-1-unknown | MSLTSW... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt70197 | |||
Q5SW79-1-unknown | MSLTSW... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt70198 | |||
Q5SW79-286-unknown | DSTPGK... | 286 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC12490 | |||
Q5SW79-286-unknown | DSTPGK... | 286 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt149496 | |||
Q5SW79-286-unknown | DSTPGK... | 286 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt149497 | |||
Q5SW79-607- | SAPLPL... | 607 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
Q5SW79-607-unknown | SAPLPL... | 607 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt172301 | |||
Q5SW79-607-unknown | SAPLPL... | 607 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt172302 | |||
Q5SW79-627- | STGSAT... | 627 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
Q5SW79-627-unknown | STGSAT... | 627 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt177736 | |||
Q5SW79-627-unknown | STGSAT... | 627 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt177737 | |||
Q5SW79-862- | STPSSL... | 862 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
Q5SW79-862- | STPSSL... | 862 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
Q5SW79-862-unknown | STPSSL... | 862 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt168259 | |||
Q5SW79-862-unknown | STPSSL... | 862 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt168260 | |||
Q5SW79-933-unknown | SDVDTA... | 933 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC12493 | |||
Q5SW79-933-unknown | SDVDTA... | 933 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt156632 | |||
Q5SW79-933-unknown | SDVDTA... | 933 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt156633 | |||
Q5SW79-937- | TASTIS... | 937 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
Q5SW79-937- | TASTIS... | 937 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
Q5SW79-937-unknown | TASTIS... | 937 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt173829 | |||
Q5SW79-937-unknown | TASTIS... | 937 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt173830 | |||
Q5SW79-1119-unknown | ADKASV... | 1119 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC12496 | |||
Q5SW79-1119-unknown | ADKASV... | 1119 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt157208 | |||
Q5SW79-1119-unknown | ADKASV... | 1119 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt157209 | |||
Q5SW79-1216-unknown | SMTSAH... | 1216 | unknown | Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... | 18722006 | ||||
Q5SW79-1216-unknown | SMTSAH... | 1216 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt159501 | |||
Q5SW79-1219- | SAHGSA... | 1219 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
Q5SW79-1219-unknown | SAHGSA... | 1219 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt177734 | |||
Q5SW79-1236-unknown | DYASTS... | 1236 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC14569 | |||
Q5SW79-1236-unknown | DYASTS... | 1236 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt157486 | |||
Q5SW79-1325- | SVTSSG... | 1325 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_Etoposide | 23264352 | |||
Q5SW79-1325- | SVTSSG... | 1325 | Subtiligase Based Positive Selection | Wells | apopotic_Jurkat_FasL | 23264352 | |||
Q5SW79-1325- | SVTSSG... | 1325 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
Q5SW79-1325-unknown | SVTSSG... | 1325 | unknown | Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... | 18722006 | ||||
Q5SW79-1325-unknown | SVTSSG... | 1325 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt161370 | |||
Q5SW79-1325-unknown | SVTSSG... | 1325 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt161369 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...TIEFDD | 285 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC12490 | |||
...TIEFDD | 285 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt132881 | |||
...TIEFDD | 285 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt132882 | |||
...SISPES | 932 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC12493 | |||
...SISPES | 932 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt140117 | |||
...SISPES | 932 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt140118 | |||
...SELADA | 1118 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC12496 | |||
...SELADA | 1118 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt140707 | |||
...SELADA | 1118 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt140708 | |||
...RRFPTD | 1235 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC14569 | |||
...RRFPTD | 1235 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt140984 | |||
...VTVQE | 1584 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...VTVQE | 1584 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt65815 | |||
...VTVQE | 1584 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt65816 |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
GRAB_HUMAN | 285 | EFDD.|.DSTP | inferred from experiment | unknown | MEROPS | Gevaert K | Van Damme P et al.:Complementary positional proteo... (M14.017) | 20526345, |
GRAB_HUMAN | 932 | SPES.|.SDVD | inferred from experiment | unknown | MEROPS | Gevaert K | Van Damme P et al.:Complementary positional proteo... (M14.017) | 20526345, |
GRAB_HUMAN | 1118 | LADA.|.ADKA | inferred from experiment | unknown | MEROPS | Gevaert K | Van Damme P et al.:Complementary positional proteo... (M14.017) | 20526345, |
GRAM_HUMAN | 1235 | FPTD.|.DYAS | inferred from experiment | unknown | MEROPS | Bovenschen N | de Poot SA et al.:Human and mouse granzyme M disp... (S01.139) | 21564021, |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|