Q96EY5: Multivesicular body subunit 12A

General Information

Protein names	- Multivesicular body subunit 12A - CIN85/CD2AP family-binding protein - ESCRT-I complex subunit MVB12A - Protein FAM125A
Gene names	MVB12A
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q96EY5

4 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Multivesicular body subunit 12A - Isoform 3 of Multivesicular body subunit 12A

Sequence View

        10         20         30         40         50         60
MDPVPGTDSA PLAGLAWSSA SAPPPRGFSA ISCTVEGAPA SFGKSFAQKS GYFLCLSSLG
        70         80         90        100        110        120
SLENPQENVV ADIQIVVDKS PLPLGFSPVC DPMDSKASVS KKKRMCVKLL PLGATDTAVF
       130        140        150        160        170        180
DVRLSGKTKT VPGYLRIGDM GGFAIWCKKA KAPRPVPKPR GLSRDMQGLS LDAASQPSKG
       190        200        210        220        230        240
GLLERTASRL GSRASTLRRN DSIYEASSLY GISAMDGVPF TLHPRFEGKS CSPLAFSAFG
       250        260        270
DLTIKSLADI EEEYNYGFVV EKTAAARLPP SVS         10         20         30         40         50         60
MDPVPGTDSA PLAGLAWSSA SAPPPRGFSA ISCTVEGAPA SFGKSFAQKS GYFLCLSSLG
        70         80         90        100        110        120
SLENPQENVV ADIQIVVDKS PLPLGFSPVC DPMDSKASVS KKKRMCVKLL PLGATDTAVF
       130        140        150        160        170        180
DVRLSGKTKT VPGYLRIGDM GGFAIWCKKA KAPRPVPKPR GLSRDMQGLS LDAASQPSKG
       190        200        210        220        230        240
GLLERTASRL GSRASTLRRN DSIYEASSLY GISAMDGVPF TLHPRFEGKS CSPLAFSAFG
       250        260        270
DLTIKSLADI EEEYNYGFVV EKTAAARLPP SVS

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q96EY5-1-unknown	MDPVPG...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q96EY5-1-unknown	MDPVPG...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt80501
Q96EY5-1-unknown	MDPVPG...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt80502
Q96EY5-170-unknown	SLDAAS...	170	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14826
Q96EY5-170-unknown	SLDAAS...	170	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145545
Q96EY5-173-	AASQPS...	173		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q96EY5-173-	AASQPS...	173		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q96EY5-173-	AASQPS...	173		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q96EY5-173-	AASQPS...	173		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q96EY5-173-	AASQPS...	173		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q96EY5-173-unknown	AASQPS...	173		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q96EY5-173-unknown	AASQPS...	173	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161519

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...DMQGLS	169	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14826
...DMQGLS	169	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128843
...PPSVS	273	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...PPSVS	273	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt76119

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	169	QGLS.\|.SLDA	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)