Q96GQ7: Probable ATP-dependent RNA helicase DDX27

General Information

Protein names	- Probable ATP-dependent RNA helicase DDX27 - 3.6.4.13 - DEAD box protein 27
Gene names	DDX27
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q96GQ7

6 N-termini

4 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MVLAQRRRGG CEKLRAGPQA VLASGSGFCD NMLADLGLIG TIGEDDEVPV EPESDSGDEE
        70         80         90        100        110        120
EEGPIVLGRR QKALGKNRSA DFNPDFVFTE KEGTYDGSWA LADVMSQLKK KRAATTLDEK
       130        140        150        160        170        180
IEKVRKKRKT EDKEAKSGKL EKEKEAKEGS EPKEQEDLQE NDEEGSEDEA SETDYSSADE
       190        200        210        220        230        240
NILTKADTLK VKDRKKKKKK GQEAGGFFED ASQYDENLSF QDMNLSRPLL KAITAMGFKQ
       250        260        270        280        290        300
PTPIQKACIP VGLLGKDICA CAATGTGKTA AFALPVLERL IYKPRQAPVT RVLVLVPTRE
       310        320        330        340        350        360
LGIQVHSVTR QLAQFCNITT CLAVGGLDVK SQEAALRAAP DILIATPGRL IDHLHNCPSF
       370        380        390        400        410        420
HLSSIEVLIL DEADRMLDEY FEEQMKEIIR MCSHHRQTML FSATMTDEVK DLASVSLKNP
       430        440        450        460        470        480
VRIFVNSNTD VAPFLRQEFI RIRPNREGDR EAIVAALLTR TFTDHVMLFT QTKKQAHRMH
       490        500        510        520        530        540
ILLGLMGLQV GELHGNLSQT QRLEALRRFK DEQIDILVAT DVAARGLDIE GVKTVINFTM
       550        560        570        580        590        600
PNTIKHYVHR VGRTARAGRA GRSVSLVGED ERKMLKEIVK AAKAPVKARI LPQDVILKFR
       610        620        630        640        650        660
DKIEKMEKDV YAVLQLEAEE KEMQQSEAQI NTAKRLLEKG KEAVVQEPER SWFQTKEERK
       670        680        690        700        710        720
KEKIAKALQE FDLALRGKKK RKKFMKDAKK KGEMTAEERS QFEILKAQMF AERLAKRNRR
       730        740        750        760        770        780
AKRARAMPEE EPVRGPAKKQ KQGKKSVFDE ELTNTSKKAL KQYRAGPSFE ERKQLGLPHQ
       790
RRGGNFKSKS RYKRRK

Isoforms

Sequence View

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Evidence Names:

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Protein Neighborhood

Domains & Features

6 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q96GQ7-1-unknown	MVLAQR...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q96GQ7-32-unknown	MLADLG...	32	inferred from electronic annotation	unknown	TISdb		inferred from TISdb
Q96GQ7-104-unknown	VMSQLK...	104	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13066
Q96GQ7-188-unknown	TLKVKD...	188	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13067
Q96GQ7-232-	AITAMG...	232		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q96GQ7-670-unknown	EFDLAL...	670	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14832

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...WALADV	103	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13066
...LTKADT	187	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13067
...AKALQE	669	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14832
...YKRRK	796	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	103	LADV.\|.VMSQ	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAB_HUMAN	187	KADT.\|.TLKV	inferred from experiment	unknown	MEROPS		Merops GRAB_HUMAN -> DDX27_HUMAN @187
GRAB_HUMAN	187	KADT.\|.TLKV	inferred from experiment	unknown	MEROPS	Gevaert K	Plasman K et al.:Probing the efficiency of prote... (S01.010)	21048194,
GRAM_HUMAN	669	ALQE.\|.EFDL	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)