Q96PU8: Protein quaking

General Information

Protein names	- Protein quaking - Hqk - HqkI
Gene names	QKI
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q96PU8

9 N-termini

4 C-termini

3 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Protein quaking - Isoform 3 of Protein quaking - Isoform 4 of Protein quaking - Isoform 5 of Protein quaking - Isoform 6 of Protein quaking

Sequence View

        10         20         30         40         50         60
MVGEMETKEK PKPTPDYLMQ LMNDKKLMSS LPNFCGIFNH LERLLDEEIS RVRKDMYNDT
        70         80         90        100        110        120
LNGSTEKRSA ELPDAVGPIV QLQEKLYVPV KEYPDFNFVG RILGPRGLTA KQLEAETGCK
       130        140        150        160        170        180
IMVRGKGSMR DKKKEEQNRG KPNWEHLNED LHVLITVEDA QNRAEIKLKR AVEEVKKLLV
       190        200        210        220        230        240
PAAEGEDSLK KMQLMELAIL NGTYRDANIK SPALAFSLAA TAQAAPRIIT GPAPVLPPAA
       250        260        270        280        290        300
LRTPTPAGPT IMPLIRQIQT AVMPNGTPHP TAAIVPPGPE AGLIYTPYEY PYTLAPATSI
       310        320        330        340
LEYPIEPSGV LGAVATKVRR HDMRVHPYQR IVTADRAATG N         10         20         30         40         50         60
MVGEMETKEK PKPTPDYLMQ LMNDKKLMSS LPNFCGIFNH LERLLDEEIS RVRKDMYNDT
        70         80         90        100        110        120
LNGSTEKRSA ELPDAVGPIV QLQEKLYVPV KEYPDFNFVG RILGPRGLTA KQLEAETGCK
       130        140        150        160        170        180
IMVRGKGSMR DKKKEEQNRG KPNWEHLNED LHVLITVEDA QNRAEIKLKR AVEEVKKLLV
       190        200        210        220        230        240
PAAEGEDSLK KMQLMELAIL NGTYRDANIK SPALAFSLAA TAQAAPRIIT GPAPVLPPAA
       250        260        270        280        290        300
LRTPTPAGPT IMPLIRQIQT AVMPNGTPHP TAAIVPPGPE AGLIYTPYEY PYTLAPATSI
       310        320        330        340
LEYPIEPSGV LGAVATKVRR HDMRVHPYQR IVTADRAATG N         10         20         30         40         50         60
MVGEMETKEK PKPTPDYLMQ LMNDKKLMSS LPNFCGIFNH LERLLDEEIS RVRKDMYNDT
        70         80         90        100        110        120
LNGSTEKRSA ELPDAVGPIV QLQEKLYVPV KEYPDFNFVG RILGPRGLTA KQLEAETGCK
       130        140        150        160        170        180
IMVRGKGSMR DKKKEEQNRG KPNWEHLNED LHVLITVEDA QNRAEIKLKR AVEEVKKLLV
       190        200        210        220        230        240
PAAEGEDSLK KMQLMELAIL NGTYRDANIK SPALAFSLAA TAQAAPRIIT GPAPVLPPAA
       250        260        270        280        290        300
LRTPTPAGPT IMPLIRQIQT AVMPNGTPHP TAAIVPPGPE AGLIYTPYEY PYTLAPATSI
       310        320        330        340
LEYPIEPSGV LGAVATKVRR HDMRVHPYQR IVTADRAATG N         10         20         30         40         50         60
MVGEMETKEK PKPTPDYLMQ LMNDKKLMSS LPNFCGIFNH LERLLDEEIS RVRKDMYNDT
        70         80         90        100        110        120
LNGSTEKRSA ELPDAVGPIV QLQEKLYVPV KEYPDFNFVG RILGPRGLTA KQLEAETGCK
       130        140        150        160        170        180
IMVRGKGSMR DKKKEEQNRG KPNWEHLNED LHVLITVEDA QNRAEIKLKR AVEEVKKLLV
       190        200        210        220        230        240
PAAEGEDSLK KMQLMELAIL NGTYRDANIK SPALAFSLAA TAQAAPRIIT GPAPVLPPAA
       250        260        270        280        290        300
LRTPTPAGPT IMPLIRQIQT AVMPNGTPHP TAAIVPPGPE AGLIYTPYEY PYTLAPATSI
       310        320        330        340
LEYPIEPSGV LGAVATKVRR HDMRVHPYQR IVTADRAATG N         10         20         30         40         50         60
MVGEMETKEK PKPTPDYLMQ LMNDKKLMSS LPNFCGIFNH LERLLDEEIS RVRKDMYNDT
        70         80         90        100        110        120
LNGSTEKRSA ELPDAVGPIV QLQEKLYVPV KEYPDFNFVG RILGPRGLTA KQLEAETGCK
       130        140        150        160        170        180
IMVRGKGSMR DKKKEEQNRG KPNWEHLNED LHVLITVEDA QNRAEIKLKR AVEEVKKLLV
       190        200        210        220        230        240
PAAEGEDSLK KMQLMELAIL NGTYRDANIK SPALAFSLAA TAQAAPRIIT GPAPVLPPAA
       250        260        270        280        290        300
LRTPTPAGPT IMPLIRQIQT AVMPNGTPHP TAAIVPPGPE AGLIYTPYEY PYTLAPATSI
       310        320        330        340
LEYPIEPSGV LGAVATKVRR HDMRVHPYQR IVTADRAATG N

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

9 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q96PU8-1-unknown	MVGEME...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q96PU8-1-unknown	MVGEME...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt86746
Q96PU8-1-unknown	MVGEME...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt86747
Q96PU8-1-unknown	MVGEME...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt86748
Q96PU8-1-unknown	MVGEME...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt86749
Q96PU8-1-unknown	MVGEME...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt86750
Q96PU8-1-unknown	MVGEME...	1		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q96PU8-1-	MVGEME...	1		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q96PU8-1-	MVGEME...	1		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q96PU8-36-unknown	GIFNHL...	36	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4199
Q96PU8-36-unknown	GIFNHL...	36	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt138025
Q96PU8-36-unknown	GIFNHL...	36	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt138026
Q96PU8-36-unknown	GIFNHL...	36	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt138028
Q96PU8-36-unknown	GIFNHL...	36	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt138030
Q96PU8-36-unknown	GIFNHL...	36	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt138031
Q96PU8-75-	AVGPIV...	75		Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
Q96PU8-75-	AVGPIV...	75		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q96PU8-75-	AVGPIV...	75		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q96PU8-75-	AVGPIV...	75		Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
Q96PU8-75-	AVGPIV...	75		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q96PU8-75-unknown	AVGPIV...	75	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt164760
Q96PU8-75-unknown	AVGPIV...	75	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt164761
Q96PU8-75-unknown	AVGPIV...	75	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt164762
Q96PU8-75-unknown	AVGPIV...	75	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt164763
Q96PU8-75-unknown	AVGPIV...	75	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt164764
Q96PU8-195-unknown	MELAIL...	195	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14852
Q96PU8-195-unknown	MELAIL...	195	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146415
Q96PU8-195-unknown	MELAIL...	195	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146416
Q96PU8-195-unknown	MELAIL...	195	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146417
Q96PU8-217-unknown	SLAATA...	217		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q96PU8-217-unknown	SLAATA...	217	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt160093
Q96PU8-217-unknown	SLAATA...	217	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt160094
Q96PU8-217-unknown	SLAATA...	217	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt160095
Q96PU8-217-	SLAATA...	217		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q96PU8-219-unknown	AATAQA...	219	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14858
Q96PU8-219-unknown	AATAQA...	219	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt147300
Q96PU8-219-unknown	AATAQA...	219	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt147301
Q96PU8-219-unknown	AATAQA...	219	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt147302

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LPNFCG	35	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4199
...LPNFCG	35	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt121041
...LPNFCG	35	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt121042
...LPNFCG	35	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt121044
...LPNFCG	35	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt121046
...LPNFCG	35	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt121047
...KKMQLM	194	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14852
...KKMQLM	194	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129720
...KKMQLM	194	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129721
...KKMQLM	194	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129722
...KKMQLM	194	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129723
...KKMQLM	194	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129724
...LAFSLA	218	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14858
...LAFSLA	218	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130643
...LAFSLA	218	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130644
...LAFSLA	218	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130645
...AATGN	341	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...AATGN	341	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt82364

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATB_HUMAN	35	NFCG.\|.GIFN	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAM_HUMAN	194	MQLM.\|.MELA	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAM_HUMAN	218	FSLA.\|.AATA	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)