Q8N1G4: Leucine-rich repeat-containing protein 47

General Information

Protein names	- Leucine-rich repeat-containing protein 47
Gene names	LRRC47
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q8N1G4

6 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAAAAVSESW PELELAERER RRELLLTGPG LEERVRAAGG QLPPRLFTLP LLHYLEVSGC
        70         80         90        100        110        120
GSLRAPGPGL AQGLPQLHSL VLRRNALGPG LSPELGPLPA LRVLDLSGNA LEALPPGQGL
       130        140        150        160        170        180
GPAEPPGLPQ LQSLNLSGNR LRELPADLAR CAPRLQSLNL TGNCLDSFPA ELFRPGALPL
       190        200        210        220        230        240
LSELAAADNC LRELSPDIAH LASLKTLDLS NNQLSEIPAE LADCPKLKEI NFRGNKLRDK
       250        260        270        280        290        300
RLEKMVSGCQ TRSILEYLRV GGRGGGKGKG RAEGSEKEES RRKRRERKQR REGGDGEEQD
       310        320        330        340        350        360
VGDAGRLLLR VLHVSENPVP LTVRVSPEVR DVRPYIVGAV VRGMDLQPGN ALKRFLTSQT
       370        380        390        400        410        420
KLHEDLCEKR TAATLATHEL RAVKGPLLYC ARPPQDLKIV PLGRKEAKAK ELVRQLQLEA
       430        440        450        460        470        480
EEQRKQKKRQ SVSGLHRYLH LLDGNENYPC LVDADGDVIS FPPITNSEKT KVKKTTSDLF
       490        500        510        520        530        540
LEVTSATSLQ ICKDVMDALI LKMAEMKKYT LENKEEGSLS DTEADAVSGQ LPDPTTNPSA
       550        560        570        580
GKDGPSLLVV EQVRVVDLEG SLKVVYPSKA DLATAPPHVT VVR

Isoforms

Sequence View

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Directness:

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Evidence Codes:

Methodology:

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Protease Assignment Confidence:

Evidence Names:

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Lab:

Protein Neighborhood

Domains & Features

6 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q8N1G4-2-unknown	MAAAAV...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q8N1G4-2-Acetylation	AAAAVS...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q8N1G4-2-Acetylation	AAAAVS...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
Q8N1G4-2-Acetylation	AAAAVS...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q8N1G4-526-unknown	AVSGQL...	526		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1323
Q8N1G4-526-unknown	AVSGQL...	526			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q8N1G4-526-	AVSGQL...	526			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
Q8N1G4-526-	AVSGQL...	526			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q8N1G4-526-	AVSGQL...	526			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q8N1G4-526-	AVSGQL...	526			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_CD95	23264352
Q8N1G4-526-	AVSGQL...	526			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q8N1G4-526-	AVSGQL...	526			Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
Q8N1G4-526-	AVSGQL...	526			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q8N1G4-526-	AVSGQL...	526			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q8N1G4-526-	AVSGQL...	526			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q8N1G4-526-	AVSGQL...	526			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q8N1G4-526-	AVSGQL...	526			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q8N1G4-526-	AVSGQL...	526			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
Q8N1G4-526-	AVSGQL...	526			Subtiligase Based Positive Selection		Wells	RMPI_untreated	23264352
Q8N1G4-526-	AVSGQL...	526			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q8N1G4-536-unknown	TNPSAG...	536		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14746
Q8N1G4-564-	VVYPSK...	564			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...DTEADA	525	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1323
...LPDPTT	535	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14746
...VTVVR	583	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP1_HUMAN	525	EADA.\|.AVSG	inferred from experiment	unknown	MEROPS	Wells JA	Agard NJ et al.:Inflammatory stimuli regulate c... (C14.001)	20173201,
GRAM_HUMAN	535	DPTT.\|.TNPS	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)