Q7Z739: YTH domain-containing family protein 3 {ECO:0000305}

General Information

Protein names	- YTH domain-containing family protein 3 {ECO:0000305}
Gene names	YTHDF3
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q7Z739

10 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSATSVDQRP KGQGNKVSVQ NGSIHQKDAV NDDDFEPYLS SQTNQSNSYP PMSDPYMPSY
        70         80         90        100        110        120
YAPSIGFPYS LGEAAWSTAG DQPMPYLTTY GQMSNGEHHY IPDGVFSQPG ALGNTPPFLG
       130        140        150        160        170        180
QHGFNFFPGN ADFSTWGTSG SQGQSTQSSA YSSSYGYPPS SLGRAITDGQ AGFGNDTLSK
       190        200        210        220        230        240
VPGISSIEQG MTGLKIGGDL TAAVTKTVGT ALSSSGMTSI ATNSVPPVSS AAPKPTSWAA
       250        260        270        280        290        300
IARKPAKPQP KLKPKGNVGI GGSAVPPPPI KHNMNIGTWD EKGSVVKAPP TQPVLPPQTI
       310        320        330        340        350        360
IQQPQPLIQP PPLVQSQLPQ QQPQPPQPQQ QQGPQPQAQP HQVQPQQQQL QNRWVAPRNR
       370        380        390        400        410        420
GAGFNQNNGA GSENFGLGVV PVSASPSSVE VHPVLEKLKA INNYNPKDFD WNLKNGRVFI
       430        440        450        460        470        480
IKSYSEDDIH RSIKYSIWCS TEHGNKRLDA AYRSLNGKGP LYLLFSVNGS GHFCGVAEMK
       490        500        510        520        530        540
SVVDYNAYAG VWSQDKWKGK FEVKWIFVKD VPNNQLRHIR LENNDNKPVT NSRDTQEVPL
       550        560        570        580
EKAKQVLKII ATFKHTTSIF DDFAHYEKRQ EEEEAMRRER NRNKQ

Isoforms

Sequence View

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Evidence Names:

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Protein Neighborhood

Domains & Features

10 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q7Z739-2-unknown	MSATSV...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q7Z739-2-Acetylation	SATSVD...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q7Z739-2-Acetylation	SATSVD...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q7Z739-2-Acetylation	SATSVD...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q7Z739-169-unknown	GQAGFG...	169			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q7Z739-169-	GQAGFG...	169			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q7Z739-169-	GQAGFG...	169			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q7Z739-169-	GQAGFG...	169			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q7Z739-172-unknown	GFGNDT...	172			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q7Z739-172-	GFGNDT...	172			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q7Z739-172-	GFGNDT...	172			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q7Z739-177-unknown	TLSKVP...	177		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12742
Q7Z739-224-	SVPPVS...	224			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q7Z739-224-	SVPPVS...	224			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q7Z739-224-	SVPPVS...	224			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q7Z739-224-	SVPPVS...	224			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q7Z739-230-	SAAPKP...	230			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q7Z739-230-	SAAPKP...	230			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q7Z739-230-	SAAPKP...	230			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q7Z739-337-	QAQPHQ...	337			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...GFGNDT	176	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12742
	...NRNKQ	585	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	176	GNDT.\|.TLSK	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)