Q8N108: Mesoderm induction early response protein 1

General Information

Protein names	- Mesoderm induction early response protein 1 - Early response 1 - Er1 - Mi-er1 - hMi-er1
Gene names	MIER1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q8N108

4 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAEPSVESSS PGGSATSDDH EFDPSADMLV HDFDDERTLE EEEMMEGETN FSSEIEDLAR
        70         80         90        100        110        120
EGDMPIHELL SLYGYGSTVR LPEEDEEEEE EEEEGEDDED ADNDDNSGCS GENKEENIKD
       130        140        150        160        170        180
SSGQEDETQS SNDDPSQSVA SQDAQEIIRP RRCKYFDTNS EVEEESEEDE DYIPSEDWKK
       190        200        210        220        230        240
EIMVGSMFQA EIPVGICRYK ENEKVYENDD QLLWDPEYLP EDKVIIFLKD ASRRTGDEKG
       250        260        270        280        290        300
VEAIPEGSHI KDNEQALYEL VKCNFDTEEA LRRLRFNVKA AREELSVWTE EECRNFEQGL
       310        320        330        340        350        360
KAYGKDFHLI QANKVRTRSV GECVAFYYMW KKSERYDFFA QQTRFGKKKY NLHPGVTDYM
       370        380        390        400        410        420
DRLLDESESA ASSRAPSPPP TASNSSNSQS EKEDGTVSTA NQNGVSSNGP GEILNKEEVK
       430        440        450        460        470        480
VEGLHINGPT GGNKKPLHAD MDTNGYETDN LTTDPKLAHM TARNENDFDE KSERPAKRRR
       490        500        510
VNSNGKESPG SSEFFQEAVS HGKFEELENT DD

Isoforms

- Isoform 2 of Mesoderm induction early response protein 1 - Isoform 3 of Mesoderm induction early response protein 1 - Isoform 4 of Mesoderm induction early response protein 1 - Isoform 5 of Mesoderm induction early response protein 1 - Isoform 6 of Mesoderm induction early response protein 1 - Isoform 7 of Mesoderm induction early response protein 1 - Isoform 8 of Mesoderm induction early response protein 1 - Isoform 9 of Mesoderm induction early response protein 1 - Isoform 10 of Mesoderm induction early response protein 1

Sequence View

        10         20         30         40         50         60
MAEPSVESSS PGGSATSDDH EFDPSADMLV HDFDDERTLE EEEMMEGETN FSSEIEDLAR
        70         80         90        100        110        120
EGDMPIHELL SLYGYGSTVR LPEEDEEEEE EEEEGEDDED ADNDDNSGCS GENKEENIKD
       130        140        150        160        170        180
SSGQEDETQS SNDDPSQSVA SQDAQEIIRP RRCKYFDTNS EVEEESEEDE DYIPSEDWKK
       190        200        210        220        230        240
EIMVGSMFQA EIPVGICRYK ENEKVYENDD QLLWDPEYLP EDKVIIFLKD ASRRTGDEKG
       250        260        270        280        290        300
VEAIPEGSHI KDNEQALYEL VKCNFDTEEA LRRLRFNVKA AREELSVWTE EECRNFEQGL
       310        320        330        340        350        360
KAYGKDFHLI QANKVRTRSV GECVAFYYMW KKSERYDFFA QQTRFGKKKY NLHPGVTDYM
       370        380        390        400        410        420
DRLLDESESA ASSRAPSPPP TASNSSNSQS EKEDGTVSTA NQNGVSSNGP GEILNKEEVK
       430        440        450        460        470        480
VEGLHINGPT GGNKKPLHAD MDTNGYETDN LTTDPKLAHM TARNENDFDE KSERPAKRRR
       490        500        510
VNSNGKESPG SSEFFQEAVS HGKFEELENT DD         10         20         30         40         50         60
MAEPSVESSS PGGSATSDDH EFDPSADMLV HDFDDERTLE EEEMMEGETN FSSEIEDLAR
        70         80         90        100        110        120
EGDMPIHELL SLYGYGSTVR LPEEDEEEEE EEEEGEDDED ADNDDNSGCS GENKEENIKD
       130        140        150        160        170        180
SSGQEDETQS SNDDPSQSVA SQDAQEIIRP RRCKYFDTNS EVEEESEEDE DYIPSEDWKK
       190        200        210        220        230        240
EIMVGSMFQA EIPVGICRYK ENEKVYENDD QLLWDPEYLP EDKVIIFLKD ASRRTGDEKG
       250        260        270        280        290        300
VEAIPEGSHI KDNEQALYEL VKCNFDTEEA LRRLRFNVKA AREELSVWTE EECRNFEQGL
       310        320        330        340        350        360
KAYGKDFHLI QANKVRTRSV GECVAFYYMW KKSERYDFFA QQTRFGKKKY NLHPGVTDYM
       370        380        390        400        410        420
DRLLDESESA ASSRAPSPPP TASNSSNSQS EKEDGTVSTA NQNGVSSNGP GEILNKEEVK
       430        440        450        460        470        480
VEGLHINGPT GGNKKPLHAD MDTNGYETDN LTTDPKLAHM TARNENDFDE KSERPAKRRR
       490        500        510
VNSNGKESPG SSEFFQEAVS HGKFEELENT DD         10         20         30         40         50         60
MAEPSVESSS PGGSATSDDH EFDPSADMLV HDFDDERTLE EEEMMEGETN FSSEIEDLAR
        70         80         90        100        110        120
EGDMPIHELL SLYGYGSTVR LPEEDEEEEE EEEEGEDDED ADNDDNSGCS GENKEENIKD
       130        140        150        160        170        180
SSGQEDETQS SNDDPSQSVA SQDAQEIIRP RRCKYFDTNS EVEEESEEDE DYIPSEDWKK
       190        200        210        220        230        240
EIMVGSMFQA EIPVGICRYK ENEKVYENDD QLLWDPEYLP EDKVIIFLKD ASRRTGDEKG
       250        260        270        280        290        300
VEAIPEGSHI KDNEQALYEL VKCNFDTEEA LRRLRFNVKA AREELSVWTE EECRNFEQGL
       310        320        330        340        350        360
KAYGKDFHLI QANKVRTRSV GECVAFYYMW KKSERYDFFA QQTRFGKKKY NLHPGVTDYM
       370        380        390        400        410        420
DRLLDESESA ASSRAPSPPP TASNSSNSQS EKEDGTVSTA NQNGVSSNGP GEILNKEEVK
       430        440        450        460        470        480
VEGLHINGPT GGNKKPLHAD MDTNGYETDN LTTDPKLAHM TARNENDFDE KSERPAKRRR
       490        500        510
VNSNGKESPG SSEFFQEAVS HGKFEELENT DD         10         20         30         40         50         60
MAEPSVESSS PGGSATSDDH EFDPSADMLV HDFDDERTLE EEEMMEGETN FSSEIEDLAR
        70         80         90        100        110        120
EGDMPIHELL SLYGYGSTVR LPEEDEEEEE EEEEGEDDED ADNDDNSGCS GENKEENIKD
       130        140        150        160        170        180
SSGQEDETQS SNDDPSQSVA SQDAQEIIRP RRCKYFDTNS EVEEESEEDE DYIPSEDWKK
       190        200        210        220        230        240
EIMVGSMFQA EIPVGICRYK ENEKVYENDD QLLWDPEYLP EDKVIIFLKD ASRRTGDEKG
       250        260        270        280        290        300
VEAIPEGSHI KDNEQALYEL VKCNFDTEEA LRRLRFNVKA AREELSVWTE EECRNFEQGL
       310        320        330        340        350        360
KAYGKDFHLI QANKVRTRSV GECVAFYYMW KKSERYDFFA QQTRFGKKKY NLHPGVTDYM
       370        380        390        400        410        420
DRLLDESESA ASSRAPSPPP TASNSSNSQS EKEDGTVSTA NQNGVSSNGP GEILNKEEVK
       430        440        450        460        470        480
VEGLHINGPT GGNKKPLHAD MDTNGYETDN LTTDPKLAHM TARNENDFDE KSERPAKRRR
       490        500        510
VNSNGKESPG SSEFFQEAVS HGKFEELENT DD         10         20         30         40         50         60
MAEPSVESSS PGGSATSDDH EFDPSADMLV HDFDDERTLE EEEMMEGETN FSSEIEDLAR
        70         80         90        100        110        120
EGDMPIHELL SLYGYGSTVR LPEEDEEEEE EEEEGEDDED ADNDDNSGCS GENKEENIKD
       130        140        150        160        170        180
SSGQEDETQS SNDDPSQSVA SQDAQEIIRP RRCKYFDTNS EVEEESEEDE DYIPSEDWKK
       190        200        210        220        230        240
EIMVGSMFQA EIPVGICRYK ENEKVYENDD QLLWDPEYLP EDKVIIFLKD ASRRTGDEKG
       250        260        270        280        290        300
VEAIPEGSHI KDNEQALYEL VKCNFDTEEA LRRLRFNVKA AREELSVWTE EECRNFEQGL
       310        320        330        340        350        360
KAYGKDFHLI QANKVRTRSV GECVAFYYMW KKSERYDFFA QQTRFGKKKY NLHPGVTDYM
       370        380        390        400        410        420
DRLLDESESA ASSRAPSPPP TASNSSNSQS EKEDGTVSTA NQNGVSSNGP GEILNKEEVK
       430        440        450        460        470        480
VEGLHINGPT GGNKKPLHAD MDTNGYETDN LTTDPKLAHM TARNENDFDE KSERPAKRRR
       490        500        510
VNSNGKESPG SSEFFQEAVS HGKFEELENT DD         10         20         30         40         50         60
MAEPSVESSS PGGSATSDDH EFDPSADMLV HDFDDERTLE EEEMMEGETN FSSEIEDLAR
        70         80         90        100        110        120
EGDMPIHELL SLYGYGSTVR LPEEDEEEEE EEEEGEDDED ADNDDNSGCS GENKEENIKD
       130        140        150        160        170        180
SSGQEDETQS SNDDPSQSVA SQDAQEIIRP RRCKYFDTNS EVEEESEEDE DYIPSEDWKK
       190        200        210        220        230        240
EIMVGSMFQA EIPVGICRYK ENEKVYENDD QLLWDPEYLP EDKVIIFLKD ASRRTGDEKG
       250        260        270        280        290        300
VEAIPEGSHI KDNEQALYEL VKCNFDTEEA LRRLRFNVKA AREELSVWTE EECRNFEQGL
       310        320        330        340        350        360
KAYGKDFHLI QANKVRTRSV GECVAFYYMW KKSERYDFFA QQTRFGKKKY NLHPGVTDYM
       370        380        390        400        410        420
DRLLDESESA ASSRAPSPPP TASNSSNSQS EKEDGTVSTA NQNGVSSNGP GEILNKEEVK
       430        440        450        460        470        480
VEGLHINGPT GGNKKPLHAD MDTNGYETDN LTTDPKLAHM TARNENDFDE KSERPAKRRR
       490        500        510
VNSNGKESPG SSEFFQEAVS HGKFEELENT DD         10         20         30         40         50         60
MAEPSVESSS PGGSATSDDH EFDPSADMLV HDFDDERTLE EEEMMEGETN FSSEIEDLAR
        70         80         90        100        110        120
EGDMPIHELL SLYGYGSTVR LPEEDEEEEE EEEEGEDDED ADNDDNSGCS GENKEENIKD
       130        140        150        160        170        180
SSGQEDETQS SNDDPSQSVA SQDAQEIIRP RRCKYFDTNS EVEEESEEDE DYIPSEDWKK
       190        200        210        220        230        240
EIMVGSMFQA EIPVGICRYK ENEKVYENDD QLLWDPEYLP EDKVIIFLKD ASRRTGDEKG
       250        260        270        280        290        300
VEAIPEGSHI KDNEQALYEL VKCNFDTEEA LRRLRFNVKA AREELSVWTE EECRNFEQGL
       310        320        330        340        350        360
KAYGKDFHLI QANKVRTRSV GECVAFYYMW KKSERYDFFA QQTRFGKKKY NLHPGVTDYM
       370        380        390        400        410        420
DRLLDESESA ASSRAPSPPP TASNSSNSQS EKEDGTVSTA NQNGVSSNGP GEILNKEEVK
       430        440        450        460        470        480
VEGLHINGPT GGNKKPLHAD MDTNGYETDN LTTDPKLAHM TARNENDFDE KSERPAKRRR
       490        500        510
VNSNGKESPG SSEFFQEAVS HGKFEELENT DD         10         20         30         40         50         60
MAEPSVESSS PGGSATSDDH EFDPSADMLV HDFDDERTLE EEEMMEGETN FSSEIEDLAR
        70         80         90        100        110        120
EGDMPIHELL SLYGYGSTVR LPEEDEEEEE EEEEGEDDED ADNDDNSGCS GENKEENIKD
       130        140        150        160        170        180
SSGQEDETQS SNDDPSQSVA SQDAQEIIRP RRCKYFDTNS EVEEESEEDE DYIPSEDWKK
       190        200        210        220        230        240
EIMVGSMFQA EIPVGICRYK ENEKVYENDD QLLWDPEYLP EDKVIIFLKD ASRRTGDEKG
       250        260        270        280        290        300
VEAIPEGSHI KDNEQALYEL VKCNFDTEEA LRRLRFNVKA AREELSVWTE EECRNFEQGL
       310        320        330        340        350        360
KAYGKDFHLI QANKVRTRSV GECVAFYYMW KKSERYDFFA QQTRFGKKKY NLHPGVTDYM
       370        380        390        400        410        420
DRLLDESESA ASSRAPSPPP TASNSSNSQS EKEDGTVSTA NQNGVSSNGP GEILNKEEVK
       430        440        450        460        470        480
VEGLHINGPT GGNKKPLHAD MDTNGYETDN LTTDPKLAHM TARNENDFDE KSERPAKRRR
       490        500        510
VNSNGKESPG SSEFFQEAVS HGKFEELENT DD         10         20         30         40         50         60
MAEPSVESSS PGGSATSDDH EFDPSADMLV HDFDDERTLE EEEMMEGETN FSSEIEDLAR
        70         80         90        100        110        120
EGDMPIHELL SLYGYGSTVR LPEEDEEEEE EEEEGEDDED ADNDDNSGCS GENKEENIKD
       130        140        150        160        170        180
SSGQEDETQS SNDDPSQSVA SQDAQEIIRP RRCKYFDTNS EVEEESEEDE DYIPSEDWKK
       190        200        210        220        230        240
EIMVGSMFQA EIPVGICRYK ENEKVYENDD QLLWDPEYLP EDKVIIFLKD ASRRTGDEKG
       250        260        270        280        290        300
VEAIPEGSHI KDNEQALYEL VKCNFDTEEA LRRLRFNVKA AREELSVWTE EECRNFEQGL
       310        320        330        340        350        360
KAYGKDFHLI QANKVRTRSV GECVAFYYMW KKSERYDFFA QQTRFGKKKY NLHPGVTDYM
       370        380        390        400        410        420
DRLLDESESA ASSRAPSPPP TASNSSNSQS EKEDGTVSTA NQNGVSSNGP GEILNKEEVK
       430        440        450        460        470        480
VEGLHINGPT GGNKKPLHAD MDTNGYETDN LTTDPKLAHM TARNENDFDE KSERPAKRRR
       490        500        510
VNSNGKESPG SSEFFQEAVS HGKFEELENT DD

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q8N108-1-unknown	MAEPSV...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q8N108-28-	MLVHDF...	28		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q8N108-49-unknown	TNFSSE...	49	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12845
Q8N108-71-unknown	SLYGYG...	71	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14736

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...MMEGET	48	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12845
...IHELLS	70	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14736
...ENTDD	512	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	48	EGET.\|.TNFS	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAM_HUMAN	70	ELLS.\|.SLYG	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

TopFIND

Q8N108: Mesoderm induction early response protein 1

General Information

4

N-termini

3

C-termini

2

Cleavages

0

Substrates

Sequence

Isoforms

Filter Information:

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

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Protein Neighborhood

Domains & Features

4 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates