Q96MU7: YTH domain-containing protein 1 {ECO:0000305}

General Information

Protein names	- YTH domain-containing protein 1 {ECO:0000305} - Splicing factor YT521 {ECO:0000303\|PubMed:12755701} - YT521-B {ECO:0000303\|PubMed:12755701}
Gene names	YTHDC1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q96MU7

3 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAADSREEKD GELNVLDDIL TEVPEQDDEL YNPESEQDKN EKKGSKRKSD RMESTDTKRQ
        70         80         90        100        110        120
KPSVHSRQLV SKPLSSSVSN NKRIVSTKGK SATEYKNEEY QRSERNKRLD ADRKIRLSSS
       130        140        150        160        170        180
ASREPYKNQP EKTCVRKRDP ERRAKSPTPD GSERIGLEVD RRASRSSQSS KEEVNSEEYG
       190        200        210        220        230        240
SDHETGSSGS SDEQGNNTEN EEEGVEEDVE EDEEVEEDAE EDEEVDEDGE EEEEEEEEEE
       250        260        270        280        290        300
EEEEEEEEEY EQDERDQKEE GNDYDTRSEA SDSGSESVSF TDGSVRSGSG TDGSDEKKKE
       310        320        330        340        350        360
RKRARGISPI VFDRSGSSAS ESYAGSEKKH EKLSSSVRAV RKDQTSKLKY VLQDARFFLI
       370        380        390        400        410        420
KSNNHENVSL AKAKGVWSTL PVNEKKLNLA FRSARSVILI FSVRESGKFQ GFARLSSESH
       430        440        450        460        470        480
HGGSPIHWVL PAGMSAKMLG GVFKIDWICR RELPFTKSAH LTNPWNEHKP VKIGRDGQEI
       490        500        510        520        530        540
ELECGTQLCL LFPPDESIDL YQVIHKMRHK RRMHSQPRSR GRPSRREPVR DVGRRRPEDY
       550        560        570        580        590        600
DIHNSRKKPR IDYPPEFHQR PGYLKDPRYQ EVDRRFSGVR RDVFLNGSYN DYVREFHNMG
       610        620        630        640        650        660
PPPPWQGMPP YPGMEQPPHH PYYQHHAPPP QAHPPYSGHH PVPHEARYRD KRVHDYDMRV
       670        680        690        700        710        720
DDFLRRTQAV VSGRRSRPRE RDRERERDRP RDNRRDRERD RGRDRERERE RLCDRDRDRG

ERGRYRR

Isoforms

- Isoform 2 of YTH domain-containing protein 1

Sequence View

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Physiological Relevance:

Evidence Codes:

Methodology:

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Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q96MU7-1-unknown	MAADSR...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q96MU7-1-unknown	MAADSR...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt94890
Q96MU7-68-unknown	QLVSKP...	68	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14849
Q96MU7-68-unknown	QLVSKP...	68	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt140474
Q96MU7-306-	GISPIV...	306		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q96MU7-306-	GISPIV...	306		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q96MU7-306-	GISPIV...	306		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q96MU7-306-	GISPIV...	306		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SVHSRQ	67	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14849
...SVHSRQ	67	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt123601
...GRYRR	727	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...GRYRR	727	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt90508

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	67	HSRQ.\|.QLVS	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)