Q8IY37: Probable ATP-dependent RNA helicase DHX37

General Information

Protein names	- Probable ATP-dependent RNA helicase DHX37 - 3.6.4.13 - DEAH box protein 37
Gene names	DHX37
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q8IY37

5 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MGKLRRRYNI KGRQQAGPGP SKGPPEPPPV QLELEDKDTL KGVDASNALV LPGKKKKKTK
        70         80         90        100        110        120
APPLSKKEKK PLTKKEKKVL QKILEQKEKK SQRAEMLQKL SEVQASEAEM RLFYTTSKLG
       130        140        150        160        170        180
TGNRMYHTKE KADEVVAPGQ EKISSLSGAH RKRRRWPSAE EEEEEEEESE SELEEESELD
       190        200        210        220        230        240
EDPAAEPAEA GVGTTVAPLP PAPAPSSQPV PAGMTVPPPP AAAPPLPRAL AKPAVFIPVN
       250        260        270        280        290        300
RSPEMQEERL KLPILSEEQV IMEAVAEHPI VIVCGETGSG KTTQVPQFLY EAGFSSEDSI
       310        320        330        340        350        360
IGVTEPRRVA AVAMSQRVAK EMNLSQRVVS YQIRYEGNVT EETRIKFMTD GVLLKEIQKD
       370        380        390        400        410        420
FLLLRYKVVI IDEAHERSVY TDILIGLLSR IVTLRAKRNL PLKLLIMSAT LRVEDFTQNP
       430        440        450        460        470        480
RLFAKPPPVI KVESRQFPVT VHFNKRTPLE DYSGECFRKV CKIHRMLPAG GILVFLTGQA
       490        500        510        520        530        540
EVHALCRRLR KAFPPSRARP QEKDDDQKDS VEEMRKFKKS RARAKKARAE VLPQINLDHY
       550        560        570        580        590        600
SVLPAGEGDE DREAEVDEEE GALDSDLDLD LGDGGQDGGE QPDASLPLHV LPLYSLLAPE
       610        620        630        640        650        660
KQAQVFKPPP EGTRLCVVAT NVAETSLTIP GIKYVVDCGK VKKRYYDRVT GVSSFRVTWV
       670        680        690        700        710        720
SQASADQRAG RAGRTEPGHC YRLYSSAVFG DFEQFPPPEI TRRPVEDLIL QMKALNVEKV
       730        740        750        760        770        780
INFPFPTPPS VEALLAAEEL LIALGALQPP QKAERVKQLQ ENRLSCPITA LGRTMATFPV
       790        800        810        820        830        840
APRYAKMLAL SRQHGCLPYA ITIVASMTVR ELFEELDRPA ASDEELTRLK SKRARVAQMK
       850        860        870        880        890        900
RTWAGQGASL KLGDLMVLLG AVGACEYASC TPQFCEANGL RYKAMMEIRR LRGQLTTAVN
       910        920        930        940        950        960
AVCPEAELFV DPKMQPPTES QVTYLRQIVT AGLGDHLARR VQSEEMLEDK WRNAYKTPLL
       970        980        990       1000       1010       1020
DDPVFIHPSS VLFKELPEFV VYQEIVETTK MYMKGVSSVE VQWIPALLPS YCQFDKPLEE
      1030       1040       1050       1060       1070       1080
PAPTYCPERG RVLCHRASVF YRVGWPLPAI EVDFPEGIDR YKHFARFLLE GQVFRKLASY
      1090       1100       1110       1120       1130       1140
RSCLLSSPGT MLKTWARLQP RTESLLRALV AEKADCHEAL LAAWKKNPKY LLAEYCEWLP
      1150
QAMHPDIEKA WPPTTVH

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

5 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q8IY37-1-unknown	MGKLRR...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q8IY37-73-unknown	TKKEKK...	73	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14728
Q8IY37-214-unknown	MTVPPP...	214	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000439009
Q8IY37-539-unknown	HYSVLP...	539	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12821
Q8IY37-574-	GGQDGG...	574		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q8IY37-574-	GGQDGG...	574		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...EKKPLT	72	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14728
...QINLDH	538	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12821
...PTTVH	1157	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	72	KPLT.\|.TKKE	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAB_HUMAN	538	NLDH.\|.HYSV	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)