Q96K76: Ubiquitin carboxyl-terminal hydrolase 47

General Information

Protein names	- Ubiquitin carboxyl-terminal hydrolase 47 - 3.4.19.12 - Deubiquitinating enzyme 47 - Ubiquitin thioesterase 47 - Ubiquitin-specific-processing protease 47
Gene names	USP47
Organism	Homo sapiens
Protease Family
Protease ID	C19.055
Chromosome location
UniProt ID	Q96K76

9 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Ubiquitin carboxyl-terminal hydrolase 47 - Isoform 3 of Ubiquitin carboxyl-terminal hydrolase 47 - Isoform 4 of Ubiquitin carboxyl-terminal hydrolase 47

Sequence View

        10         20         30         40         50         60
MVPGEENQLV PKEDVFWRCR QNIFDEMKKK FLQIENAAEE PRVLCIIQDT TNSKTVNERI
        70         80         90        100        110        120
TLNLPASTPV RKLFEDVANK VGYINGTFDL VWGNGINTAD MAPLDHTSDK SLLDANFEPG
       130        140        150        160        170        180
KKNFLHLTDK DGEQPQILLE DSSAGEDSVH DRFIGPLPRE GSGGSTSDYV SQSYSYSSIL
       190        200        210        220        230        240
NKSETGYVGL VNQAMTCYLN SLLQTLFMTP EFRNALYKWE FEESEEDPVT SIPYQLQRLF
       250        260        270        280        290        300
VLLQTSKKRA IETTDVTRSF GWDSSEAWQQ HDVQELCRVM FDALEQKWKQ TEQADLINEL
       310        320        330        340        350        360
YQGKLKDYVR CLECGYEGWR IDTYLDIPLV IRPYGSSQAF ASVEEALHAF IQPEILDGPN
       370        380        390        400        410        420
QYFCERCKKK CDARKGLRFL HFPYLLTLQL KRFDFDYTTM HRIKLNDRMT FPEELDMSTF
       430        440        450        460        470        480
IDVEDEKSPQ TESCTDSGAE NEGSCHSDQM SNDFSNDDGV DEGICLETNS GTEKISKSGL
       490        500        510        520        530        540
EKNSLIYELF SVMVHSGSAA GGHYYACIKS FSDEQWYSFN DQHVSRITQE DIKKTHGGSS
       550        560        570        580        590        600
GSRGYYSSAF ASSTNAYMLI YRLKDPARNA KFLEVDEYPE HIKNLVQKER ELEEQEKRQR
       610        620        630        640        650        660
EIERNTCKIK LFCLHPTKQV MMENKLEVHK DKTLKEAVEM AYKMMDLEEV IPLDCCRLVK
       670        680        690        700        710        720
YDEFHDYLER SYEGEEDTPM GLLLGGVKST YMFDLLLETR KPDQVFQSYK PGEVMVKVHV
       730        740        750        760        770        780
VDLKAESVAA PITVRAYLNQ TVTEFKQLIS KAIHLPAETM RIVLERCYND LRLLSVSSKT
       790        800        810        820        830        840
LKAEGFFRSN KVFVESSETL DYQMAFADSH LWKLLDRHAN TIRLFVLLPE QSPVSYSKRT
       850        860        870        880        890        900
AYQKAGGDSG NVDDDCERVK GPVGSLKSVE AILEESTEKL KSLSLQQQQD GDNGDSSKST
       910        920        930        940        950        960
ETSDFENIES PLNERDSSAS VDNRELEQHI QTSDPENFQS EERSDSDVNN DRSTSSVDSD
       970        980        990       1000       1010       1020
ILSSSHSSDT LCNADNAQIP LANGLDSHSI TSSRRTKANE GKKETWDTAE EDSGTDSEYD
      1030       1040       1050       1060       1070       1080
ESGKSRGEMQ YMYFKAEPYA ADEGSGEGHK WLMVHVDKRI TLAAFKQHLE PFVGVLSSHF
      1090       1100       1110       1120       1130       1140
KVFRVYASNQ EFESVRLNET LSSFSDDNKI TIRLGRALKK GEYRVKVYQL LVNEQEPCKF
      1150       1160       1170       1180       1190       1200
LLDAVFAKGM TVRQSKEELI PQLREQCGLE LSIDRFRLRK KTWKNPGTVF LDYHIYEEDI
      1210       1220       1230       1240       1250       1260
NISSNWEVFL EVLDGVEKMK SMSQLAVLSR RWKPSEMKLD PFQEVVLESS SVDELREKLS
      1270       1280       1290       1300       1310       1320
EISGIPLDDI EFAKGRGTFP CDISVLDIHQ DLDWNPKVST LNVWPLYICD DGAVIFYRDK
      1330       1340       1350       1360       1370
TEELMELTDE QRNELMKKES SRLQKTGHRV TYSPRKEKAL KIYLDGAPNK DLTQD         10         20         30         40         50         60
MVPGEENQLV PKEDVFWRCR QNIFDEMKKK FLQIENAAEE PRVLCIIQDT TNSKTVNERI
        70         80         90        100        110        120
TLNLPASTPV RKLFEDVANK VGYINGTFDL VWGNGINTAD MAPLDHTSDK SLLDANFEPG
       130        140        150        160        170        180
KKNFLHLTDK DGEQPQILLE DSSAGEDSVH DRFIGPLPRE GSGGSTSDYV SQSYSYSSIL
       190        200        210        220        230        240
NKSETGYVGL VNQAMTCYLN SLLQTLFMTP EFRNALYKWE FEESEEDPVT SIPYQLQRLF
       250        260        270        280        290        300
VLLQTSKKRA IETTDVTRSF GWDSSEAWQQ HDVQELCRVM FDALEQKWKQ TEQADLINEL
       310        320        330        340        350        360
YQGKLKDYVR CLECGYEGWR IDTYLDIPLV IRPYGSSQAF ASVEEALHAF IQPEILDGPN
       370        380        390        400        410        420
QYFCERCKKK CDARKGLRFL HFPYLLTLQL KRFDFDYTTM HRIKLNDRMT FPEELDMSTF
       430        440        450        460        470        480
IDVEDEKSPQ TESCTDSGAE NEGSCHSDQM SNDFSNDDGV DEGICLETNS GTEKISKSGL
       490        500        510        520        530        540
EKNSLIYELF SVMVHSGSAA GGHYYACIKS FSDEQWYSFN DQHVSRITQE DIKKTHGGSS
       550        560        570        580        590        600
GSRGYYSSAF ASSTNAYMLI YRLKDPARNA KFLEVDEYPE HIKNLVQKER ELEEQEKRQR
       610        620        630        640        650        660
EIERNTCKIK LFCLHPTKQV MMENKLEVHK DKTLKEAVEM AYKMMDLEEV IPLDCCRLVK
       670        680        690        700        710        720
YDEFHDYLER SYEGEEDTPM GLLLGGVKST YMFDLLLETR KPDQVFQSYK PGEVMVKVHV
       730        740        750        760        770        780
VDLKAESVAA PITVRAYLNQ TVTEFKQLIS KAIHLPAETM RIVLERCYND LRLLSVSSKT
       790        800        810        820        830        840
LKAEGFFRSN KVFVESSETL DYQMAFADSH LWKLLDRHAN TIRLFVLLPE QSPVSYSKRT
       850        860        870        880        890        900
AYQKAGGDSG NVDDDCERVK GPVGSLKSVE AILEESTEKL KSLSLQQQQD GDNGDSSKST
       910        920        930        940        950        960
ETSDFENIES PLNERDSSAS VDNRELEQHI QTSDPENFQS EERSDSDVNN DRSTSSVDSD
       970        980        990       1000       1010       1020
ILSSSHSSDT LCNADNAQIP LANGLDSHSI TSSRRTKANE GKKETWDTAE EDSGTDSEYD
      1030       1040       1050       1060       1070       1080
ESGKSRGEMQ YMYFKAEPYA ADEGSGEGHK WLMVHVDKRI TLAAFKQHLE PFVGVLSSHF
      1090       1100       1110       1120       1130       1140
KVFRVYASNQ EFESVRLNET LSSFSDDNKI TIRLGRALKK GEYRVKVYQL LVNEQEPCKF
      1150       1160       1170       1180       1190       1200
LLDAVFAKGM TVRQSKEELI PQLREQCGLE LSIDRFRLRK KTWKNPGTVF LDYHIYEEDI
      1210       1220       1230       1240       1250       1260
NISSNWEVFL EVLDGVEKMK SMSQLAVLSR RWKPSEMKLD PFQEVVLESS SVDELREKLS
      1270       1280       1290       1300       1310       1320
EISGIPLDDI EFAKGRGTFP CDISVLDIHQ DLDWNPKVST LNVWPLYICD DGAVIFYRDK
      1330       1340       1350       1360       1370
TEELMELTDE QRNELMKKES SRLQKTGHRV TYSPRKEKAL KIYLDGAPNK DLTQD         10         20         30         40         50         60
MVPGEENQLV PKEDVFWRCR QNIFDEMKKK FLQIENAAEE PRVLCIIQDT TNSKTVNERI
        70         80         90        100        110        120
TLNLPASTPV RKLFEDVANK VGYINGTFDL VWGNGINTAD MAPLDHTSDK SLLDANFEPG
       130        140        150        160        170        180
KKNFLHLTDK DGEQPQILLE DSSAGEDSVH DRFIGPLPRE GSGGSTSDYV SQSYSYSSIL
       190        200        210        220        230        240
NKSETGYVGL VNQAMTCYLN SLLQTLFMTP EFRNALYKWE FEESEEDPVT SIPYQLQRLF
       250        260        270        280        290        300
VLLQTSKKRA IETTDVTRSF GWDSSEAWQQ HDVQELCRVM FDALEQKWKQ TEQADLINEL
       310        320        330        340        350        360
YQGKLKDYVR CLECGYEGWR IDTYLDIPLV IRPYGSSQAF ASVEEALHAF IQPEILDGPN
       370        380        390        400        410        420
QYFCERCKKK CDARKGLRFL HFPYLLTLQL KRFDFDYTTM HRIKLNDRMT FPEELDMSTF
       430        440        450        460        470        480
IDVEDEKSPQ TESCTDSGAE NEGSCHSDQM SNDFSNDDGV DEGICLETNS GTEKISKSGL
       490        500        510        520        530        540
EKNSLIYELF SVMVHSGSAA GGHYYACIKS FSDEQWYSFN DQHVSRITQE DIKKTHGGSS
       550        560        570        580        590        600
GSRGYYSSAF ASSTNAYMLI YRLKDPARNA KFLEVDEYPE HIKNLVQKER ELEEQEKRQR
       610        620        630        640        650        660
EIERNTCKIK LFCLHPTKQV MMENKLEVHK DKTLKEAVEM AYKMMDLEEV IPLDCCRLVK
       670        680        690        700        710        720
YDEFHDYLER SYEGEEDTPM GLLLGGVKST YMFDLLLETR KPDQVFQSYK PGEVMVKVHV
       730        740        750        760        770        780
VDLKAESVAA PITVRAYLNQ TVTEFKQLIS KAIHLPAETM RIVLERCYND LRLLSVSSKT
       790        800        810        820        830        840
LKAEGFFRSN KVFVESSETL DYQMAFADSH LWKLLDRHAN TIRLFVLLPE QSPVSYSKRT
       850        860        870        880        890        900
AYQKAGGDSG NVDDDCERVK GPVGSLKSVE AILEESTEKL KSLSLQQQQD GDNGDSSKST
       910        920        930        940        950        960
ETSDFENIES PLNERDSSAS VDNRELEQHI QTSDPENFQS EERSDSDVNN DRSTSSVDSD
       970        980        990       1000       1010       1020
ILSSSHSSDT LCNADNAQIP LANGLDSHSI TSSRRTKANE GKKETWDTAE EDSGTDSEYD
      1030       1040       1050       1060       1070       1080
ESGKSRGEMQ YMYFKAEPYA ADEGSGEGHK WLMVHVDKRI TLAAFKQHLE PFVGVLSSHF
      1090       1100       1110       1120       1130       1140
KVFRVYASNQ EFESVRLNET LSSFSDDNKI TIRLGRALKK GEYRVKVYQL LVNEQEPCKF
      1150       1160       1170       1180       1190       1200
LLDAVFAKGM TVRQSKEELI PQLREQCGLE LSIDRFRLRK KTWKNPGTVF LDYHIYEEDI
      1210       1220       1230       1240       1250       1260
NISSNWEVFL EVLDGVEKMK SMSQLAVLSR RWKPSEMKLD PFQEVVLESS SVDELREKLS
      1270       1280       1290       1300       1310       1320
EISGIPLDDI EFAKGRGTFP CDISVLDIHQ DLDWNPKVST LNVWPLYICD DGAVIFYRDK
      1330       1340       1350       1360       1370
TEELMELTDE QRNELMKKES SRLQKTGHRV TYSPRKEKAL KIYLDGAPNK DLTQD

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

9 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q96K76-1-unknown	MVPGEE...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q96K76-1-unknown	MVPGEE...	1		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q96K76-1-unknown	MVPGEE...	1		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q96K76-1-	MVPGEE...	1		Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
Q96K76-1-	MVPGEE...	1		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q96K76-1-	MVPGEE...	1		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q96K76-1-	MVPGEE...	1		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q96K76-1-	MVPGEE...	1		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q96K76-1-	MVPGEE...	1		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q96K76-1-	MVPGEE...	1		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q96K76-1-	MVPGEE...	1		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q96K76-1-	MVPGEE...	1		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q96K76-1-	MVPGEE...	1		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q96K76-132-	GEQPQI...	132		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q96K76-132-unknown	GEQPQI...	132	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173641
Q96K76-849-unknown	SGNVDD...	849	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13082
Q96K76-849-unknown	SGNVDD...	849	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt156314
Q96K76-920-	SVDNRE...	920		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q96K76-920-unknown	SVDNRE...	920	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt171428
Q96K76-1013-unknown	SGTDSE...	1013	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13084
Q96K76-1013-unknown	SGTDSE...	1013	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt156980
Q96K76-1219-unknown	MKSMSQ...	1219	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt93711
Q96K76-1219-unknown	MKSMSQ...	1219	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt96717

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...KAGGDS	848	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13082
...KAGGDS	848	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt139786
...TAEEDS	1012	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13084
...TAEEDS	1012	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140471
...DLTQD	1375	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...DLTQD	1375	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt89329
...DLTQD	1375	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt89328

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	848	GGDS.\|.SGNV	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAB_HUMAN	1012	EEDS.\|.SGTD	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)