Q96EB6: NAD-dependent protein deacetylase sirtuin-1

General Information

Protein names	- NAD-dependent protein deacetylase sirtuin-1 - hSIRT1 - 3.5.1.- - Regulatory protein SIR2 homolog 1 - SIR2-like protein 1 - hSIR2 - SirtT1 75 kDa fragment - 75SirT1
Gene names	SIRT1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q96EB6

6 N-termini

4 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MADEAALALQ PGGSPSAAGA DREAASSPAG EPLRKRPRRD GPGLERSPGE PGGAAPEREV
        70         80         90        100        110        120
PAAARGCPGA AAAALWREAE AEAAAAGGEQ EAQATAAAGE GDNGPGLQGP SREPPLADNL
       130        140        150        160        170        180
YDEDDDDEGE EEEEAAAAAI GYRDNLLFGD EIITNGFHSC ESDEEDRASH ASSSDWTPRP
       190        200        210        220        230        240
RIGPYTFVQQ HLMIGTDPRT ILKDLLPETI PPPELDDMTL WQIVINILSE PPKRKKRKDI
       250        260        270        280        290        300
NTIEDAVKLL QECKKIIVLT GAGVSVSCGI PDFRSRDGIY ARLAVDFPDL PDPQAMFDIE
       310        320        330        340        350        360
YFRKDPRPFF KFAKEIYPGQ FQPSLCHKFI ALSDKEGKLL RNYTQNIDTL EQVAGIQRII
       370        380        390        400        410        420
QCHGSFATAS CLICKYKVDC EAVRGDIFNQ VVPRCPRCPA DEPLAIMKPE IVFFGENLPE
       430        440        450        460        470        480
QFHRAMKYDK DEVDLLIVIG SSLKVRPVAL IPSSIPHEVP QILINREPLP HLHFDVELLG
       490        500        510        520        530        540
DCDVIINELC HRLGGEYAKL CCNPVKLSEI TEKPPRTQKE LAYLSELPPT PLHVSEDSSS
       550        560        570        580        590        600
PERTSPPDSS VIVTLLDQAA KSNDDLDVSE SKGCMEEKPQ EVQTSRNVES IAEQMENPDL
       610        620        630        640        650        660
KNVGSSTGEK NERTSVAGTV RKCWPNRVAK EQISRRLDGN QYLFLPPNRY IFHGAEVYSD
       670        680        690        700        710        720
SEDDVLSSSS CGSNSDSGTC QSPSLEEPME DESEIEEFYN GLEDEPDVPE RAGGAGFGTD
       730        740
GDDQEAINEA ISVKQEVTDM NYPSNKS

Isoforms

- Isoform 2 of NAD-dependent protein deacetylase sirtuin-1

Sequence View

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Protein Neighborhood

Domains & Features

6 N-termini - 4 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q96EB6-1-unknown	MADEAA...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt89786
Q96EB6-2-unknown	MADEAA...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q96EB6-2-Acetylation	ADEAAL...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q96EB6-2-Acetylation	ADEAAL...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q96EB6-2-Acetylation	ADEAAL...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
Q96EB6-2-Acetylation	ADEAAL...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q96EB6-2-Acetylation	ADEAAL...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110929
Q96EB6-156-unknown	GFHSCE...	156		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13057
Q96EB6-156-unknown	GFHSCE...	156		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt144967
Q96EB6-533-unknown	HVSEDS...	533		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14825
Q96EB6-590-	SIAEQM...	590			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q96EB6-590-	SIAEQM...	590			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...EIITNG	155	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13057
...EIITNG	155	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128244
...PPTPLH	532	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14825
...PTPLHV	533	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...PSNKS	747	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...PSNKS	747	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt85404

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	155	ITNG.\|.GFHS	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAM_HUMAN	532	TPLH.\|.HVSE	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)