Q8IZ73: RNA pseudouridylate synthase domain-containing protein 2

General Information

Protein names	- RNA pseudouridylate synthase domain-containing protein 2
Gene names	RPUSD2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q8IZ73

3 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MWLDRRGWLR VLGHWRYDLR RPSFTRTWSG DKGPMAETVS TQVGTEGGLR ASHQQNGDAG
        70         80         90        100        110        120
GDAKVELSPG PPKPAGREVE PAPVGGEHPS AAAPGPGKHK KRRGATRERV VPPPKKRRTG
       130        140        150        160        170        180
VSFGDEHFAE TSYYFEGGLR KVRPYYFDFR TYCKGRWVGH SLLHVFSTEF RAQPLAYYEA
       190        200        210        220        230        240
AVRAGRLQLN EKPVQDLNIV LKDNDFLRNT VHRHEPPVTA EPIRLLAENE DVVVVDKPSS
       250        260        270        280        290        300
IPVHPCGRFR HNTVIFILGK EHQLKELHPL HRLDRLTSGV LMFAKTAAVS ERIHEQVRDR
       310        320        330        340        350        360
QLEKEYVCRV EGEFPTEEVT CKEPILVVSY KVGVCRVDPR GKPCETVFQR LSYNGQSSVV
       370        380        390        400        410        420
RCRPLTGRTH QIRVHLQFLG HPILNDPIYN SVAWGPSRGR GGYIPKTNEE LLRDLVAEHQ
       430        440        450        460        470        480
AKQSLDVLDL CEGDLSPGLT DSTAPSSELG KDDLEELAAA AQKMEEVAEA APQELDTIAL
       490        500        510        520        530        540
ASEKAVETDV MNQETDPLCA ECRLVRQDPL PQDLVMFLHA LRYKGPGFEY FSPMPAWAQD

DWQKD

Isoforms

- Isoform 2 of RNA pseudouridylate synthase domain-containing protein 2

Sequence View

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Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q8IZ73-1-unknown	MWLDRR...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q8IZ73-63-unknown	AKVELS...	63	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12831
Q8IZ73-442-	STAPSS...	442		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q8IZ73-442-	STAPSS...	442		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q8IZ73-442-	STAPSS...	442		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q8IZ73-442-	STAPSS...	442		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...DAGGDA	62	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12831
	...DWQKD	545	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	62	GGDA.\|.AKVE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)