Q96BN8: Ubiquitin thioesterase otulin {ECO:0000305}

General Information

Protein names	- Ubiquitin thioesterase otulin {ECO:0000305} - 3.4.19.12 {ECO:0000269\|PubMed:23746843, ECO:0000269\|PubMed:23827681, ECO:0000269\|PubMed:27523608, ECO:0000269\|PubMed:28919039} - Deubiquitinating enzyme otulin {ECO:0000303\|PubMed:23806334} - OTU domain-containing deubiquitinase with linear linkage specificity {ECO:0000303\|PubMed:23806334} - Ubiquitin thioesterase Gumby {ECO:0000250\|UniProtKB:Q3UCV8}
Gene names	OTULIN
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q96BN8

5 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSRGTMPQPE AWPGASCAET PAREAAATAR DGGKAAASGQ PRPEMQCPAE HEEDMYRAAD
        70         80         90        100        110        120
EIEKEKELLI HERGASEPRL SVAPEMDIMD YCKKEWRGNT QKATCMKMGY EEVSQKFTSI
       130        140        150        160        170        180
RRVRGDNYCA LRATLFQAMS QAVGLPPWLQ DPELMLLPEK LISKYNWIKQ WKLGLKFDGK
       190        200        210        220        230        240
NEDLVDKIKE SLTLLRKKWA GLAEMRTAEA RQIACDELFT NEAEEYSLYE AVKFLMLNRA
       250        260        270        280        290        300
IELYNDKEKG KEVPFFSVLL FARDTSNDPG QLLRNHLNQV GHTGGLEQVE MFLLAYAVRH
       310        320        330        340        350
TIQVYRLSKY NTEEFITVYP TDPPKDWPVV TLIAEDDRHY NIPVRVCEET SL

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

5 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q96BN8-1-unknown	MSRGTM...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q96BN8-35-	AAASGQ...	35			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q96BN8-45-acetylation	MQCPAE...	45	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
Q96BN8-58-	AADEIE...	58			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q96BN8-70-unknown	IHERGA...	70		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14822

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...EKELLI	69	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14822
	...EETSL	352	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	69	ELLI.\|.IHER	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)