Q86UE4: Protein LYRIC

General Information

Protein names	- Protein LYRIC - 3D3/LYRIC - Astrocyte elevated gene-1 protein - AEG-1 - Lysine-rich CEACAM1 co-isolated protein - Metadherin - Metastasis adhesion protein
Gene names	MTDH
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q86UE4

15 N-termini

4 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAARSWQDEL AQQAEEGSAR LREMLSVGLG FLRTELGLDL GLEPKRYPGW VILVGTGALG
        70         80         90        100        110        120
LLLLFLLGYG WAAACAGARK KRRSPPRKRE EAAAVPAAAP DDLALLKNLR SEEQKKKNRK
       130        140        150        160        170        180
KLSEKPKPNG RTVEVAEGEA VRTPQSVTAK QPPEIDKKNE KSKKNKKKSK SDAKAVQNSS
       190        200        210        220        230        240
RHDGKEVDEG AWETKISHRE KRQQRKRDKV LTDSGSLDST IPGIENTITV TTEQLTTASF
       250        260        270        280        290        300
PVGSKKNKGD SHLNVQVSNF KSGKGDSTLQ VSSGLNENLT VNGGGWNEKS VKLSSQISAG
       310        320        330        340        350        360
EEKWNSVSPA SAGKRKTEPS AWSQDTGDAN TNGKDWGRSW SDRSIFSGIG STAEPVSQST
       370        380        390        400        410        420
TSDYQWDVSR NQPYIDDEWS GLNGLSSADP NSDWNAPAEE WGNWVDEERA SLLKSQEPIP
       430        440        450        460        470        480
DDQKVSDDDK EKGEGALPTG KSKKKKKKKK KQGEDNSTAQ DTEELEKEIR EDLPVNTSKT
       490        500        510        520        530        540
RPKQEKAFSL KTISTSDPAE VLVKNSQPIK TLPPATSTEP SVILSKSDSD KSSSQVPPIL
       550        560        570        580
QETDKSKSNT KQNSVPPSQT KSETSWESPK QIKKKKKARR ET

Isoforms

Sequence View

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

15 N-termini - 4 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q86UE4-1-unknown	MAARSW...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q86UE4-24-unknown	MLSVGL...	24	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000428168
Q86UE4-102-unknown	DLALLK...	102	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12751
Q86UE4-184-	GKEVDE...	184		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q86UE4-294-unknown	SSQISA...	294		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q86UE4-294-	SSQISA...	294		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q86UE4-331-unknown	TNGKDW...	331	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000429642
Q86UE4-351-	STAEPV...	351		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q86UE4-384-	GLSSAD...	384		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q86UE4-384-	GLSSAD...	384		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q86UE4-384-	GLSSAD...	384		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q86UE4-387-	SADPNS...	387		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q86UE4-387-	SADPNS...	387		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q86UE4-457-	STAQDT...	457		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q86UE4-457-	STAQDT...	457		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q86UE4-487-	AFSLKT...	487		Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
Q86UE4-492-unknown	TISTSD...	492		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q86UE4-492-	TISTSD...	492		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q86UE4-492-	TISTSD...	492		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q86UE4-492-	TISTSD...	492		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q86UE4-505-	NSQPIK...	505		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...AAAPDD	101	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12751
...GRSWSD	341	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000428703
...KSETSW	565	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000429642
...ARRET	582	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	101	APDD.\|.DLAL	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)