Q8NEF9: Serum response factor-binding protein 1

General Information

Protein names	- Serum response factor-binding protein 1 - SRF-dependent transcription regulation-associated protein - p49/STRAP
Gene names	SRFBP1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q8NEF9

4 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAQPGTLNLN NEVVKMRKEV KRIRVLVIRK LVRSVGRLKS KKGTEDALLK NQRRAQRLLE
        70         80         90        100        110        120
EIHAMKELKP DIVTKSALGD DINFEKIFKK PDSTATERAI ARLAVHPLLK KKIDVLKAAV
       130        140        150        160        170        180
QAFKEARQNV AEVESSKNAS EDNHSENTLY SNDNGSNLQR EATVISEQKV KETKILAKKP
       190        200        210        220        230        240
IHNSKEKIAK MEHGPKAVTI ANSPSKPSEK DSVVSLESQK TPADPKLKTL SQTKKNKGSD
       250        260        270        280        290        300
SSLSGNSDGG EEFCEEEKEY FDDSTEERFY KQSSMSEDSD SGDDFFIGKV RRTRKKESSC
       310        320        330        340        350        360
HSSVKEQKPL EKVFLKEDTG ETHGDTRNDK IKPSTETRKL ESVFFHSLSG SKSSRRNFKE
       370        380        390        400        410        420
QAPKTRSLDF PQNEPQIKNQ FNKKLSGRLE NTKQQLQLPL HPSWEASRRR KEQQSNIAVF

QGKKITFDD

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q8NEF9-2-unknown	MAQPGT...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q8NEF9-2-Acetylation	AQPGTL...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q8NEF9-2-Acetylation	AQPGTL...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q8NEF9-2-Acetylation	AQPGTL...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q8NEF9-212-	SVVSLE...	212			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q8NEF9-212-	SVVSLE...	212			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q8NEF9-212-	SVVSLE...	212			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q8NEF9-212-	SVVSLE...	212			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
Q8NEF9-316-unknown	KEDTGE...	316		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14773

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...EKVFLK	315	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14773
	...ITFDD	429	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	315	VFLK.\|.KEDT	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)