Q8IY81: pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3 {ECO:0000255|HAMAP-Rule:MF_03163}

General Information

Protein names	- pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3 {ECO:0000255\|HAMAP-Rule:MF_03163} - 2.1.1.- {ECO:0000255\|HAMAP-Rule:MF_03163, ECO:0000269\|PubMed:30626973} - Protein ftsJ homolog 3 {ECO:0000255\|HAMAP-Rule:MF_03163} - Putative rRNA methyltransferase 3 {ECO:0000255\|HAMAP-Rule:MF_03163}
Gene names	FTSJ3
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q8IY81

12 N-termini

8 C-termini

4 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MGKKGKVGKS RRDKFYHLAK ETGYRSRSAF KLIQLNRRFQ FLQKARALLD LCAAPGGWLQ
        70         80         90        100        110        120
VAAKFMPVSS LIVGVDLVPI KPLPNVVTLQ QDITTERCRQ ALRKELKTWK VDVVLNDGAP
       130        140        150        160        170        180
NVGASWVHDA YSQAHLTLMA LRLACDFLAR GGSFITKVFR SRDYQPLLWI FQQLFRRVQA
       190        200        210        220        230        240
TKPQASRHES AEIFVVCQGF LAPDKVDSKF FDPKFAFKEV EVQAKTVTEL VTKKKPKAEG
       250        260        270        280        290        300
YAEGDLTLYH RTSVTDFLRA ANPVDFLSKA SEIMVDDEEL AQHPATTEDI RVCCQDIRVL
       310        320        330        340        350        360
GRKELRSLLN WRTKLRRYVA KKLKEQAKAL DISLSSGEED EGDEEDSTAG TTKQPSKEEE
       370        380        390        400        410        420
EEEEEEQLNQ TLAEMKAQEV AELKRKKKKL LREQRKQRER VELKMDLPGV SIADEGETGM
       430        440        450        460        470        480
FSLSTIRGHQ LLEEVTQGDM SAADTFLSDL PRDDIYVSDV EDDGDDTSLD SDLDPEELAG
       490        500        510        520        530        540
VRGHQGLRDQ KRMRLTEVQD DKEEEEEENP LLVPLEEKAV LQEEQANLWF SKGSFAGIED
       550        560        570        580        590        600
DADEALEISQ AQLLFENRRK GRQQQQKQQL PQTPPSCLKT EIMSPLYQDE APKGTEASSG
       610        620        630        640        650        660
TEAATGLEGE EKDGISDSDS STSSEEEESW EPLRGKKRSR GPKSDDDGFE IVPIEDPAKH
       670        680        690        700        710        720
RILDPEGLAL GAVIASSKKA KRDLIDNSFN RYTFNEDEGE LPEWFVQEEK QHRIRQLPVG
       730        740        750        760        770        780
KKEVEHYRKR WREINARPIK KVAEAKARKK RRMLKRLEQT RKKAEAVVNT VDISEREKVA
       790        800        810        820        830        840
QLRSLYKKAG LGKEKRHVTY VVAKKGVGRK VRRPAGVRGH FKVVDSRMKK DQRAQQRKEQ

KKKHKRK

Isoforms

Sequence View

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Physiological Relevance:

Evidence Codes:

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Protease Assignment Confidence:

Evidence Names:

Database:

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Protein Neighborhood

Domains & Features

12 N-termini - 8 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q8IY81-1-unknown	MGKKGK...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q8IY81-2-unknown	GKKGKV...	2		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q8IY81-2-unknown	GKKGKV...	2		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q8IY81-260-	AANPVD...	260		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q8IY81-260-	AANPVD...	260		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q8IY81-277-unknown	DEELAQ...	277	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12822
Q8IY81-347-	STAGTT...	347		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q8IY81-347-	STAGTT...	347		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q8IY81-441-	SAADTF...	441		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q8IY81-445-	TFLSDL...	445		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q8IY81-445-unknown	TFLSDL...	445	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12823
Q8IY81-495-	LTEVQD...	495		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q8IY81-542-unknown	ADEALE...	542	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12824
Q8IY81-552-unknown	QLLFEN...	552	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12825
Q8IY81-648-	GFEIVP...	648		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...AFKLIQ	33	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000464361
...VDVVLN	115	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000464648
...FLARGG	151	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000462290
...EIMVDD	276	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12822
...MSAADT	444	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12823
...GIEDDA	541	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12824
...EISQAQ	551	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12825
...KHKRK	847	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	276	MVDD.\|.DEEL	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAB_HUMAN	444	AADT.\|.TFLS	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAB_HUMAN	541	EDDA.\|.ADEA	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAB_HUMAN	551	SQAQ.\|.QLLF	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)