Q7Z6I6: Rho GTPase-activating protein 30

General Information

Protein names	- Rho GTPase-activating protein 30 - Rho-type GTPase-activating protein 30
Gene names	ARHGAP30
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q7Z6I6

17 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Rho GTPase-activating protein 30 - Isoform 3 of Rho GTPase-activating protein 30 - Isoform 4 of Rho GTPase-activating protein 30

Sequence View

        10         20         30         40         50         60
MKSRQKGKKK GSAKERVFGC DLQEHLQHSG QEVPQVLKSC AEFVEEYGVV DGIYRLSGVS
        70         80         90        100        110        120
SNIQKLRQEF ESERKPDLRR DVYLQDIHCV SSLCKAYFRE LPDPLLTYRL YDKFAEAVGV
       130        140        150        160        170        180
QLEPERLVKI LEVLRELPVP NYRTLEFLMR HLVHMASFSA QTNMHARNLA IVWAPNLLRS
       190        200        210        220        230        240
KDIEASGFNG TAAFMEVRVQ SIVVEFILTH VDQLFGGAAL SGGEVESGWR SLPGTRASGS
       250        260        270        280        290        300
PEDLMPRPLP YHLPSILQAG DGPPQMRPYH TIIEIAEHKR KGSLKVRKWR SIFNLGRSGH
       310        320        330        340        350        360
ETKRKLPRGA EDREDKSNKG TLRPAKSMDS LSAAAGASDE PEGLVGPSSP RPSPLLPESL
       370        380        390        400        410        420
ENDSIEAAEG EQEPEAEALG GTNSEPGTPR AGRSAIRAGG SSRAERCAGV HISDPYNVNL
       430        440        450        460        470        480
PLHITSILSV PPNIISNVSL ARLTRGLECP ALQHRPSPAS GPGPGPGLGP GPPDEKLEAS
       490        500        510        520        530        540
PASSPLADSG PDDLAPALED SLSQEVQDSF SFLEDSSSSE PEWVGAEDGE VAQAEAAGAA
       550        560        570        580        590        600
FSPGEDDPGM GYLEELLGVG PQVEEFSVEP PLDDLSLDEA QFVLAPSCCS LDSAGPRPEV
       610        620        630        640        650        660
EEENGEEVFL SAYDDLSPLL GPKPPIWKGS GSLEGEAAGC GRQALGQGGE EQACWEVGED
       670        680        690        700        710        720
KQAEPGGRLD IREEAEGSPE TKVEAGKASE DRGEAGGSQE TKVRLREGSR EETEAKEEKS
       730        740        750        760        770        780
KGQKKADSME AKGVEEPGGD EYTDEKEKEI EREEDEQREE AQVEAGRDLE QGAQEDQVAE
       790        800        810        820        830        840
EKWEVVQKQE AEGVREDEDK GQREKGYHEA RKDQGDGEDS RSPEAATEGG AGEVSKERES
       850        860        870        880        890        900
GDGEAEGDQR AGGYYLEEDT LSEGSGVASL EVDCAKEGNP HSSEMEEVAP QPPQPEEMEP
       910        920        930        940        950        960
EGQPSPDGCL CPCSLGLGGV GMRLASTLVQ VQQVRSVPVV PPKPQFAKMP SAMCSKIHVA
       970        980        990       1000       1010       1020
PANPCPRPGR LDGTPGERAW GSRASRSSWR NGGSLSFDAA VALARDRQRT EAQGVRRTQT
      1030       1040       1050       1060       1070       1080
CTEGGDYCLI PRTSPCSMIS AHSPRPLSCL ELPSEGAEGS GSRSRLSLPP REPQVPDPLL
      1090       1100
SSQRRSYAFE TQANPGKGEG L         10         20         30         40         50         60
MKSRQKGKKK GSAKERVFGC DLQEHLQHSG QEVPQVLKSC AEFVEEYGVV DGIYRLSGVS
        70         80         90        100        110        120
SNIQKLRQEF ESERKPDLRR DVYLQDIHCV SSLCKAYFRE LPDPLLTYRL YDKFAEAVGV
       130        140        150        160        170        180
QLEPERLVKI LEVLRELPVP NYRTLEFLMR HLVHMASFSA QTNMHARNLA IVWAPNLLRS
       190        200        210        220        230        240
KDIEASGFNG TAAFMEVRVQ SIVVEFILTH VDQLFGGAAL SGGEVESGWR SLPGTRASGS
       250        260        270        280        290        300
PEDLMPRPLP YHLPSILQAG DGPPQMRPYH TIIEIAEHKR KGSLKVRKWR SIFNLGRSGH
       310        320        330        340        350        360
ETKRKLPRGA EDREDKSNKG TLRPAKSMDS LSAAAGASDE PEGLVGPSSP RPSPLLPESL
       370        380        390        400        410        420
ENDSIEAAEG EQEPEAEALG GTNSEPGTPR AGRSAIRAGG SSRAERCAGV HISDPYNVNL
       430        440        450        460        470        480
PLHITSILSV PPNIISNVSL ARLTRGLECP ALQHRPSPAS GPGPGPGLGP GPPDEKLEAS
       490        500        510        520        530        540
PASSPLADSG PDDLAPALED SLSQEVQDSF SFLEDSSSSE PEWVGAEDGE VAQAEAAGAA
       550        560        570        580        590        600
FSPGEDDPGM GYLEELLGVG PQVEEFSVEP PLDDLSLDEA QFVLAPSCCS LDSAGPRPEV
       610        620        630        640        650        660
EEENGEEVFL SAYDDLSPLL GPKPPIWKGS GSLEGEAAGC GRQALGQGGE EQACWEVGED
       670        680        690        700        710        720
KQAEPGGRLD IREEAEGSPE TKVEAGKASE DRGEAGGSQE TKVRLREGSR EETEAKEEKS
       730        740        750        760        770        780
KGQKKADSME AKGVEEPGGD EYTDEKEKEI EREEDEQREE AQVEAGRDLE QGAQEDQVAE
       790        800        810        820        830        840
EKWEVVQKQE AEGVREDEDK GQREKGYHEA RKDQGDGEDS RSPEAATEGG AGEVSKERES
       850        860        870        880        890        900
GDGEAEGDQR AGGYYLEEDT LSEGSGVASL EVDCAKEGNP HSSEMEEVAP QPPQPEEMEP
       910        920        930        940        950        960
EGQPSPDGCL CPCSLGLGGV GMRLASTLVQ VQQVRSVPVV PPKPQFAKMP SAMCSKIHVA
       970        980        990       1000       1010       1020
PANPCPRPGR LDGTPGERAW GSRASRSSWR NGGSLSFDAA VALARDRQRT EAQGVRRTQT
      1030       1040       1050       1060       1070       1080
CTEGGDYCLI PRTSPCSMIS AHSPRPLSCL ELPSEGAEGS GSRSRLSLPP REPQVPDPLL
      1090       1100
SSQRRSYAFE TQANPGKGEG L         10         20         30         40         50         60
MKSRQKGKKK GSAKERVFGC DLQEHLQHSG QEVPQVLKSC AEFVEEYGVV DGIYRLSGVS
        70         80         90        100        110        120
SNIQKLRQEF ESERKPDLRR DVYLQDIHCV SSLCKAYFRE LPDPLLTYRL YDKFAEAVGV
       130        140        150        160        170        180
QLEPERLVKI LEVLRELPVP NYRTLEFLMR HLVHMASFSA QTNMHARNLA IVWAPNLLRS
       190        200        210        220        230        240
KDIEASGFNG TAAFMEVRVQ SIVVEFILTH VDQLFGGAAL SGGEVESGWR SLPGTRASGS
       250        260        270        280        290        300
PEDLMPRPLP YHLPSILQAG DGPPQMRPYH TIIEIAEHKR KGSLKVRKWR SIFNLGRSGH
       310        320        330        340        350        360
ETKRKLPRGA EDREDKSNKG TLRPAKSMDS LSAAAGASDE PEGLVGPSSP RPSPLLPESL
       370        380        390        400        410        420
ENDSIEAAEG EQEPEAEALG GTNSEPGTPR AGRSAIRAGG SSRAERCAGV HISDPYNVNL
       430        440        450        460        470        480
PLHITSILSV PPNIISNVSL ARLTRGLECP ALQHRPSPAS GPGPGPGLGP GPPDEKLEAS
       490        500        510        520        530        540
PASSPLADSG PDDLAPALED SLSQEVQDSF SFLEDSSSSE PEWVGAEDGE VAQAEAAGAA
       550        560        570        580        590        600
FSPGEDDPGM GYLEELLGVG PQVEEFSVEP PLDDLSLDEA QFVLAPSCCS LDSAGPRPEV
       610        620        630        640        650        660
EEENGEEVFL SAYDDLSPLL GPKPPIWKGS GSLEGEAAGC GRQALGQGGE EQACWEVGED
       670        680        690        700        710        720
KQAEPGGRLD IREEAEGSPE TKVEAGKASE DRGEAGGSQE TKVRLREGSR EETEAKEEKS
       730        740        750        760        770        780
KGQKKADSME AKGVEEPGGD EYTDEKEKEI EREEDEQREE AQVEAGRDLE QGAQEDQVAE
       790        800        810        820        830        840
EKWEVVQKQE AEGVREDEDK GQREKGYHEA RKDQGDGEDS RSPEAATEGG AGEVSKERES
       850        860        870        880        890        900
GDGEAEGDQR AGGYYLEEDT LSEGSGVASL EVDCAKEGNP HSSEMEEVAP QPPQPEEMEP
       910        920        930        940        950        960
EGQPSPDGCL CPCSLGLGGV GMRLASTLVQ VQQVRSVPVV PPKPQFAKMP SAMCSKIHVA
       970        980        990       1000       1010       1020
PANPCPRPGR LDGTPGERAW GSRASRSSWR NGGSLSFDAA VALARDRQRT EAQGVRRTQT
      1030       1040       1050       1060       1070       1080
CTEGGDYCLI PRTSPCSMIS AHSPRPLSCL ELPSEGAEGS GSRSRLSLPP REPQVPDPLL
      1090       1100
SSQRRSYAFE TQANPGKGEG L

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

17 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q7Z6I6-1-unknown	MKSRQK...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q7Z6I6-1-unknown	MKSRQK...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt87671
Q7Z6I6-1-unknown	MKSRQK...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt87673
Q7Z6I6-149-unknown	MRHLVH...	149	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt87672
Q7Z6I6-149-unknown	MRHLVH...	149	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt102742
Q7Z6I6-149-unknown	MRHLVH...	149	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt102743
Q7Z6I6-343-	GLVGPS...	343		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q7Z6I6-343-	GLVGPS...	343		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q7Z6I6-343-unknown	GLVGPS...	343	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170804
Q7Z6I6-343-unknown	GLVGPS...	343	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170805
Q7Z6I6-364-	SIEAAE...	364		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q7Z6I6-364-	SIEAAE...	364		Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
Q7Z6I6-364-	SIEAAE...	364		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q7Z6I6-364-	SIEAAE...	364		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q7Z6I6-364-	SIEAAE...	364		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q7Z6I6-364-	SIEAAE...	364		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q7Z6I6-364-unknown	SIEAAE...	364		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q7Z6I6-364-unknown	SIEAAE...	364	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162004
Q7Z6I6-364-unknown	SIEAAE...	364	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162005
Q7Z6I6-367-unknown	AAEGEQ...	367	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173560
Q7Z6I6-367-unknown	AAEGEQ...	367	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173561
Q7Z6I6-367-	AAEGEQ...	367		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q7Z6I6-367-	AAEGEQ...	367		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q7Z6I6-367-	AAEGEQ...	367		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q7Z6I6-370-	GEQEPE...	370		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q7Z6I6-370-	GEQEPE...	370		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q7Z6I6-370-	GEQEPE...	370		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q7Z6I6-370-unknown	GEQEPE...	370		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q7Z6I6-370-unknown	GEQEPE...	370	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162001
Q7Z6I6-370-unknown	GEQEPE...	370	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162002
Q7Z6I6-429-unknown	SVPPNI...	429	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167861
Q7Z6I6-429-unknown	SVPPNI...	429	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167862
Q7Z6I6-429-	SVPPNI...	429		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q7Z6I6-593-	SAGPRP...	593		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q7Z6I6-593-unknown	SAGPRP...	593	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt174915
Q7Z6I6-593-unknown	SAGPRP...	593	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt174916
Q7Z6I6-860-unknown	TLSEGS...	860	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12702
Q7Z6I6-860-unknown	TLSEGS...	860	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt155974
Q7Z6I6-936-unknown	SVPVVP...	936	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167859
Q7Z6I6-936-unknown	SVPVVP...	936	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167858
Q7Z6I6-936-	SVPVVP...	936		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...YLEEDT	859	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12702
...YLEEDT	859	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt139432
...KGEGL	1101	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...KGEGL	1101	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt83289
...KGEGL	1101	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt83290

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	859	EEDT.\|.TLSE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)