Q8WUI4: Histone deacetylase 7

General Information

Protein names	- Histone deacetylase 7 - HD7 - 3.5.1.98 - Histone deacetylase 7A - HD7a
Gene names	HDAC7
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q8WUI4

6 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Histone deacetylase 7 - Isoform 3 of Histone deacetylase 7 - Isoform 4 of Histone deacetylase 7 - Isoform 5 of Histone deacetylase 7 - Isoform 6 of Histone deacetylase 7 - Isoform 7 of Histone deacetylase 7 - Isoform 8 of Histone deacetylase 7 - Isoform 9 of Histone deacetylase 7 - Isoform 10 of Histone deacetylase 7

Sequence View

        10         20         30         40         50         60
MDLRVGQRPP VEPPPEPTLL ALQRPQRLHH HLFLAGLQQQ RSVEPMRLSM DTPMPELQVG
        70         80         90        100        110        120
PQEQELRQLL HKDKSKRSAV ASSVVKQKLA EVILKKQQAA LERTVHPNSP GIPYRTLEPL
       130        140        150        160        170        180
ETEGATRSML SSFLPPVPSL PSDPPEHFPL RKTVSEPNLK LRYKPKKSLE RRKNPLLRKE
       190        200        210        220        230        240
SAPPSLRRRP AETLGDSSPS SSSTPASGCS SPNDSEHGPN PILGSEALLG QRLRLQETSV
       250        260        270        280        290        300
APFALPTVSL LPAITLGLPA PARADSDRRT HPTLGPRGPI LGSPHTPLFL PHGLEPEAGG
       310        320        330        340        350        360
TLPSRLQPIL LLDPSGSHAP LLTVPGLGPL PFHFAQSLMT TERLSGSGLH WPLSRTRSEP
       370        380        390        400        410        420
LPPSATAPPP PGPMQPRLEQ LKTHVQVIKR SAKPSEKPRL RQIPSAEDLE TDGGGPGQVV
       430        440        450        460        470        480
DDGLEHRELG HGQPEARGPA PLQQHPQVLL WEQQRLAGRL PRGSTGDTVL LPLAQGGHRP
       490        500        510        520        530        540
LSRAQSSPAA PASLSAPEPA SQARVLSSSE TPARTLPFTT GLIYDSVMLK HQCSCGDNSR
       550        560        570        580        590        600
HPEHAGRIQS IWSRLQERGL RSQCECLRGR KASLEELQSV HSERHVLLYG TNPLSRLKLD
       610        620        630        640        650        660
NGKLAGLLAQ RMFVMLPCGG VGVDTDTIWN ELHSSNAARW AAGSVTDLAF KVASRELKNG
       670        680        690        700        710        720
FAVVRPPGHH ADHSTAMGFC FFNSVAIACR QLQQQSKASK ILIVDWDVHH GNGTQQTFYQ
       730        740        750        760        770        780
DPSVLYISLH RHDDGNFFPG SGAVDEVGAG SGEGFNVNVA WAGGLDPPMG DPEYLAAFRI
       790        800        810        820        830        840
VVMPIAREFS PDLVLVSAGF DAAEGHPAPL GGYHVSAKCF GYMTQQLMNL AGGAVVLALE
       850        860        870        880        890        900
GGHDLTAICD ASEACVAALL GNRVDPLSEE GWKQKPNLNA IRSLEAVIRV HSKYWGCMQR
       910        920        930        940        950
LASCPDSWVP RVPGADKEEV EAVTALASLS VGILAEDRPS EQLVEEEEPM NL         10         20         30         40         50         60
MDLRVGQRPP VEPPPEPTLL ALQRPQRLHH HLFLAGLQQQ RSVEPMRLSM DTPMPELQVG
        70         80         90        100        110        120
PQEQELRQLL HKDKSKRSAV ASSVVKQKLA EVILKKQQAA LERTVHPNSP GIPYRTLEPL
       130        140        150        160        170        180
ETEGATRSML SSFLPPVPSL PSDPPEHFPL RKTVSEPNLK LRYKPKKSLE RRKNPLLRKE
       190        200        210        220        230        240
SAPPSLRRRP AETLGDSSPS SSSTPASGCS SPNDSEHGPN PILGSEALLG QRLRLQETSV
       250        260        270        280        290        300
APFALPTVSL LPAITLGLPA PARADSDRRT HPTLGPRGPI LGSPHTPLFL PHGLEPEAGG
       310        320        330        340        350        360
TLPSRLQPIL LLDPSGSHAP LLTVPGLGPL PFHFAQSLMT TERLSGSGLH WPLSRTRSEP
       370        380        390        400        410        420
LPPSATAPPP PGPMQPRLEQ LKTHVQVIKR SAKPSEKPRL RQIPSAEDLE TDGGGPGQVV
       430        440        450        460        470        480
DDGLEHRELG HGQPEARGPA PLQQHPQVLL WEQQRLAGRL PRGSTGDTVL LPLAQGGHRP
       490        500        510        520        530        540
LSRAQSSPAA PASLSAPEPA SQARVLSSSE TPARTLPFTT GLIYDSVMLK HQCSCGDNSR
       550        560        570        580        590        600
HPEHAGRIQS IWSRLQERGL RSQCECLRGR KASLEELQSV HSERHVLLYG TNPLSRLKLD
       610        620        630        640        650        660
NGKLAGLLAQ RMFVMLPCGG VGVDTDTIWN ELHSSNAARW AAGSVTDLAF KVASRELKNG
       670        680        690        700        710        720
FAVVRPPGHH ADHSTAMGFC FFNSVAIACR QLQQQSKASK ILIVDWDVHH GNGTQQTFYQ
       730        740        750        760        770        780
DPSVLYISLH RHDDGNFFPG SGAVDEVGAG SGEGFNVNVA WAGGLDPPMG DPEYLAAFRI
       790        800        810        820        830        840
VVMPIAREFS PDLVLVSAGF DAAEGHPAPL GGYHVSAKCF GYMTQQLMNL AGGAVVLALE
       850        860        870        880        890        900
GGHDLTAICD ASEACVAALL GNRVDPLSEE GWKQKPNLNA IRSLEAVIRV HSKYWGCMQR
       910        920        930        940        950
LASCPDSWVP RVPGADKEEV EAVTALASLS VGILAEDRPS EQLVEEEEPM NL         10         20         30         40         50         60
MDLRVGQRPP VEPPPEPTLL ALQRPQRLHH HLFLAGLQQQ RSVEPMRLSM DTPMPELQVG
        70         80         90        100        110        120
PQEQELRQLL HKDKSKRSAV ASSVVKQKLA EVILKKQQAA LERTVHPNSP GIPYRTLEPL
       130        140        150        160        170        180
ETEGATRSML SSFLPPVPSL PSDPPEHFPL RKTVSEPNLK LRYKPKKSLE RRKNPLLRKE
       190        200        210        220        230        240
SAPPSLRRRP AETLGDSSPS SSSTPASGCS SPNDSEHGPN PILGSEALLG QRLRLQETSV
       250        260        270        280        290        300
APFALPTVSL LPAITLGLPA PARADSDRRT HPTLGPRGPI LGSPHTPLFL PHGLEPEAGG
       310        320        330        340        350        360
TLPSRLQPIL LLDPSGSHAP LLTVPGLGPL PFHFAQSLMT TERLSGSGLH WPLSRTRSEP
       370        380        390        400        410        420
LPPSATAPPP PGPMQPRLEQ LKTHVQVIKR SAKPSEKPRL RQIPSAEDLE TDGGGPGQVV
       430        440        450        460        470        480
DDGLEHRELG HGQPEARGPA PLQQHPQVLL WEQQRLAGRL PRGSTGDTVL LPLAQGGHRP
       490        500        510        520        530        540
LSRAQSSPAA PASLSAPEPA SQARVLSSSE TPARTLPFTT GLIYDSVMLK HQCSCGDNSR
       550        560        570        580        590        600
HPEHAGRIQS IWSRLQERGL RSQCECLRGR KASLEELQSV HSERHVLLYG TNPLSRLKLD
       610        620        630        640        650        660
NGKLAGLLAQ RMFVMLPCGG VGVDTDTIWN ELHSSNAARW AAGSVTDLAF KVASRELKNG
       670        680        690        700        710        720
FAVVRPPGHH ADHSTAMGFC FFNSVAIACR QLQQQSKASK ILIVDWDVHH GNGTQQTFYQ
       730        740        750        760        770        780
DPSVLYISLH RHDDGNFFPG SGAVDEVGAG SGEGFNVNVA WAGGLDPPMG DPEYLAAFRI
       790        800        810        820        830        840
VVMPIAREFS PDLVLVSAGF DAAEGHPAPL GGYHVSAKCF GYMTQQLMNL AGGAVVLALE
       850        860        870        880        890        900
GGHDLTAICD ASEACVAALL GNRVDPLSEE GWKQKPNLNA IRSLEAVIRV HSKYWGCMQR
       910        920        930        940        950
LASCPDSWVP RVPGADKEEV EAVTALASLS VGILAEDRPS EQLVEEEEPM NL         10         20         30         40         50         60
MDLRVGQRPP VEPPPEPTLL ALQRPQRLHH HLFLAGLQQQ RSVEPMRLSM DTPMPELQVG
        70         80         90        100        110        120
PQEQELRQLL HKDKSKRSAV ASSVVKQKLA EVILKKQQAA LERTVHPNSP GIPYRTLEPL
       130        140        150        160        170        180
ETEGATRSML SSFLPPVPSL PSDPPEHFPL RKTVSEPNLK LRYKPKKSLE RRKNPLLRKE
       190        200        210        220        230        240
SAPPSLRRRP AETLGDSSPS SSSTPASGCS SPNDSEHGPN PILGSEALLG QRLRLQETSV
       250        260        270        280        290        300
APFALPTVSL LPAITLGLPA PARADSDRRT HPTLGPRGPI LGSPHTPLFL PHGLEPEAGG
       310        320        330        340        350        360
TLPSRLQPIL LLDPSGSHAP LLTVPGLGPL PFHFAQSLMT TERLSGSGLH WPLSRTRSEP
       370        380        390        400        410        420
LPPSATAPPP PGPMQPRLEQ LKTHVQVIKR SAKPSEKPRL RQIPSAEDLE TDGGGPGQVV
       430        440        450        460        470        480
DDGLEHRELG HGQPEARGPA PLQQHPQVLL WEQQRLAGRL PRGSTGDTVL LPLAQGGHRP
       490        500        510        520        530        540
LSRAQSSPAA PASLSAPEPA SQARVLSSSE TPARTLPFTT GLIYDSVMLK HQCSCGDNSR
       550        560        570        580        590        600
HPEHAGRIQS IWSRLQERGL RSQCECLRGR KASLEELQSV HSERHVLLYG TNPLSRLKLD
       610        620        630        640        650        660
NGKLAGLLAQ RMFVMLPCGG VGVDTDTIWN ELHSSNAARW AAGSVTDLAF KVASRELKNG
       670        680        690        700        710        720
FAVVRPPGHH ADHSTAMGFC FFNSVAIACR QLQQQSKASK ILIVDWDVHH GNGTQQTFYQ
       730        740        750        760        770        780
DPSVLYISLH RHDDGNFFPG SGAVDEVGAG SGEGFNVNVA WAGGLDPPMG DPEYLAAFRI
       790        800        810        820        830        840
VVMPIAREFS PDLVLVSAGF DAAEGHPAPL GGYHVSAKCF GYMTQQLMNL AGGAVVLALE
       850        860        870        880        890        900
GGHDLTAICD ASEACVAALL GNRVDPLSEE GWKQKPNLNA IRSLEAVIRV HSKYWGCMQR
       910        920        930        940        950
LASCPDSWVP RVPGADKEEV EAVTALASLS VGILAEDRPS EQLVEEEEPM NL         10         20         30         40         50         60
MDLRVGQRPP VEPPPEPTLL ALQRPQRLHH HLFLAGLQQQ RSVEPMRLSM DTPMPELQVG
        70         80         90        100        110        120
PQEQELRQLL HKDKSKRSAV ASSVVKQKLA EVILKKQQAA LERTVHPNSP GIPYRTLEPL
       130        140        150        160        170        180
ETEGATRSML SSFLPPVPSL PSDPPEHFPL RKTVSEPNLK LRYKPKKSLE RRKNPLLRKE
       190        200        210        220        230        240
SAPPSLRRRP AETLGDSSPS SSSTPASGCS SPNDSEHGPN PILGSEALLG QRLRLQETSV
       250        260        270        280        290        300
APFALPTVSL LPAITLGLPA PARADSDRRT HPTLGPRGPI LGSPHTPLFL PHGLEPEAGG
       310        320        330        340        350        360
TLPSRLQPIL LLDPSGSHAP LLTVPGLGPL PFHFAQSLMT TERLSGSGLH WPLSRTRSEP
       370        380        390        400        410        420
LPPSATAPPP PGPMQPRLEQ LKTHVQVIKR SAKPSEKPRL RQIPSAEDLE TDGGGPGQVV
       430        440        450        460        470        480
DDGLEHRELG HGQPEARGPA PLQQHPQVLL WEQQRLAGRL PRGSTGDTVL LPLAQGGHRP
       490        500        510        520        530        540
LSRAQSSPAA PASLSAPEPA SQARVLSSSE TPARTLPFTT GLIYDSVMLK HQCSCGDNSR
       550        560        570        580        590        600
HPEHAGRIQS IWSRLQERGL RSQCECLRGR KASLEELQSV HSERHVLLYG TNPLSRLKLD
       610        620        630        640        650        660
NGKLAGLLAQ RMFVMLPCGG VGVDTDTIWN ELHSSNAARW AAGSVTDLAF KVASRELKNG
       670        680        690        700        710        720
FAVVRPPGHH ADHSTAMGFC FFNSVAIACR QLQQQSKASK ILIVDWDVHH GNGTQQTFYQ
       730        740        750        760        770        780
DPSVLYISLH RHDDGNFFPG SGAVDEVGAG SGEGFNVNVA WAGGLDPPMG DPEYLAAFRI
       790        800        810        820        830        840
VVMPIAREFS PDLVLVSAGF DAAEGHPAPL GGYHVSAKCF GYMTQQLMNL AGGAVVLALE
       850        860        870        880        890        900
GGHDLTAICD ASEACVAALL GNRVDPLSEE GWKQKPNLNA IRSLEAVIRV HSKYWGCMQR
       910        920        930        940        950
LASCPDSWVP RVPGADKEEV EAVTALASLS VGILAEDRPS EQLVEEEEPM NL         10         20         30         40         50         60
MDLRVGQRPP VEPPPEPTLL ALQRPQRLHH HLFLAGLQQQ RSVEPMRLSM DTPMPELQVG
        70         80         90        100        110        120
PQEQELRQLL HKDKSKRSAV ASSVVKQKLA EVILKKQQAA LERTVHPNSP GIPYRTLEPL
       130        140        150        160        170        180
ETEGATRSML SSFLPPVPSL PSDPPEHFPL RKTVSEPNLK LRYKPKKSLE RRKNPLLRKE
       190        200        210        220        230        240
SAPPSLRRRP AETLGDSSPS SSSTPASGCS SPNDSEHGPN PILGSEALLG QRLRLQETSV
       250        260        270        280        290        300
APFALPTVSL LPAITLGLPA PARADSDRRT HPTLGPRGPI LGSPHTPLFL PHGLEPEAGG
       310        320        330        340        350        360
TLPSRLQPIL LLDPSGSHAP LLTVPGLGPL PFHFAQSLMT TERLSGSGLH WPLSRTRSEP
       370        380        390        400        410        420
LPPSATAPPP PGPMQPRLEQ LKTHVQVIKR SAKPSEKPRL RQIPSAEDLE TDGGGPGQVV
       430        440        450        460        470        480
DDGLEHRELG HGQPEARGPA PLQQHPQVLL WEQQRLAGRL PRGSTGDTVL LPLAQGGHRP
       490        500        510        520        530        540
LSRAQSSPAA PASLSAPEPA SQARVLSSSE TPARTLPFTT GLIYDSVMLK HQCSCGDNSR
       550        560        570        580        590        600
HPEHAGRIQS IWSRLQERGL RSQCECLRGR KASLEELQSV HSERHVLLYG TNPLSRLKLD
       610        620        630        640        650        660
NGKLAGLLAQ RMFVMLPCGG VGVDTDTIWN ELHSSNAARW AAGSVTDLAF KVASRELKNG
       670        680        690        700        710        720
FAVVRPPGHH ADHSTAMGFC FFNSVAIACR QLQQQSKASK ILIVDWDVHH GNGTQQTFYQ
       730        740        750        760        770        780
DPSVLYISLH RHDDGNFFPG SGAVDEVGAG SGEGFNVNVA WAGGLDPPMG DPEYLAAFRI
       790        800        810        820        830        840
VVMPIAREFS PDLVLVSAGF DAAEGHPAPL GGYHVSAKCF GYMTQQLMNL AGGAVVLALE
       850        860        870        880        890        900
GGHDLTAICD ASEACVAALL GNRVDPLSEE GWKQKPNLNA IRSLEAVIRV HSKYWGCMQR
       910        920        930        940        950
LASCPDSWVP RVPGADKEEV EAVTALASLS VGILAEDRPS EQLVEEEEPM NL         10         20         30         40         50         60
MDLRVGQRPP VEPPPEPTLL ALQRPQRLHH HLFLAGLQQQ RSVEPMRLSM DTPMPELQVG
        70         80         90        100        110        120
PQEQELRQLL HKDKSKRSAV ASSVVKQKLA EVILKKQQAA LERTVHPNSP GIPYRTLEPL
       130        140        150        160        170        180
ETEGATRSML SSFLPPVPSL PSDPPEHFPL RKTVSEPNLK LRYKPKKSLE RRKNPLLRKE
       190        200        210        220        230        240
SAPPSLRRRP AETLGDSSPS SSSTPASGCS SPNDSEHGPN PILGSEALLG QRLRLQETSV
       250        260        270        280        290        300
APFALPTVSL LPAITLGLPA PARADSDRRT HPTLGPRGPI LGSPHTPLFL PHGLEPEAGG
       310        320        330        340        350        360
TLPSRLQPIL LLDPSGSHAP LLTVPGLGPL PFHFAQSLMT TERLSGSGLH WPLSRTRSEP
       370        380        390        400        410        420
LPPSATAPPP PGPMQPRLEQ LKTHVQVIKR SAKPSEKPRL RQIPSAEDLE TDGGGPGQVV
       430        440        450        460        470        480
DDGLEHRELG HGQPEARGPA PLQQHPQVLL WEQQRLAGRL PRGSTGDTVL LPLAQGGHRP
       490        500        510        520        530        540
LSRAQSSPAA PASLSAPEPA SQARVLSSSE TPARTLPFTT GLIYDSVMLK HQCSCGDNSR
       550        560        570        580        590        600
HPEHAGRIQS IWSRLQERGL RSQCECLRGR KASLEELQSV HSERHVLLYG TNPLSRLKLD
       610        620        630        640        650        660
NGKLAGLLAQ RMFVMLPCGG VGVDTDTIWN ELHSSNAARW AAGSVTDLAF KVASRELKNG
       670        680        690        700        710        720
FAVVRPPGHH ADHSTAMGFC FFNSVAIACR QLQQQSKASK ILIVDWDVHH GNGTQQTFYQ
       730        740        750        760        770        780
DPSVLYISLH RHDDGNFFPG SGAVDEVGAG SGEGFNVNVA WAGGLDPPMG DPEYLAAFRI
       790        800        810        820        830        840
VVMPIAREFS PDLVLVSAGF DAAEGHPAPL GGYHVSAKCF GYMTQQLMNL AGGAVVLALE
       850        860        870        880        890        900
GGHDLTAICD ASEACVAALL GNRVDPLSEE GWKQKPNLNA IRSLEAVIRV HSKYWGCMQR
       910        920        930        940        950
LASCPDSWVP RVPGADKEEV EAVTALASLS VGILAEDRPS EQLVEEEEPM NL         10         20         30         40         50         60
MDLRVGQRPP VEPPPEPTLL ALQRPQRLHH HLFLAGLQQQ RSVEPMRLSM DTPMPELQVG
        70         80         90        100        110        120
PQEQELRQLL HKDKSKRSAV ASSVVKQKLA EVILKKQQAA LERTVHPNSP GIPYRTLEPL
       130        140        150        160        170        180
ETEGATRSML SSFLPPVPSL PSDPPEHFPL RKTVSEPNLK LRYKPKKSLE RRKNPLLRKE
       190        200        210        220        230        240
SAPPSLRRRP AETLGDSSPS SSSTPASGCS SPNDSEHGPN PILGSEALLG QRLRLQETSV
       250        260        270        280        290        300
APFALPTVSL LPAITLGLPA PARADSDRRT HPTLGPRGPI LGSPHTPLFL PHGLEPEAGG
       310        320        330        340        350        360
TLPSRLQPIL LLDPSGSHAP LLTVPGLGPL PFHFAQSLMT TERLSGSGLH WPLSRTRSEP
       370        380        390        400        410        420
LPPSATAPPP PGPMQPRLEQ LKTHVQVIKR SAKPSEKPRL RQIPSAEDLE TDGGGPGQVV
       430        440        450        460        470        480
DDGLEHRELG HGQPEARGPA PLQQHPQVLL WEQQRLAGRL PRGSTGDTVL LPLAQGGHRP
       490        500        510        520        530        540
LSRAQSSPAA PASLSAPEPA SQARVLSSSE TPARTLPFTT GLIYDSVMLK HQCSCGDNSR
       550        560        570        580        590        600
HPEHAGRIQS IWSRLQERGL RSQCECLRGR KASLEELQSV HSERHVLLYG TNPLSRLKLD
       610        620        630        640        650        660
NGKLAGLLAQ RMFVMLPCGG VGVDTDTIWN ELHSSNAARW AAGSVTDLAF KVASRELKNG
       670        680        690        700        710        720
FAVVRPPGHH ADHSTAMGFC FFNSVAIACR QLQQQSKASK ILIVDWDVHH GNGTQQTFYQ
       730        740        750        760        770        780
DPSVLYISLH RHDDGNFFPG SGAVDEVGAG SGEGFNVNVA WAGGLDPPMG DPEYLAAFRI
       790        800        810        820        830        840
VVMPIAREFS PDLVLVSAGF DAAEGHPAPL GGYHVSAKCF GYMTQQLMNL AGGAVVLALE
       850        860        870        880        890        900
GGHDLTAICD ASEACVAALL GNRVDPLSEE GWKQKPNLNA IRSLEAVIRV HSKYWGCMQR
       910        920        930        940        950
LASCPDSWVP RVPGADKEEV EAVTALASLS VGILAEDRPS EQLVEEEEPM NL         10         20         30         40         50         60
MDLRVGQRPP VEPPPEPTLL ALQRPQRLHH HLFLAGLQQQ RSVEPMRLSM DTPMPELQVG
        70         80         90        100        110        120
PQEQELRQLL HKDKSKRSAV ASSVVKQKLA EVILKKQQAA LERTVHPNSP GIPYRTLEPL
       130        140        150        160        170        180
ETEGATRSML SSFLPPVPSL PSDPPEHFPL RKTVSEPNLK LRYKPKKSLE RRKNPLLRKE
       190        200        210        220        230        240
SAPPSLRRRP AETLGDSSPS SSSTPASGCS SPNDSEHGPN PILGSEALLG QRLRLQETSV
       250        260        270        280        290        300
APFALPTVSL LPAITLGLPA PARADSDRRT HPTLGPRGPI LGSPHTPLFL PHGLEPEAGG
       310        320        330        340        350        360
TLPSRLQPIL LLDPSGSHAP LLTVPGLGPL PFHFAQSLMT TERLSGSGLH WPLSRTRSEP
       370        380        390        400        410        420
LPPSATAPPP PGPMQPRLEQ LKTHVQVIKR SAKPSEKPRL RQIPSAEDLE TDGGGPGQVV
       430        440        450        460        470        480
DDGLEHRELG HGQPEARGPA PLQQHPQVLL WEQQRLAGRL PRGSTGDTVL LPLAQGGHRP
       490        500        510        520        530        540
LSRAQSSPAA PASLSAPEPA SQARVLSSSE TPARTLPFTT GLIYDSVMLK HQCSCGDNSR
       550        560        570        580        590        600
HPEHAGRIQS IWSRLQERGL RSQCECLRGR KASLEELQSV HSERHVLLYG TNPLSRLKLD
       610        620        630        640        650        660
NGKLAGLLAQ RMFVMLPCGG VGVDTDTIWN ELHSSNAARW AAGSVTDLAF KVASRELKNG
       670        680        690        700        710        720
FAVVRPPGHH ADHSTAMGFC FFNSVAIACR QLQQQSKASK ILIVDWDVHH GNGTQQTFYQ
       730        740        750        760        770        780
DPSVLYISLH RHDDGNFFPG SGAVDEVGAG SGEGFNVNVA WAGGLDPPMG DPEYLAAFRI
       790        800        810        820        830        840
VVMPIAREFS PDLVLVSAGF DAAEGHPAPL GGYHVSAKCF GYMTQQLMNL AGGAVVLALE
       850        860        870        880        890        900
GGHDLTAICD ASEACVAALL GNRVDPLSEE GWKQKPNLNA IRSLEAVIRV HSKYWGCMQR
       910        920        930        940        950
LASCPDSWVP RVPGADKEEV EAVTALASLS VGILAEDRPS EQLVEEEEPM NL

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

6 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q8WUI4-1-unknown	MDLRVG...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q8WUI4-1-unknown	MDLRVG...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt76806
Q8WUI4-1-unknown	MDLRVG...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt76807
Q8WUI4-1-unknown	MDLRVG...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt96120
Q8WUI4-1-unknown	MDLRVG...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt96119
Q8WUI4-1-unknown	MDLRVG...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt96121
Q8WUI4-1-unknown	MDLRVG...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt96118
Q8WUI4-413-unknown	GGGPGQ...	413	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3158
Q8WUI4-413-unknown	GGGPGQ...	413		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q8WUI4-413-unknown	GGGPGQ...	413	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151536
Q8WUI4-413-unknown	GGGPGQ...	413	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151699
Q8WUI4-413-unknown	GGGPGQ...	413	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152247
Q8WUI4-413-unknown	GGGPGQ...	413	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152550
Q8WUI4-413-unknown	GGGPGQ...	413	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152808
Q8WUI4-413-unknown	GGGPGQ...	413	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt153065
Q8WUI4-413-	GGGPGQ...	413		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q8WUI4-413-	GGGPGQ...	413		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q8WUI4-413-	GGGPGQ...	413		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q8WUI4-413-	GGGPGQ...	413		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q8WUI4-413-	GGGPGQ...	413		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q8WUI4-414-unknown	GGPGQV...	414	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175490
Q8WUI4-414-unknown	GGPGQV...	414	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175489
Q8WUI4-414-unknown	GGPGQV...	414	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175486
Q8WUI4-414-unknown	GGPGQV...	414	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175487
Q8WUI4-414-unknown	GGPGQV...	414	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175488
Q8WUI4-414-unknown	GGPGQV...	414	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175485
Q8WUI4-414-	GGPGQV...	414		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q8WUI4-528-unknown	MLKHQC...	528	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt76812
Q8WUI4-528-unknown	MLKHQC...	528	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt96488
Q8WUI4-528-unknown	MLKHQC...	528	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt96487
Q8WUI4-528-unknown	MLKHQC...	528	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt96486
Q8WUI4-528-unknown	MLKHQC...	528	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt96483
Q8WUI4-528-unknown	MLKHQC...	528	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt96484
Q8WUI4-528-unknown	MLKHQC...	528	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt96485
Q8WUI4-528-unknown	MLKHQC...	528	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt96482

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...DLETDG	412	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3158
...DLETDG	412	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134941
...DLETDG	412	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135102
...DLETDG	412	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135657
...DLETDG	412	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135964
...DLETDG	412	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136233
...DLETDG	412	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136490
...EPMNL	952	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...EPMNL	952	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72430
...EPMNL	952	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72423
...EPMNL	952	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72424
...EPMNL	952	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72425
...EPMNL	952	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72428
...EPMNL	952	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72427
...EPMNL	952	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72426

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP8_HUMAN	412	ETDG.\|.GGGP	inferred from experiment	unknown	MEROPS	Salvesen GS	Scott FL et al.:Caspase-8 cleaves histone deace... (C14.009)	18458084,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)