Q8WVC0: RNA polymerase-associated protein LEO1

General Information

Protein names	- RNA polymerase-associated protein LEO1 - Replicative senescence down-regulated leo1-like protein
Gene names	LEO1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q8WVC0

6 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MADMEDLFGS DADSEAERKD SDSGSDSDSD QENAASGSNA SGSESDQDER GDSGQPSNKE
        70         80         90        100        110        120
LFGDDSEDEG ASHHSGSDNH SERSDNRSEA SERSDHEDND PSDVDQHSGS EAPNDDEDEG
       130        140        150        160        170        180
HRSDGGSHHS EAEGSEKAHS DDEKWGREDK SDQSDDEKIQ NSDDEERAQG SDEDKLQNSD
       190        200        210        220        230        240
DDEKMQNTDD EERPQLSDDE RQQLSEEEKA NSDDERPVAS DNDDEKQNSD DEEQPQLSDE
       250        260        270        280        290        300
EKMQNSDDER PQASDEEHRH SDDEEEQDHK SESARGSDSE DEVLRMKRKN AIASDSEADS
       310        320        330        340        350        360
DTEVPKDNSG TMDLFGGADD ISSGSDGEDK PPTPGQPVDE NGLPQDQQEE EPIPETRIEV
       370        380        390        400        410        420
EIPKVNTDLG NDLYFVKLPN FLSVEPRPFD PQYYEDEFED EEMLDEEGRT RLKLKVENTI
       430        440        450        460        470        480
RWRIRRDEEG NEIKESNARI VKWSDGSMSL HLGNEVFDVY KAPLQGDHNH LFIRQGTGLQ
       490        500        510        520        530        540
GQAVFKTKLT FRPHSTDSAT HRKMTLSLAD RCSKTQKIRI LPMAGRDPEC QRTEMIKKEE
       550        560        570        580        590        600
ERLRASIRRE SQQRRMREKQ HQRGLSASYL EPDRYDEEEE GEESISLAAI KNRYKGGIRE
       610        620        630        640        650        660
ERARIYSSDS DEGSEEDKAQ RLLKAKKLTS DEEGEPSGKR KAEDDDKANK KHKKYVISDE

EEEDDD

Isoforms

- Isoform 2 of RNA polymerase-associated protein LEO1

Sequence View

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Protein Neighborhood

Domains & Features

6 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q8WVC0-1-unknown	MADMED...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt79510
Q8WVC0-2-unknown	MADMED...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q8WVC0-2-Acetylation	ADMEDL...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q8WVC0-2-Acetylation	ADMEDL...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt111453
Q8WVC0-342-	GLPQDQ...	342			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q8WVC0-342-	GLPQDQ...	342			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q8WVC0-342-unknown	GLPQDQ...	342		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt171355
Q8WVC0-574-unknown	RYDEEE...	574		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12946
Q8WVC0-574-unknown	RYDEEE...	574		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt153581

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...YLEPDR	573	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12946
...YLEPDR	573	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt137004
...EEDDD	666	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...EEDDD	666	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt75128

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	573	EPDR.\|.RYDE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)