Q7Z422: SUZ domain-containing protein 1

General Information

Protein names	- SUZ domain-containing protein 1 - Putative MAPK-activating protein PM18/PM20/PM22
Gene names	SZRD1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q7Z422

7 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of SUZ domain-containing protein 1 - Isoform 3 of SUZ domain-containing protein 1 - Isoform 4 of SUZ domain-containing protein 1 - Isoform 5 of SUZ domain-containing protein 1

Sequence View

        10         20         30         40         50         60
MEDEEVAESW EEAADSGEID RRLEKKLKIT QKESRKSKSP PKVPIVIQDD SLPAGPPPQI
        70         80         90        100        110        120
RILKRPTSNG VVSSPNSTSR PTLPVKSLAQ REAEYAEARK RILGSASPEE EQEKPILDRP
       130        140        150
TRISQPEDSR QPNNVIRQPL GPDGSQGFKQ RR         10         20         30         40         50         60
MEDEEVAESW EEAADSGEID RRLEKKLKIT QKESRKSKSP PKVPIVIQDD SLPAGPPPQI
        70         80         90        100        110        120
RILKRPTSNG VVSSPNSTSR PTLPVKSLAQ REAEYAEARK RILGSASPEE EQEKPILDRP
       130        140        150
TRISQPEDSR QPNNVIRQPL GPDGSQGFKQ RR         10         20         30         40         50         60
MEDEEVAESW EEAADSGEID RRLEKKLKIT QKESRKSKSP PKVPIVIQDD SLPAGPPPQI
        70         80         90        100        110        120
RILKRPTSNG VVSSPNSTSR PTLPVKSLAQ REAEYAEARK RILGSASPEE EQEKPILDRP
       130        140        150
TRISQPEDSR QPNNVIRQPL GPDGSQGFKQ RR         10         20         30         40         50         60
MEDEEVAESW EEAADSGEID RRLEKKLKIT QKESRKSKSP PKVPIVIQDD SLPAGPPPQI
        70         80         90        100        110        120
RILKRPTSNG VVSSPNSTSR PTLPVKSLAQ REAEYAEARK RILGSASPEE EQEKPILDRP
       130        140        150
TRISQPEDSR QPNNVIRQPL GPDGSQGFKQ RR

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

7 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q7Z422-1-Acetylation	MEDEEV...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q7Z422-51-unknown	SLPAGP...	51		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12677
Q7Z422-51-unknown	SLPAGP...	51		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt137634
Q7Z422-51-unknown	SLPAGP...	51		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt137712
Q7Z422-51-unknown	SLPAGP...	51		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt137809
Q7Z422-51-	SLPAGP...	51			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q7Z422-70-unknown	GVVSSP...	70		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172663
Q7Z422-70-unknown	GVVSSP...	70		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172661
Q7Z422-70-unknown	GVVSSP...	70		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172662
Q7Z422-70-	GVVSSP...	70			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q7Z422-105-unknown	SASPEE...	105		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177098
Q7Z422-105-unknown	SASPEE...	105		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177096
Q7Z422-105-unknown	SASPEE...	105		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177097
Q7Z422-105-	SASPEE...	105			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...VIQDDS	50	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12677
...FKQRR	152	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...FKQRR	152	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt86949
...FKQRR	152	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt86951
...FKQRR	152	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt86950

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	50	QDDS.\|.SLPA	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)