Q96S44: EKC/KEOPS complex subunit TP53RK {ECO:0000305}

General Information

Protein names	- EKC/KEOPS complex subunit TP53RK {ECO:0000305} - 3.6.-.- {ECO:0000250\|UniProtKB:Q9UYB9} - Atypical serine/threonine protein kinase TP53RK - Nori-2 - TP53-regulating kinase - 2.7.11.1 {ECO:0000269\|PubMed:11546806} - p53-related protein kinase {ECO:0000303\|PubMed:11546806}
Gene names	TP53RK
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q96S44

4 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAAARATTPA DGEEPAPEAE ALAAARERSS RFLSGLELVK QGAEARVFRG RFQGRAAVIK
        70         80         90        100        110        120
HRFPKGYRHP ALEARLGRRR TVQEARALLR CRRAGISAPV VFFVDYASNC LYMEEIEGSV
       130        140        150        160        170        180
TVRDYIQSTM ETEKTPQGLS NLAKTIGQVL ARMHDEDLIH GDLTTSNMLL KPPLEQLNIV
       190        200        210        220        230        240
LIDFGLSFIS ALPEDKGVDL YVLEKAFLST HPNTETVFEA FLKSYSTSSK KARPVLKKLD
       250
EVRLRGRKRS MVG

Isoforms

Sequence View

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Physiological Relevance:

Evidence Codes:

Methodology:

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Biological System:

Protease Assignment Confidence:

Evidence Names:

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Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q96S44-1-unknown	MAAARA...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q96S44-6-	ATTPAD...	6		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q96S44-6-	ATTPAD...	6		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q96S44-6-unknown	ATTPAD...	6	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10493
Q96S44-12-	GEEPAP...	12		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...MAAARA	5	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10493
	...RSMVG	253	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAA_HUMAN	5	AARA.\|.ATTP	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)