Q71U36: Tubulin alpha-1A chain

General Information

Protein names	- Tubulin alpha-1A chain - Alpha-tubulin 3 - Tubulin B-alpha-1 - Tubulin alpha-3 chain - Detyrosinated tubulin alpha-1A chain
Gene names	TUBA1A
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q71U36

31 N-termini

30 C-termini

31 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MRECISIHVG QAGVQIGNAC WELYCLEHGI QPDGQMPSDK TIGGGDDSFN TFFSETGAGK
        70         80         90        100        110        120
HVPRAVFVDL EPTVIDEVRT GTYRQLFHPE QLITGKEDAA NNYARGHYTI GKEIIDLVLD
       130        140        150        160        170        180
RIRKLADQCT GLQGFLVFHS FGGGTGSGFT SLLMERLSVD YGKKSKLEFS IYPAPQVSTA
       190        200        210        220        230        240
VVEPYNSILT THTTLEHSDC AFMVDNEAIY DICRRNLDIE RPTYTNLNRL IGQIVSSITA
       250        260        270        280        290        300
SLRFDGALNV DLTEFQTNLV PYPRIHFPLA TYAPVISAEK AYHEQLSVAE ITNACFEPAN
       310        320        330        340        350        360
QMVKCDPRHG KYMACCLLYR GDVVPKDVNA AIATIKTKRT IQFVDWCPTG FKVGINYQPP
       370        380        390        400        410        420
TVVPGGDLAK VQRAVCMLSN TTAIAEAWAR LDHKFDLMYA KRAFVHWYVG EGMEEGEFSE
       430        440        450
AREDMAALEK DYEEVGVDSV EGEGEEEGEE Y

Isoforms

- Isoform 2 of Tubulin alpha-1A chain

Sequence View

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Protein Neighborhood

Domains & Features

31 N-termini - 30 C-termini - 31 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q71U36-1-unknown	MRECIS...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q71U36-36-unknown	MPSDKT...	36	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt91578
Q71U36-41-unknown	TIGGGD...	41	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10371
Q71U36-41-unknown	TIGGGD...	41	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt195912
Q71U36-57-unknown	GAGKHV...	57	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15462
Q71U36-57-unknown	GAGKHV...	57	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt136991
Q71U36-65-unknown	AVFVDL...	65	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10372
Q71U36-65-unknown	AVFVDL...	65	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt137555
Q71U36-66-unknown	VFVDLE...	66	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15464
Q71U36-66-unknown	VFVDLE...	66	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt137622
Q71U36-67-unknown	FVDLEP...	67	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15466
Q71U36-67-unknown	FVDLEP...	67	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt137694
Q71U36-69-unknown	DLEPTV...	69	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15468
Q71U36-69-unknown	DLEPTV...	69	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt137875
Q71U36-70-unknown	LEPTVI...	70	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12644
Q71U36-70-unknown	LEPTVI...	70	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15470
Q71U36-70-unknown	LEPTVI...	70	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt137966
Q71U36-71-unknown	EPTVID...	71	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12646
Q71U36-71-unknown	EPTVID...	71	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt138024
Q71U36-85-unknown	QLFHPE...	85	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10374
Q71U36-85-unknown	QLFHPE...	85	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt139181
Q71U36-91-unknown	QLITGK...	91	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12648
Q71U36-91-unknown	QLITGK...	91	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt139603
Q71U36-93-unknown	ITGKED...	93	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15472
Q71U36-93-unknown	ITGKED...	93	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt139739
Q71U36-136-unknown	LVFHSF...	136	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14636
Q71U36-136-unknown	LVFHSF...	136	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt142440
Q71U36-138-unknown	FHSFGG...	138	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15474
Q71U36-138-unknown	FHSFGG...	138	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt142551
Q71U36-201-unknown	AFMVDN...	201	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14638
Q71U36-201-unknown	AFMVDN...	201	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15476
Q71U36-201-unknown	AFMVDN...	201	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt145363
Q71U36-205-unknown	DNEAIY...	205	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15478
Q71U36-205-unknown	DNEAIY...	205	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt145532
Q71U36-208-unknown	AIYDIC...	208	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12650
Q71U36-208-unknown	AIYDIC...	208	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt145627
Q71U36-252-unknown	LTEFQT...	252	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12652
Q71U36-252-unknown	LTEFQT...	252	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt147237
Q71U36-254-unknown	EFQTNL...	254	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15480
Q71U36-254-unknown	EFQTNL...	254	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt147319
Q71U36-270-unknown	ATYAPV...	270	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14640
Q71U36-270-unknown	ATYAPV...	270	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt147914
Q71U36-287-unknown	SVAEIT...	287	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14642
Q71U36-287-unknown	SVAEIT...	287	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt148478
Q71U36-292-unknown	TNACFE...	292	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15482
Q71U36-292-unknown	TNACFE...	292	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt148718
Q71U36-329-unknown	NAAIAT...	329	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15484
Q71U36-329-unknown	NAAIAT...	329	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt149702
Q71U36-353-unknown	VGINYQ...	353	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10376
Q71U36-353-unknown	VGINYQ...	353	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt150287
Q71U36-354-unknown	GINYQP...	354	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15486
Q71U36-354-unknown	GINYQP...	354	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt150303
Q71U36-356-unknown	NYQPPT...	356	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14644
Q71U36-356-unknown	NYQPPT...	356	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt150352
Q71U36-408-unknown	YVGEGM...	408	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15488
Q71U36-408-unknown	YVGEGM...	408	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt151462
Q71U36-414-unknown	EEGEFS...	414	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15490
Q71U36-414-unknown	EEGEFS...	414	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt151586
Q71U36-432-unknown	YEEVGV...	432	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12654
Q71U36-432-unknown	YEEVGV...	432	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt151954
Q71U36-439-unknown	SVEGEG...	439	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12656
Q71U36-439-unknown	SVEGEG...	439	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt152053

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...MPSDKT	40	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10371
...FFSETG	56	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15462
...FFSETG	56	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt119832
...KHVPRA	64	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10372
...KHVPRA	64	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120540
...HVPRAV	65	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15464
...HVPRAV	65	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120616
...VPRAVF	66	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15466
...VPRAVF	66	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120693
...RAVFVD	68	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15468
...RAVFVD	68	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120882
...AVFVDL	69	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12644
...AVFVDL	69	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15470
...AVFVDL	69	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120975
...VFVDLE	70	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12646
...VFVDLE	70	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt121040
...TGTYRQ	84	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10374
...TGTYRQ	84	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122256
...LFHPEQ	90	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12648
...LFHPEQ	90	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122695
...HPEQLI	92	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15472
...HPEQLI	92	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122838
...GLQGFL	135	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14636
...GLQGFL	135	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125634
...QGFLVF	137	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15474
...QGFLVF	137	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125746
...EHSDCA	200	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14638
...EHSDCA	200	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15476
...EHSDCA	200	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128656
...CAFMVD	204	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15478
...CAFMVD	204	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128830
...MVDNEA	207	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12650
...MVDNEA	207	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128926
...ALNVDL	251	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12652
...ALNVDL	251	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130580
...NVDLTE	253	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15480
...NVDLTE	253	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130662
...IHFPLA	269	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14640
...IHFPLA	269	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131274
...YHEQLS	286	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14642
...YHEQLS	286	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131851
...SVAEIT	291	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15482
...SVAEIT	291	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132093
...VPKDVN	328	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15484
...VPKDVN	328	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133091
...PTGFKV	352	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10376
...PTGFKV	352	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133682
...TGFKVG	353	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15486
...TGFKVG	353	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133698
...FKVGIN	355	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14644
...FKVGIN	355	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133749
...AFVHWY	407	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15488
...AFVHWY	407	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134867
...VGEGME	413	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15490
...VGEGME	413	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134992
...ALEKDY	431	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12654
...ALEKDY	431	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135362
...EVGVDS	438	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12656
...EVGVDS	438	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135463
...EGEEY	451	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...EGEEY	451	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt87196

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAA_HUMAN	40	SDKT.\|.TIGG	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
HTRA2_HUMAN	56	SETG.\|.GAGK	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,
GRAA_HUMAN	64	VPRA.\|.AVFV	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
HTRA2_HUMAN	65	PRAV.\|.VFVD	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,
HTRA2_HUMAN	66	RAVF.\|.FVDL	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,
HTRA2_HUMAN	68	VFVD.\|.DLEP	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,
GRAB_HUMAN	69	FVDL.\|.LEPT	inferred from experiment	unknown	MEROPS		Merops GRAB_HUMAN -> TBA1A_HUMAN @69
GRAB_HUMAN	69	FVDL.\|.LEPT	inferred from experiment	unknown	MEROPS	Gevaert K	Plasman K et al.:Probing the efficiency of prote... (S01.010)	21048194,
HTRA2_HUMAN	69	FVDL.\|.LEPT	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,
GRAB_HUMAN	70	VDLE.\|.EPTV	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
GRAA_HUMAN	84	TYRQ.\|.QLFH	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
GRAB_HUMAN	90	HPEQ.\|.QLIT	inferred from experiment	unknown	MEROPS		Merops GRAB_HUMAN -> TBA1A_HUMAN @90
GRAB_HUMAN	90	HPEQ.\|.QLIT	inferred from experiment	unknown	MEROPS	Gevaert K	Plasman K et al.:Probing the efficiency of prote... (S01.010)	21048194,
HTRA2_HUMAN	92	EQLI.\|.ITGK	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,
GRAM_HUMAN	135	QGFL.\|.LVFH	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
HTRA2_HUMAN	137	FLVF.\|.FHSF	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,
GRAM_HUMAN	200	SDCA.\|.AFMV	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
HTRA2_HUMAN	200	SDCA.\|.AFMV	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,
HTRA2_HUMAN	204	FMVD.\|.DNEA	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,
GRAB_HUMAN	207	DNEA.\|.AIYD	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
GRAB_HUMAN	251	NVDL.\|.LTEF	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
HTRA2_HUMAN	253	DLTE.\|.EFQT	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,
GRAM_HUMAN	269	FPLA.\|.ATYA	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAM_HUMAN	286	EQLS.\|.SVAE	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
HTRA2_HUMAN	291	AEIT.\|.TNAC	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,
HTRA2_HUMAN	328	KDVN.\|.NAAI	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,
GRAA_HUMAN	352	GFKV.\|.VGIN	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
HTRA2_HUMAN	353	FKVG.\|.GINY	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,
GRAM_HUMAN	355	VGIN.\|.NYQP	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
HTRA2_HUMAN	407	VHWY.\|.YVGE	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,
HTRA2_HUMAN	413	EGME.\|.EEGE	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,
GRAB_HUMAN	431	EKDY.\|.YEEV	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
GRAB_HUMAN	438	GVDS.\|.SVEG	inferred from experiment	unknown	MEROPS	Martin SJ	Adrain C et al.:The cytotoxic lymphocyte protea... (S01.010)	16415351,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)