Q8TEU7: Rap guanine nucleotide exchange factor 6

General Information

Protein names	- Rap guanine nucleotide exchange factor 6 - PDZ domain-containing guanine nucleotide exchange factor 2 - PDZ-GEF2 - RA-GEF-2
Gene names	RAPGEF6
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q8TEU7

8 N-termini

4 C-termini

2 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Rap guanine nucleotide exchange factor 6 - Isoform 3 of Rap guanine nucleotide exchange factor 6 - Isoform 4 of Rap guanine nucleotide exchange factor 6 - Isoform 5 of Rap guanine nucleotide exchange factor 6 - Isoform 6 of Rap guanine nucleotide exchange factor 6

Sequence View

        10         20         30         40         50         60
MNSPVDPGAR QALRKKPPER TPEDLNTIYS YLHGMEILSN LREHQLRLMS ARARYERYSG
        70         80         90        100        110        120
NQVLFCSETI ARCWYILLSG SVLVKGSMVL PPCSFGKQFG GKRGCDCLVL EPSEMIVVEN
       130        140        150        160        170        180
AKDNEDSILQ REIPARQSRR RFRKINYKGE RQTITDDVEV NSYLSLPADL TKMHLTENPH
       190        200        210        220        230        240
PQVTHVSSSQ SGCSIASDSG SSSLSDIYQA TESEVGDVDL TRLPEGPVDS EDDEEEDEEI
       250        260        270        280        290        300
DRTDPLQGRD LVRECLEKEP ADKTDDDIEQ LLEFMHQLPA FANMTMSVRR ELCSVMIFEV
       310        320        330        340        350        360
VEQAGAIILE DGQELDSWYV ILNGTVEISH PDGKVENLFM GNSFGITPTL DKQYMHGIVR
       370        380        390        400        410        420
TKVDDCQFVC IAQQDYWRIL NHVEKNTHKV EEEGEIVMVH EHRELDRSGT RKGHIVIKAT
       430        440        450        460        470        480
PERLIMHLIE EHSIVDPTYI EDFLLTYRTF LESPLDVGIK LLEWFKIDSL RDKVTRIVLL
       490        500        510        520        530        540
WVNNHFNDFE GDPAMTRFLE EFEKNLEDTK MNGHLRLLNI ACAAKAKWRQ VVLQKASRES
       550        560        570        580        590        600
PLQFSLNGGS EKGFGIFVEG VEPGSKAADS GLKRGDQIME VNGQNFENIT FMKAVEILRN
       610        620        630        640        650        660
NTHLALTVKT NIFVFKELLF RTEQEKSGVP HIPKIAEKKS NRHSIQHVPG DIEQTSQEKG
       670        680        690        700        710        720
SKKVKANTVS GGRNKIRKIL DKTRFSILPP KLFSDGGLSQ SQDDSIVGTR HCRHSLAIMP
       730        740        750        760        770        780
IPGTLSSSSP DLLQPTTSML DFSNPSDIPD QVIRVFKVDQ QSCYIIISKD TTAKEVVFHA
       790        800        810        820        830        840
VHEFGLTGAS DTYSLCEVSV TPEGVIKQRR LPDQFSKLAD RIQLNGRYYL KNNMETETLC
       850        860        870        880        890        900
SDEDAQELVK ESQLSMLQLS TIEVATQLSM RDFDLFRNIE PTEYIDDLFK LNSKTGNTHL
       910        920        930        940        950        960
KRFEDIVNQE TFWVASEILT EANQLKRMKI IKHFIKIALH CRECKNFNSM FAIISGLNLA
       970        980        990       1000       1010       1020
SVARLRGTWE KLPSKYEKHL QDLQDIFDPS RNMAKYRNIL SSQSMQPPII PLFPVVKKDM
      1030       1040       1050       1060       1070       1080
TFLHEGNDSK VDGLVNFEKL RMISKEIRQV VRMTSANMDP AMMFRQRSLS QGSTNSNMLD
      1090       1100       1110       1120       1130       1140
VQGGAHKKRA RRSSLLNAKK LYEDAQMARK VKQYLSSLDV ETDEEKFQMM SLQWEPAYGT
      1150       1160       1170       1180       1190       1200
LTKNLSEKRS AKSSEMSPVP MRSAGQTTKA HLHQPHRVSQ VLQVPAVNLH PIRKKGQTKD
      1210       1220       1230       1240       1250       1260
PALNTSLPQK VLGTTEEISG KKHTEDTISV ASSLHSSPPA SPQGSPHKGY TLIPSAKSDN
      1270       1280       1290       1300       1310       1320
LSDSSHSEIS SRSSIVSNCS VDSMSAALQD ERCSSQALAV PESTGALEKT EHASGIGDHS
      1330       1340       1350       1360       1370       1380
QHGPGWTLLK PSLIKCLAVS SSVSNEEISQ EHIIIEAADS GRGSWTSCSS SSHDNFQSLP
      1390       1400       1410       1420       1430       1440
NPKSWDFLNS YRHTHLDDPI AEVEPTDSEP YSCSKSCSRT CGQCKGSLER KSWTSSSSLS
      1450       1460       1470       1480       1490       1500
DTYEPNYGTV KQRVLESTPA ESSEGLDPKD ATDPVYKTVT SSTEKGLIVY CVTSPKKDDR
      1510       1520       1530       1540       1550       1560
YREPPPTPPG YLGISLADLK EGPHTHLKPP DYSVAVQRSK MMHNSLSRLP PASLSSNLVA
      1570       1580       1590       1600
CVPSKIVTQP QRHNLQPFHP KLGDVTDADS EADENEQVSA V         10         20         30         40         50         60
MNSPVDPGAR QALRKKPPER TPEDLNTIYS YLHGMEILSN LREHQLRLMS ARARYERYSG
        70         80         90        100        110        120
NQVLFCSETI ARCWYILLSG SVLVKGSMVL PPCSFGKQFG GKRGCDCLVL EPSEMIVVEN
       130        140        150        160        170        180
AKDNEDSILQ REIPARQSRR RFRKINYKGE RQTITDDVEV NSYLSLPADL TKMHLTENPH
       190        200        210        220        230        240
PQVTHVSSSQ SGCSIASDSG SSSLSDIYQA TESEVGDVDL TRLPEGPVDS EDDEEEDEEI
       250        260        270        280        290        300
DRTDPLQGRD LVRECLEKEP ADKTDDDIEQ LLEFMHQLPA FANMTMSVRR ELCSVMIFEV
       310        320        330        340        350        360
VEQAGAIILE DGQELDSWYV ILNGTVEISH PDGKVENLFM GNSFGITPTL DKQYMHGIVR
       370        380        390        400        410        420
TKVDDCQFVC IAQQDYWRIL NHVEKNTHKV EEEGEIVMVH EHRELDRSGT RKGHIVIKAT
       430        440        450        460        470        480
PERLIMHLIE EHSIVDPTYI EDFLLTYRTF LESPLDVGIK LLEWFKIDSL RDKVTRIVLL
       490        500        510        520        530        540
WVNNHFNDFE GDPAMTRFLE EFEKNLEDTK MNGHLRLLNI ACAAKAKWRQ VVLQKASRES
       550        560        570        580        590        600
PLQFSLNGGS EKGFGIFVEG VEPGSKAADS GLKRGDQIME VNGQNFENIT FMKAVEILRN
       610        620        630        640        650        660
NTHLALTVKT NIFVFKELLF RTEQEKSGVP HIPKIAEKKS NRHSIQHVPG DIEQTSQEKG
       670        680        690        700        710        720
SKKVKANTVS GGRNKIRKIL DKTRFSILPP KLFSDGGLSQ SQDDSIVGTR HCRHSLAIMP
       730        740        750        760        770        780
IPGTLSSSSP DLLQPTTSML DFSNPSDIPD QVIRVFKVDQ QSCYIIISKD TTAKEVVFHA
       790        800        810        820        830        840
VHEFGLTGAS DTYSLCEVSV TPEGVIKQRR LPDQFSKLAD RIQLNGRYYL KNNMETETLC
       850        860        870        880        890        900
SDEDAQELVK ESQLSMLQLS TIEVATQLSM RDFDLFRNIE PTEYIDDLFK LNSKTGNTHL
       910        920        930        940        950        960
KRFEDIVNQE TFWVASEILT EANQLKRMKI IKHFIKIALH CRECKNFNSM FAIISGLNLA
       970        980        990       1000       1010       1020
SVARLRGTWE KLPSKYEKHL QDLQDIFDPS RNMAKYRNIL SSQSMQPPII PLFPVVKKDM
      1030       1040       1050       1060       1070       1080
TFLHEGNDSK VDGLVNFEKL RMISKEIRQV VRMTSANMDP AMMFRQRSLS QGSTNSNMLD
      1090       1100       1110       1120       1130       1140
VQGGAHKKRA RRSSLLNAKK LYEDAQMARK VKQYLSSLDV ETDEEKFQMM SLQWEPAYGT
      1150       1160       1170       1180       1190       1200
LTKNLSEKRS AKSSEMSPVP MRSAGQTTKA HLHQPHRVSQ VLQVPAVNLH PIRKKGQTKD
      1210       1220       1230       1240       1250       1260
PALNTSLPQK VLGTTEEISG KKHTEDTISV ASSLHSSPPA SPQGSPHKGY TLIPSAKSDN
      1270       1280       1290       1300       1310       1320
LSDSSHSEIS SRSSIVSNCS VDSMSAALQD ERCSSQALAV PESTGALEKT EHASGIGDHS
      1330       1340       1350       1360       1370       1380
QHGPGWTLLK PSLIKCLAVS SSVSNEEISQ EHIIIEAADS GRGSWTSCSS SSHDNFQSLP
      1390       1400       1410       1420       1430       1440
NPKSWDFLNS YRHTHLDDPI AEVEPTDSEP YSCSKSCSRT CGQCKGSLER KSWTSSSSLS
      1450       1460       1470       1480       1490       1500
DTYEPNYGTV KQRVLESTPA ESSEGLDPKD ATDPVYKTVT SSTEKGLIVY CVTSPKKDDR
      1510       1520       1530       1540       1550       1560
YREPPPTPPG YLGISLADLK EGPHTHLKPP DYSVAVQRSK MMHNSLSRLP PASLSSNLVA
      1570       1580       1590       1600
CVPSKIVTQP QRHNLQPFHP KLGDVTDADS EADENEQVSA V         10         20         30         40         50         60
MNSPVDPGAR QALRKKPPER TPEDLNTIYS YLHGMEILSN LREHQLRLMS ARARYERYSG
        70         80         90        100        110        120
NQVLFCSETI ARCWYILLSG SVLVKGSMVL PPCSFGKQFG GKRGCDCLVL EPSEMIVVEN
       130        140        150        160        170        180
AKDNEDSILQ REIPARQSRR RFRKINYKGE RQTITDDVEV NSYLSLPADL TKMHLTENPH
       190        200        210        220        230        240
PQVTHVSSSQ SGCSIASDSG SSSLSDIYQA TESEVGDVDL TRLPEGPVDS EDDEEEDEEI
       250        260        270        280        290        300
DRTDPLQGRD LVRECLEKEP ADKTDDDIEQ LLEFMHQLPA FANMTMSVRR ELCSVMIFEV
       310        320        330        340        350        360
VEQAGAIILE DGQELDSWYV ILNGTVEISH PDGKVENLFM GNSFGITPTL DKQYMHGIVR
       370        380        390        400        410        420
TKVDDCQFVC IAQQDYWRIL NHVEKNTHKV EEEGEIVMVH EHRELDRSGT RKGHIVIKAT
       430        440        450        460        470        480
PERLIMHLIE EHSIVDPTYI EDFLLTYRTF LESPLDVGIK LLEWFKIDSL RDKVTRIVLL
       490        500        510        520        530        540
WVNNHFNDFE GDPAMTRFLE EFEKNLEDTK MNGHLRLLNI ACAAKAKWRQ VVLQKASRES
       550        560        570        580        590        600
PLQFSLNGGS EKGFGIFVEG VEPGSKAADS GLKRGDQIME VNGQNFENIT FMKAVEILRN
       610        620        630        640        650        660
NTHLALTVKT NIFVFKELLF RTEQEKSGVP HIPKIAEKKS NRHSIQHVPG DIEQTSQEKG
       670        680        690        700        710        720
SKKVKANTVS GGRNKIRKIL DKTRFSILPP KLFSDGGLSQ SQDDSIVGTR HCRHSLAIMP
       730        740        750        760        770        780
IPGTLSSSSP DLLQPTTSML DFSNPSDIPD QVIRVFKVDQ QSCYIIISKD TTAKEVVFHA
       790        800        810        820        830        840
VHEFGLTGAS DTYSLCEVSV TPEGVIKQRR LPDQFSKLAD RIQLNGRYYL KNNMETETLC
       850        860        870        880        890        900
SDEDAQELVK ESQLSMLQLS TIEVATQLSM RDFDLFRNIE PTEYIDDLFK LNSKTGNTHL
       910        920        930        940        950        960
KRFEDIVNQE TFWVASEILT EANQLKRMKI IKHFIKIALH CRECKNFNSM FAIISGLNLA
       970        980        990       1000       1010       1020
SVARLRGTWE KLPSKYEKHL QDLQDIFDPS RNMAKYRNIL SSQSMQPPII PLFPVVKKDM
      1030       1040       1050       1060       1070       1080
TFLHEGNDSK VDGLVNFEKL RMISKEIRQV VRMTSANMDP AMMFRQRSLS QGSTNSNMLD
      1090       1100       1110       1120       1130       1140
VQGGAHKKRA RRSSLLNAKK LYEDAQMARK VKQYLSSLDV ETDEEKFQMM SLQWEPAYGT
      1150       1160       1170       1180       1190       1200
LTKNLSEKRS AKSSEMSPVP MRSAGQTTKA HLHQPHRVSQ VLQVPAVNLH PIRKKGQTKD
      1210       1220       1230       1240       1250       1260
PALNTSLPQK VLGTTEEISG KKHTEDTISV ASSLHSSPPA SPQGSPHKGY TLIPSAKSDN
      1270       1280       1290       1300       1310       1320
LSDSSHSEIS SRSSIVSNCS VDSMSAALQD ERCSSQALAV PESTGALEKT EHASGIGDHS
      1330       1340       1350       1360       1370       1380
QHGPGWTLLK PSLIKCLAVS SSVSNEEISQ EHIIIEAADS GRGSWTSCSS SSHDNFQSLP
      1390       1400       1410       1420       1430       1440
NPKSWDFLNS YRHTHLDDPI AEVEPTDSEP YSCSKSCSRT CGQCKGSLER KSWTSSSSLS
      1450       1460       1470       1480       1490       1500
DTYEPNYGTV KQRVLESTPA ESSEGLDPKD ATDPVYKTVT SSTEKGLIVY CVTSPKKDDR
      1510       1520       1530       1540       1550       1560
YREPPPTPPG YLGISLADLK EGPHTHLKPP DYSVAVQRSK MMHNSLSRLP PASLSSNLVA
      1570       1580       1590       1600
CVPSKIVTQP QRHNLQPFHP KLGDVTDADS EADENEQVSA V         10         20         30         40         50         60
MNSPVDPGAR QALRKKPPER TPEDLNTIYS YLHGMEILSN LREHQLRLMS ARARYERYSG
        70         80         90        100        110        120
NQVLFCSETI ARCWYILLSG SVLVKGSMVL PPCSFGKQFG GKRGCDCLVL EPSEMIVVEN
       130        140        150        160        170        180
AKDNEDSILQ REIPARQSRR RFRKINYKGE RQTITDDVEV NSYLSLPADL TKMHLTENPH
       190        200        210        220        230        240
PQVTHVSSSQ SGCSIASDSG SSSLSDIYQA TESEVGDVDL TRLPEGPVDS EDDEEEDEEI
       250        260        270        280        290        300
DRTDPLQGRD LVRECLEKEP ADKTDDDIEQ LLEFMHQLPA FANMTMSVRR ELCSVMIFEV
       310        320        330        340        350        360
VEQAGAIILE DGQELDSWYV ILNGTVEISH PDGKVENLFM GNSFGITPTL DKQYMHGIVR
       370        380        390        400        410        420
TKVDDCQFVC IAQQDYWRIL NHVEKNTHKV EEEGEIVMVH EHRELDRSGT RKGHIVIKAT
       430        440        450        460        470        480
PERLIMHLIE EHSIVDPTYI EDFLLTYRTF LESPLDVGIK LLEWFKIDSL RDKVTRIVLL
       490        500        510        520        530        540
WVNNHFNDFE GDPAMTRFLE EFEKNLEDTK MNGHLRLLNI ACAAKAKWRQ VVLQKASRES
       550        560        570        580        590        600
PLQFSLNGGS EKGFGIFVEG VEPGSKAADS GLKRGDQIME VNGQNFENIT FMKAVEILRN
       610        620        630        640        650        660
NTHLALTVKT NIFVFKELLF RTEQEKSGVP HIPKIAEKKS NRHSIQHVPG DIEQTSQEKG
       670        680        690        700        710        720
SKKVKANTVS GGRNKIRKIL DKTRFSILPP KLFSDGGLSQ SQDDSIVGTR HCRHSLAIMP
       730        740        750        760        770        780
IPGTLSSSSP DLLQPTTSML DFSNPSDIPD QVIRVFKVDQ QSCYIIISKD TTAKEVVFHA
       790        800        810        820        830        840
VHEFGLTGAS DTYSLCEVSV TPEGVIKQRR LPDQFSKLAD RIQLNGRYYL KNNMETETLC
       850        860        870        880        890        900
SDEDAQELVK ESQLSMLQLS TIEVATQLSM RDFDLFRNIE PTEYIDDLFK LNSKTGNTHL
       910        920        930        940        950        960
KRFEDIVNQE TFWVASEILT EANQLKRMKI IKHFIKIALH CRECKNFNSM FAIISGLNLA
       970        980        990       1000       1010       1020
SVARLRGTWE KLPSKYEKHL QDLQDIFDPS RNMAKYRNIL SSQSMQPPII PLFPVVKKDM
      1030       1040       1050       1060       1070       1080
TFLHEGNDSK VDGLVNFEKL RMISKEIRQV VRMTSANMDP AMMFRQRSLS QGSTNSNMLD
      1090       1100       1110       1120       1130       1140
VQGGAHKKRA RRSSLLNAKK LYEDAQMARK VKQYLSSLDV ETDEEKFQMM SLQWEPAYGT
      1150       1160       1170       1180       1190       1200
LTKNLSEKRS AKSSEMSPVP MRSAGQTTKA HLHQPHRVSQ VLQVPAVNLH PIRKKGQTKD
      1210       1220       1230       1240       1250       1260
PALNTSLPQK VLGTTEEISG KKHTEDTISV ASSLHSSPPA SPQGSPHKGY TLIPSAKSDN
      1270       1280       1290       1300       1310       1320
LSDSSHSEIS SRSSIVSNCS VDSMSAALQD ERCSSQALAV PESTGALEKT EHASGIGDHS
      1330       1340       1350       1360       1370       1380
QHGPGWTLLK PSLIKCLAVS SSVSNEEISQ EHIIIEAADS GRGSWTSCSS SSHDNFQSLP
      1390       1400       1410       1420       1430       1440
NPKSWDFLNS YRHTHLDDPI AEVEPTDSEP YSCSKSCSRT CGQCKGSLER KSWTSSSSLS
      1450       1460       1470       1480       1490       1500
DTYEPNYGTV KQRVLESTPA ESSEGLDPKD ATDPVYKTVT SSTEKGLIVY CVTSPKKDDR
      1510       1520       1530       1540       1550       1560
YREPPPTPPG YLGISLADLK EGPHTHLKPP DYSVAVQRSK MMHNSLSRLP PASLSSNLVA
      1570       1580       1590       1600
CVPSKIVTQP QRHNLQPFHP KLGDVTDADS EADENEQVSA V         10         20         30         40         50         60
MNSPVDPGAR QALRKKPPER TPEDLNTIYS YLHGMEILSN LREHQLRLMS ARARYERYSG
        70         80         90        100        110        120
NQVLFCSETI ARCWYILLSG SVLVKGSMVL PPCSFGKQFG GKRGCDCLVL EPSEMIVVEN
       130        140        150        160        170        180
AKDNEDSILQ REIPARQSRR RFRKINYKGE RQTITDDVEV NSYLSLPADL TKMHLTENPH
       190        200        210        220        230        240
PQVTHVSSSQ SGCSIASDSG SSSLSDIYQA TESEVGDVDL TRLPEGPVDS EDDEEEDEEI
       250        260        270        280        290        300
DRTDPLQGRD LVRECLEKEP ADKTDDDIEQ LLEFMHQLPA FANMTMSVRR ELCSVMIFEV
       310        320        330        340        350        360
VEQAGAIILE DGQELDSWYV ILNGTVEISH PDGKVENLFM GNSFGITPTL DKQYMHGIVR
       370        380        390        400        410        420
TKVDDCQFVC IAQQDYWRIL NHVEKNTHKV EEEGEIVMVH EHRELDRSGT RKGHIVIKAT
       430        440        450        460        470        480
PERLIMHLIE EHSIVDPTYI EDFLLTYRTF LESPLDVGIK LLEWFKIDSL RDKVTRIVLL
       490        500        510        520        530        540
WVNNHFNDFE GDPAMTRFLE EFEKNLEDTK MNGHLRLLNI ACAAKAKWRQ VVLQKASRES
       550        560        570        580        590        600
PLQFSLNGGS EKGFGIFVEG VEPGSKAADS GLKRGDQIME VNGQNFENIT FMKAVEILRN
       610        620        630        640        650        660
NTHLALTVKT NIFVFKELLF RTEQEKSGVP HIPKIAEKKS NRHSIQHVPG DIEQTSQEKG
       670        680        690        700        710        720
SKKVKANTVS GGRNKIRKIL DKTRFSILPP KLFSDGGLSQ SQDDSIVGTR HCRHSLAIMP
       730        740        750        760        770        780
IPGTLSSSSP DLLQPTTSML DFSNPSDIPD QVIRVFKVDQ QSCYIIISKD TTAKEVVFHA
       790        800        810        820        830        840
VHEFGLTGAS DTYSLCEVSV TPEGVIKQRR LPDQFSKLAD RIQLNGRYYL KNNMETETLC
       850        860        870        880        890        900
SDEDAQELVK ESQLSMLQLS TIEVATQLSM RDFDLFRNIE PTEYIDDLFK LNSKTGNTHL
       910        920        930        940        950        960
KRFEDIVNQE TFWVASEILT EANQLKRMKI IKHFIKIALH CRECKNFNSM FAIISGLNLA
       970        980        990       1000       1010       1020
SVARLRGTWE KLPSKYEKHL QDLQDIFDPS RNMAKYRNIL SSQSMQPPII PLFPVVKKDM
      1030       1040       1050       1060       1070       1080
TFLHEGNDSK VDGLVNFEKL RMISKEIRQV VRMTSANMDP AMMFRQRSLS QGSTNSNMLD
      1090       1100       1110       1120       1130       1140
VQGGAHKKRA RRSSLLNAKK LYEDAQMARK VKQYLSSLDV ETDEEKFQMM SLQWEPAYGT
      1150       1160       1170       1180       1190       1200
LTKNLSEKRS AKSSEMSPVP MRSAGQTTKA HLHQPHRVSQ VLQVPAVNLH PIRKKGQTKD
      1210       1220       1230       1240       1250       1260
PALNTSLPQK VLGTTEEISG KKHTEDTISV ASSLHSSPPA SPQGSPHKGY TLIPSAKSDN
      1270       1280       1290       1300       1310       1320
LSDSSHSEIS SRSSIVSNCS VDSMSAALQD ERCSSQALAV PESTGALEKT EHASGIGDHS
      1330       1340       1350       1360       1370       1380
QHGPGWTLLK PSLIKCLAVS SSVSNEEISQ EHIIIEAADS GRGSWTSCSS SSHDNFQSLP
      1390       1400       1410       1420       1430       1440
NPKSWDFLNS YRHTHLDDPI AEVEPTDSEP YSCSKSCSRT CGQCKGSLER KSWTSSSSLS
      1450       1460       1470       1480       1490       1500
DTYEPNYGTV KQRVLESTPA ESSEGLDPKD ATDPVYKTVT SSTEKGLIVY CVTSPKKDDR
      1510       1520       1530       1540       1550       1560
YREPPPTPPG YLGISLADLK EGPHTHLKPP DYSVAVQRSK MMHNSLSRLP PASLSSNLVA
      1570       1580       1590       1600
CVPSKIVTQP QRHNLQPFHP KLGDVTDADS EADENEQVSA V

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

8 N-termini - 4 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q8TEU7-1-Acetylation	MNSPVD...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q8TEU7-1-Acetylation	MNSPVD...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q8TEU7-1-Acetylation	MNSPVD...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q8TEU7-1-Acetylation	MNSPVD...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt100347
Q8TEU7-1-Acetylation	MNSPVD...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt100348
Q8TEU7-1-Acetylation	MNSPVD...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt100349
Q8TEU7-1-Acetylation	MNSPVD...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt100350
Q8TEU7-1-Acetylation	MNSPVD...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt100351
Q8TEU7-1-unknown	MNSPVD...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt88149
Q8TEU7-1-unknown	MNSPVD...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt88150
Q8TEU7-1-unknown	MNSPVD...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt88151
Q8TEU7-1-unknown	MNSPVD...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt88152
Q8TEU7-1-unknown	MNSPVD...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt88153
Q8TEU7-162-unknown	SYLSLP...	162			unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q8TEU7-162-unknown	SYLSLP...	162		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt160183
Q8TEU7-162-unknown	SYLSLP...	162		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt160184
Q8TEU7-162-unknown	SYLSLP...	162		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt160185
Q8TEU7-162-unknown	SYLSLP...	162		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt160186
Q8TEU7-162-unknown	SYLSLP...	162		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt160187
Q8TEU7-1124-unknown	EEKFQM...	1124		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12928
Q8TEU7-1124-unknown	EEKFQM...	1124		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt157457
Q8TEU7-1124-unknown	EEKFQM...	1124		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt157474
Q8TEU7-1124-unknown	EEKFQM...	1124		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt157475
Q8TEU7-1124-unknown	EEKFQM...	1124		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt157484
Q8TEU7-1283-	SMSAAL...	1283			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q8TEU7-1283-	SMSAAL...	1283			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q8TEU7-1283-	SMSAAL...	1283			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q8TEU7-1283-	SMSAAL...	1283			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q8TEU7-1283-unknown	SMSAAL...	1283		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12933
Q8TEU7-1283-unknown	SMSAAL...	1283		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt157892
Q8TEU7-1283-unknown	SMSAAL...	1283		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt157893
Q8TEU7-1283-unknown	SMSAAL...	1283		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt157897
Q8TEU7-1457-unknown	STPAES...	1457		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172342
Q8TEU7-1457-unknown	STPAES...	1457		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172343
Q8TEU7-1457-unknown	STPAES...	1457		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172344
Q8TEU7-1457-	STPAES...	1457			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...QLNGRY	827	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt83771
...QLNGRY	827	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt93419
...QLNGRY	827	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt93420
...QLNGRY	827	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt93422
...QLNGRY	827	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt93421
...DVETDE	1123	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12928
...DVETDE	1123	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140955
...DVETDE	1123	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140972
...DVETDE	1123	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140973
...DVETDE	1123	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140982
...NCSVDS	1282	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12933
...NCSVDS	1282	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt141389
...NCSVDS	1282	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt141390
...NCSVDS	1282	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt141394
...QVSAV	1601	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...QVSAV	1601	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt83769

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	1123	ETDE.\|.EEKF	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
GRAB_HUMAN	1282	SVDS.\|.SMSA	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)