Q71UI9: Histone H2A.V

General Information

Protein names	- Histone H2A.V - H2A.F/Z
Gene names	H2AFV
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q71UI9

6 N-termini

6 C-termini

4 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Histone H2A.V - Isoform 3 of Histone H2A.V - Isoform 4 of Histone H2A.V - Isoform 5 of Histone H2A.V

Sequence View

        10         20         30         40         50         60
MAGGKAGKDS GKAKAKAVSR SQRAGLQFPV GRIHRHLKTR TTSHGRVGAT AAVYSAAILE
        70         80         90        100        110        120
YLTAEVLELA GNASKDLKVK RITPRHLQLA IRGDEELDSL IKATIAGGGV IPHIHKSLIG

KKGQQKTA         10         20         30         40         50         60
MAGGKAGKDS GKAKAKAVSR SQRAGLQFPV GRIHRHLKTR TTSHGRVGAT AAVYSAAILE
        70         80         90        100        110        120
YLTAEVLELA GNASKDLKVK RITPRHLQLA IRGDEELDSL IKATIAGGGV IPHIHKSLIG

KKGQQKTA         10         20         30         40         50         60
MAGGKAGKDS GKAKAKAVSR SQRAGLQFPV GRIHRHLKTR TTSHGRVGAT AAVYSAAILE
        70         80         90        100        110        120
YLTAEVLELA GNASKDLKVK RITPRHLQLA IRGDEELDSL IKATIAGGGV IPHIHKSLIG

KKGQQKTA         10         20         30         40         50         60
MAGGKAGKDS GKAKAKAVSR SQRAGLQFPV GRIHRHLKTR TTSHGRVGAT AAVYSAAILE
        70         80         90        100        110        120
YLTAEVLELA GNASKDLKVK RITPRHLQLA IRGDEELDSL IKATIAGGGV IPHIHKSLIG

KKGQQKTA

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

6 N-termini - 6 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q71UI9-1-unknown	MAGGKA...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q71UI9-1-unknown	MAGGKA...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt76692
Q71UI9-1-unknown	MAGGKA...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt76693
Q71UI9-1-unknown	MAGGKA...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt76695
Q71UI9-2-unknown	AGGKAG...	2		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q71UI9-2-unknown	AGGKAG...	2		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q71UI9-2-unknown	AGGKAG...	2	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162640
Q71UI9-2-unknown	AGGKAG...	2	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162641
Q71UI9-2-unknown	AGGKAG...	2	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162642
Q71UI9-2-unknown	AGGKAG...	2	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q71UI9-10-unknown	SGKAKA...	10	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12658
Q71UI9-10-unknown	SGKAKA...	10	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt194867
Q71UI9-10-unknown	SGKAKA...	10	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt194868
Q71UI9-24-unknown	AGLQFP...	24	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10378
Q71UI9-24-unknown	AGLQFP...	24	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt137136
Q71UI9-24-unknown	AGLQFP...	24	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt137137
Q71UI9-63-unknown	TAEVLE...	63	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14646
Q71UI9-63-unknown	TAEVLE...	63	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt138092
Q71UI9-63-unknown	TAEVLE...	63	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt140164
Q71UI9-86-unknown	HLQLAI...	86	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10381
Q71UI9-86-unknown	HLQLAI...	86	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt139016
Q71UI9-86-unknown	HLQLAI...	86	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt139925
Q71UI9-86-unknown	HLQLAI...	86	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt141641

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...KAGKDS	9	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12658
...SRSQRA	23	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10378
...SRSQRA	23	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120028
...SRSQRA	23	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120029
...SRSQRA	23	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt153699
...ILEYLT	62	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14646
...ILEYLT	62	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt121114
...ILEYLT	62	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt123274
...ILEYLT	62	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt153781
...LTAEVL	66	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72313
...LTAEVL	66	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt91395
...LTAEVL	66	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt91396
...RITPRH	85	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10381
...RITPRH	85	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt123030
...RITPRH	85	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124820
...QQKTA	128	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...QQKTA	128	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72311
...QQKTA	128	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72312

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	9	GKDS.\|.SGKA	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
GRAA_HUMAN	23	SQRA.\|.AGLQ	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
GRAM_HUMAN	62	EYLT.\|.TAEV	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAA_HUMAN	85	TPRH.\|.HLQL	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)