Q8WYQ5: Microprocessor complex subunit DGCR8
Protein names | - Microprocessor complex subunit DGCR8 - DiGeorge syndrome critical region 8 |
---|---|
Gene names | DGCR8 |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | Q8WYQ5 |
8
N-termini
4
C-termini
3
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
METDESPSPL PCGPAGEAVM ESRARPFQAL PREQSPPPPL QTSSGAEVMD VGSGGDGQSE
70 80 90 100 110 120
LPAEDPFNFY GASLLSKGSF SKGRLLIDPN CSGHSPRTAR HAPAVRKFSP DLKLLKDVKI
130 140 150 160 170 180
SVSFTESCRS KDRKVLYTGA ERDVRAECGL LLSPVSGDVH ACPFGGSVGD GVGIGGESAD
190 200 210 220 230 240
KKDEENELDQ EKRVEYAVLD ELEDFTDNLE LDEEGAGGFT AKAIVQRDRV DEEALNFPYE
250 260 270 280 290 300
DDFDNDVDAL LEEGLCAPKK RRTEEKYGGD SDHPSDGETS VQPMMTKIKT VLKSRGRPPT
310 320 330 340 350 360
EPLPDGWIMT FHNSGVPVYL HRESRVVTWS RPYFLGTGSI RKHDPPLSSI PCLHYKKMKD
370 380 390 400 410 420
NEEREQSSDL TPSGDVSPVK PLSRSAELEF PLDEPDSMGA DPGPPDEKDP LGAEAAPGAL
430 440 450 460 470 480
GQVKAKVEVC KDESVDLEEF RSYLEKRFDF EQVTVKKFRT WAERRQFNRE MKRKQAESER
490 500 510 520 530 540
PILPANQKLI TLSVQDAPTK KEFVINPNGK SEVCILHEYM QRVLKVRPVY NFFECENPSE
550 560 570 580 590 600
PFGASVTIDG VTYGSGTASS KKLAKNKAAR ATLEILIPDF VKQTSEEKPK DSEELEYFNH
610 620 630 640 650 660
ISIEDSRVYE LTSKAGLLSP YQILHECLKR NHGMGDTSIK FEVVPGKNQK SEYVMACGKH
670 680 690 700 710 720
TVRGWCKNKR VGKQLASQKI LQLLHPHVKN WGSLLRMYGR ESSKMVKQET SDKSVIELQQ
730 740 750 760 770
YAKKNKPNLH ILSKLQEEMK RLAEEREETR KKPKMSIVAS AQPGGEPLCT VDV
Isoforms
- Isoform 2 of Microprocessor complex subunit DGCR8 - Isoform 3 of Microprocessor complex subunit DGCR8Sequence View
10 20 30 40 50 60
METDESPSPL PCGPAGEAVM ESRARPFQAL PREQSPPPPL QTSSGAEVMD VGSGGDGQSE
70 80 90 100 110 120
LPAEDPFNFY GASLLSKGSF SKGRLLIDPN CSGHSPRTAR HAPAVRKFSP DLKLLKDVKI
130 140 150 160 170 180
SVSFTESCRS KDRKVLYTGA ERDVRAECGL LLSPVSGDVH ACPFGGSVGD GVGIGGESAD
190 200 210 220 230 240
KKDEENELDQ EKRVEYAVLD ELEDFTDNLE LDEEGAGGFT AKAIVQRDRV DEEALNFPYE
250 260 270 280 290 300
DDFDNDVDAL LEEGLCAPKK RRTEEKYGGD SDHPSDGETS VQPMMTKIKT VLKSRGRPPT
310 320 330 340 350 360
EPLPDGWIMT FHNSGVPVYL HRESRVVTWS RPYFLGTGSI RKHDPPLSSI PCLHYKKMKD
370 380 390 400 410 420
NEEREQSSDL TPSGDVSPVK PLSRSAELEF PLDEPDSMGA DPGPPDEKDP LGAEAAPGAL
430 440 450 460 470 480
GQVKAKVEVC KDESVDLEEF RSYLEKRFDF EQVTVKKFRT WAERRQFNRE MKRKQAESER
490 500 510 520 530 540
PILPANQKLI TLSVQDAPTK KEFVINPNGK SEVCILHEYM QRVLKVRPVY NFFECENPSE
550 560 570 580 590 600
PFGASVTIDG VTYGSGTASS KKLAKNKAAR ATLEILIPDF VKQTSEEKPK DSEELEYFNH
610 620 630 640 650 660
ISIEDSRVYE LTSKAGLLSP YQILHECLKR NHGMGDTSIK FEVVPGKNQK SEYVMACGKH
670 680 690 700 710 720
TVRGWCKNKR VGKQLASQKI LQLLHPHVKN WGSLLRMYGR ESSKMVKQET SDKSVIELQQ
730 740 750 760 770
YAKKNKPNLH ILSKLQEEMK RLAEEREETR KKPKMSIVAS AQPGGEPLCT VDV
10 20 30 40 50 60
METDESPSPL PCGPAGEAVM ESRARPFQAL PREQSPPPPL QTSSGAEVMD VGSGGDGQSE
70 80 90 100 110 120
LPAEDPFNFY GASLLSKGSF SKGRLLIDPN CSGHSPRTAR HAPAVRKFSP DLKLLKDVKI
130 140 150 160 170 180
SVSFTESCRS KDRKVLYTGA ERDVRAECGL LLSPVSGDVH ACPFGGSVGD GVGIGGESAD
190 200 210 220 230 240
KKDEENELDQ EKRVEYAVLD ELEDFTDNLE LDEEGAGGFT AKAIVQRDRV DEEALNFPYE
250 260 270 280 290 300
DDFDNDVDAL LEEGLCAPKK RRTEEKYGGD SDHPSDGETS VQPMMTKIKT VLKSRGRPPT
310 320 330 340 350 360
EPLPDGWIMT FHNSGVPVYL HRESRVVTWS RPYFLGTGSI RKHDPPLSSI PCLHYKKMKD
370 380 390 400 410 420
NEEREQSSDL TPSGDVSPVK PLSRSAELEF PLDEPDSMGA DPGPPDEKDP LGAEAAPGAL
430 440 450 460 470 480
GQVKAKVEVC KDESVDLEEF RSYLEKRFDF EQVTVKKFRT WAERRQFNRE MKRKQAESER
490 500 510 520 530 540
PILPANQKLI TLSVQDAPTK KEFVINPNGK SEVCILHEYM QRVLKVRPVY NFFECENPSE
550 560 570 580 590 600
PFGASVTIDG VTYGSGTASS KKLAKNKAAR ATLEILIPDF VKQTSEEKPK DSEELEYFNH
610 620 630 640 650 660
ISIEDSRVYE LTSKAGLLSP YQILHECLKR NHGMGDTSIK FEVVPGKNQK SEYVMACGKH
670 680 690 700 710 720
TVRGWCKNKR VGKQLASQKI LQLLHPHVKN WGSLLRMYGR ESSKMVKQET SDKSVIELQQ
730 740 750 760 770
YAKKNKPNLH ILSKLQEEMK RLAEEREETR KKPKMSIVAS AQPGGEPLCT VDV
Protein Neighborhood
Domains & Features
8 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
Q8WYQ5-1-acetylation | METDES... | 1 | acetylation- | COFRADIC | Gevaert K. | Van Damme P et al.: Complementary positional proteomics for screening substrates... | 20526345 | ||
Q8WYQ5-1-acetylation | METDES... | 1 | acetylation- | COFRADIC | Gevaert K. | Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates... | 20526345 | ||
Q8WYQ5-1-acetylation | METDES... | 1 | acetylation- | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt162868 | ||
Q8WYQ5-1-acetylation | METDES... | 1 | acetylation- | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt162869 | ||
Q8WYQ5-1-unknown | METDES... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
Q8WYQ5-1-unknown | METDES... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt72665 | |||
Q8WYQ5-1-unknown | METDES... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt72666 | |||
Q8WYQ5-249-unknown | ALLEEG... | 249 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC12984 | |||
Q8WYQ5-249-unknown | ALLEEG... | 249 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt148386 | |||
Q8WYQ5-249-unknown | ALLEEG... | 249 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt148387 | |||
Q8WYQ5-397- | SMGADP... | 397 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
Q8WYQ5-397- | SMGADP... | 397 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
Q8WYQ5-397- | SMGADP... | 397 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
Q8WYQ5-397- | SMGADP... | 397 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 | |||
Q8WYQ5-397- | SMGADP... | 397 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
Q8WYQ5-397-unknown | SMGADP... | 397 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC12987 | |||
Q8WYQ5-397-unknown | SMGADP... | 397 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt151958 | |||
Q8WYQ5-399- | GADPGP... | 399 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
Q8WYQ5-399-unknown | GADPGP... | 399 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt172290 | |||
Q8WYQ5-433-unknown | ESVDLE... | 433 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC12989 | |||
Q8WYQ5-433-unknown | ESVDLE... | 433 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt152531 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...DNDVDA | 248 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC12984 | |||
...DNDVDA | 248 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt131758 | |||
...DNDVDA | 248 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt131759 | |||
...LDEPDS | 396 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC12987 | |||
...LDEPDS | 396 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt135366 | |||
...EVCKDE | 432 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC12989 | |||
...EVCKDE | 432 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt135942 | |||
...CTVDV | 773 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...CTVDV | 773 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt68284 |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
GRAB_HUMAN | 248 | DVDA.|.ALLE | inferred from experiment | unknown | MEROPS | Gevaert K | Van Damme P et al.:Complementary positional proteo... (M14.017) | 20526345, |
GRAB_HUMAN | 396 | EPDS.|.SMGA | inferred from experiment | unknown | MEROPS | Gevaert K | Van Damme P et al.:Complementary positional proteo... (M14.017) | 20526345, |
GRAB_HUMAN | 432 | CKDE.|.ESVD | inferred from experiment | unknown | MEROPS | Gevaert K | Van Damme P et al.:Complementary positional proteo... (M14.017) | 20526345, |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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