Q8N257: Histone H2B type 3-B

General Information

Protein names	- Histone H2B type 3-B - H2B type 12
Gene names	HIST3H2BB
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q8N257

7 N-termini

5 C-termini

4 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MPDPSKSAPA PKKGSKKAVT KAQKKDGKKR KRGRKESYSI YVYKVLKQVH PDTGISSKAM
        70         80         90        100        110        120
GIMNSFVNDI FERIASEASR LAHYNKRSTI TSREVQTAVR LLLPGELAKH AVSEGTKAVT

KYTSSK

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

7 N-termini - 5 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q8N257-2-unknown	MPDPSK...	1		inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
Q8N257-2-unknown	MPDPSK...	1			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q8N257-2-unknown	MPDPSK...	1			COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q8N257-2-unknown	MPDPSK...	1			COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q8N257-2-unknown	MPDPSK...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q8N257-2-Acetylation	PDPSKS...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q8N257-2-Acetylation	PDPSKS...	2	acetylation-	inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
Q8N257-2-	PDPSKS...	2			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q8N257-6-unknown	KSAPAP...	6		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14747
Q8N257-22-unknown	AQKKDG...	22		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10424
Q8N257-53-unknown	TGISSK...	53		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12858
Q8N257-59-unknown	AMGIMN...	59		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10425

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...MPDPSK	5	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14747
...KAVTKA	21	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10424
...QVHPDT	52	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12858
...GISSKA	58	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10425
...YTSSK	126	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	5	DPSK.\|.KSAP	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAA_HUMAN	21	VTKA.\|.AQKK	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
GRAB_HUMAN	52	HPDT.\|.TGIS	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
GRAA_HUMAN	58	SSKA.\|.AMGI	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)