Q6IBW4: Condensin-2 complex subunit H2

General Information

Protein names	- Condensin-2 complex subunit H2 - Chromosome-associated protein H2 - hCAP-H2 - Kleisin-beta - Non-SMC condensin II complex subunit H2
Gene names	NCAPH2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q6IBW4

8 N-termini

3 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Condensin-2 complex subunit H2 - Isoform 3 of Condensin-2 complex subunit H2 - Isoform 4 of Condensin-2 complex subunit H2

Sequence View

        10         20         30         40         50         60
MEDVEARFAH LLQPIRDLTK NWEVDVAAQL GEYLEELDQI CISFDEGKTT MNFIEAALLI
        70         80         90        100        110        120
QGSACVYSKK VEYLYSLVYQ ALDFISGKRR AKQLSSVQED RANGVASSGV PQEAENEFLS
       130        140        150        160        170        180
LDDFPDSRTN VDLKNDQTPS EVLIIPLLPM ALVAPDEMEK NNNPLYSRQG EVLASRKDFR
       190        200        210        220        230        240
MNTCVPHPRG AFMLEPEGMS PMEPAGVSPM PGTQKDTGRT EEQPMEVSVC RSPVPALGFS
       250        260        270        280        290        300
QEPGPSPEGP MPLGGGEDED AEEAVELPEA SAPKAALEPK ESRSPQQSAA LPRRYMLRER
       310        320        330        340        350        360
EGAPEPASCV KETPDPWQSL DPFDSLESKP FKKGRPYSVP PCVEEALGQK RKRKGAAKLQ
       370        380        390        400        410        420
DFHQWYLAAY ADHADSRRLR RKGPSFADME VLYWTHVKEQ LETLRKLQRR EVAEQWLRPA
       430        440        450        460        470        480
EEDHLEDSLE DLGAADDFLE PEEYMEPEGA DPREAADLDA VPMSLSYEEL VRRNVELFIA
       490        500        510        520        530        540
TSQKFVQETE LSQRIRDWED TVQPLLQEQE QHVPFDIHTY GDQLVSRFPQ LNEWCPFAEL
       550        560        570        580        590        600
VAGQPAFEVC RSMLASLQLA NDYTVEITQQ PGLEMAVDTM SLRLLTHQRA HKRFQTYAAP

SMAQP         10         20         30         40         50         60
MEDVEARFAH LLQPIRDLTK NWEVDVAAQL GEYLEELDQI CISFDEGKTT MNFIEAALLI
        70         80         90        100        110        120
QGSACVYSKK VEYLYSLVYQ ALDFISGKRR AKQLSSVQED RANGVASSGV PQEAENEFLS
       130        140        150        160        170        180
LDDFPDSRTN VDLKNDQTPS EVLIIPLLPM ALVAPDEMEK NNNPLYSRQG EVLASRKDFR
       190        200        210        220        230        240
MNTCVPHPRG AFMLEPEGMS PMEPAGVSPM PGTQKDTGRT EEQPMEVSVC RSPVPALGFS
       250        260        270        280        290        300
QEPGPSPEGP MPLGGGEDED AEEAVELPEA SAPKAALEPK ESRSPQQSAA LPRRYMLRER
       310        320        330        340        350        360
EGAPEPASCV KETPDPWQSL DPFDSLESKP FKKGRPYSVP PCVEEALGQK RKRKGAAKLQ
       370        380        390        400        410        420
DFHQWYLAAY ADHADSRRLR RKGPSFADME VLYWTHVKEQ LETLRKLQRR EVAEQWLRPA
       430        440        450        460        470        480
EEDHLEDSLE DLGAADDFLE PEEYMEPEGA DPREAADLDA VPMSLSYEEL VRRNVELFIA
       490        500        510        520        530        540
TSQKFVQETE LSQRIRDWED TVQPLLQEQE QHVPFDIHTY GDQLVSRFPQ LNEWCPFAEL
       550        560        570        580        590        600
VAGQPAFEVC RSMLASLQLA NDYTVEITQQ PGLEMAVDTM SLRLLTHQRA HKRFQTYAAP

SMAQP         10         20         30         40         50         60
MEDVEARFAH LLQPIRDLTK NWEVDVAAQL GEYLEELDQI CISFDEGKTT MNFIEAALLI
        70         80         90        100        110        120
QGSACVYSKK VEYLYSLVYQ ALDFISGKRR AKQLSSVQED RANGVASSGV PQEAENEFLS
       130        140        150        160        170        180
LDDFPDSRTN VDLKNDQTPS EVLIIPLLPM ALVAPDEMEK NNNPLYSRQG EVLASRKDFR
       190        200        210        220        230        240
MNTCVPHPRG AFMLEPEGMS PMEPAGVSPM PGTQKDTGRT EEQPMEVSVC RSPVPALGFS
       250        260        270        280        290        300
QEPGPSPEGP MPLGGGEDED AEEAVELPEA SAPKAALEPK ESRSPQQSAA LPRRYMLRER
       310        320        330        340        350        360
EGAPEPASCV KETPDPWQSL DPFDSLESKP FKKGRPYSVP PCVEEALGQK RKRKGAAKLQ
       370        380        390        400        410        420
DFHQWYLAAY ADHADSRRLR RKGPSFADME VLYWTHVKEQ LETLRKLQRR EVAEQWLRPA
       430        440        450        460        470        480
EEDHLEDSLE DLGAADDFLE PEEYMEPEGA DPREAADLDA VPMSLSYEEL VRRNVELFIA
       490        500        510        520        530        540
TSQKFVQETE LSQRIRDWED TVQPLLQEQE QHVPFDIHTY GDQLVSRFPQ LNEWCPFAEL
       550        560        570        580        590        600
VAGQPAFEVC RSMLASLQLA NDYTVEITQQ PGLEMAVDTM SLRLLTHQRA HKRFQTYAAP

SMAQP

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

8 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q6IBW4-1-unknown	MEDVEA...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q6IBW4-1-unknown	MEDVEA...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt71117
Q6IBW4-1-unknown	MEDVEA...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt71118
Q6IBW4-1-unknown	MEDVEA...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt71119
Q6IBW4-56-	AALLIQ...	56		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q6IBW4-56-unknown	AALLIQ...	56	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt171107
Q6IBW4-56-unknown	AALLIQ...	56	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt171108
Q6IBW4-56-unknown	AALLIQ...	56	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt171109
Q6IBW4-104-	GVASSG...	104		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q6IBW4-104-	GVASSG...	104		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q6IBW4-104-unknown	GVASSG...	104	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt171103
Q6IBW4-104-unknown	GVASSG...	104	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt171104
Q6IBW4-104-unknown	GVASSG...	104	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt171105
Q6IBW4-443-unknown	EYMEPE...	443	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12570
Q6IBW4-443-unknown	EYMEPE...	443	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152347
Q6IBW4-443-unknown	EYMEPE...	443	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt199427
Q6IBW4-460-unknown	AVPMSL...	460	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt168180
Q6IBW4-460-unknown	AVPMSL...	460	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt168179
Q6IBW4-460-	AVPMSL...	460		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q6IBW4-460-	AVPMSL...	460		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q6IBW4-460-	AVPMSL...	460		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...FLEPEE	442	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12570
...FLEPEE	442	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt135758
...SMAQP	605		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...SMAQP	605		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...SMAQP	605	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...SMAQP	605	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt66735
...SMAQP	605	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt66737
...SMAQP	605		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...SMAQP	605		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	442	EPEE.\|.EYME	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)