Q96RE7: Nucleus accumbens-associated protein 1

General Information

Protein names	- Nucleus accumbens-associated protein 1 - NAC-1 - BTB/POZ domain-containing protein 14B
Gene names	NACC1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q96RE7

5 N-termini

3 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAQTLQMEIP NFGNSILECL NEQRLQGLYC DVSVVVKGHA FKAHRAVLAA SSSYFRDLFN
        70         80         90        100        110        120
NSRSAVVELP AAVQPQSFQQ ILSFCYTGRL SMNVGDQFLL MYTAGFLQIQ EIMEKGTEFF
       130        140        150        160        170        180
LKVSSPSCDS QGLHAEEAPS SEPQSPVAQT SGWPACSTPL PLVSRVKTEQ QESDSVQCMP
       190        200        210        220        230        240
VAKRLWDSGQ KEAGGGGNGS RKMAKFSTPD LAANRPHQPP PPQQAPVVAA AQPAVAAGAG
       250        260        270        280        290        300
QPAGGVAAAG GVVSGPSTSE RTSPGTSSAY TSDSPGSYHN EEDEEEDGGE EGMDEQYRQI
       310        320        330        340        350        360
CNMYTMYSMM NVGQTAEKVE ALPEQVAPES RNRIRVRQDL ASLPAELINQ IGNRCHPKLY
       370        380        390        400        410        420
DEGDPSEKLE LVTGTNVYIT RAQLMNCHVS AGTRHKVLLR RLLASFFDRN TLANSCGTGI
       430        440        450        460        470        480
RSSTNDPRRK PLDSRVLHAV KYYCQNFAPN FKESEMNAIA ADMCTNARRV VRKSWMPKVK
       490        500        510        520
VLKAEDDAYT TFISETGKIE PDMMGVEHGF ETASHEGEAG PSAEALQ

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

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Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

5 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q96RE7-1-unknown	MAQTLQ...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q96RE7-2-acetylation	AQTLQM...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q96RE7-308-	SMMNVG...	308			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q96RE7-308-	SMMNVG...	308			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q96RE7-321-	ALPEQV...	321			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q96RE7-321-	ALPEQV...	321			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q96RE7-340-unknown	LASLPA...	340		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13111

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PLVSRV	165	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000467120
...RVRQDL	339	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13111
...AEALQ	527	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	339	RQDL.\|.LASL	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)