Q96SB3: Neurabin-2

General Information

Protein names	- Neurabin-2 - Neurabin-II - Protein phosphatase 1 regulatory subunit 9B - Spinophilin
Gene names	PPP1R9B
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q96SB3

20 N-termini

17 C-termini

16 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MMKTEPRGPG GPLRSASPHR SAYEAGIQAL KPPDAPGPDE APKGAHHKKY GSNVHRIKSM
        70         80         90        100        110        120
FLQMGTTAGP SGEAGGGAGL AEAPRASERG VRLSLPRASS LNENVDHSAL LKLGTSVSER
       130        140        150        160        170        180
VSRFDSKPAP SAQPAPPPHP PSRLQETRKL FERSAPAAAG GDKEAAARRL LRQERAGLQD
       190        200        210        220        230        240
RKLDVVVRFN GSTEALDKLD ADAVSPTVSQ LSAVFEKADS RTGLHRGPGL PRAAGVPQVN
       250        260        270        280        290        300
SKLVSKRSRV FQPPPPPPPA PSGDAPAEKE RCPAGQQPPQ HRVAPARPPP KPREVRKIKP
       310        320        330        340        350        360
VEVEESGESE AESAPGEVIQ AEVTVHAALE NGSTVATAAS PAPEEPKAQA APEKEAAAVA
       370        380        390        400        410        420
PPERGVGNGR APDVAPEEVD ESKKEDFSEA DLVDVSAYSG LGEDSAGSAL EEDDEDDEED
       430        440        450        460        470        480
GEPPYEPESG CVEIPGLSEE EDPAPSRKIH FSTAPIQVFS TYSNEDYDRR NEDVDPMAAS
       490        500        510        520        530        540
AEYELEKRVE RLELFPVELE KDSEGLGISI IGMGAGADMG LEKLGIFVKT VTEGGAAHRD
       550        560        570        580        590        600
GRIQVNDLLV EVDGTSLVGV TQSFAASVLR NTKGRVRFMI GRERPGEQSE VAQLIQQTLE
       610        620        630        640        650        660
QERWQREMME QRYAQYGEDD EETGEYATDE DEELSPTFPG GEMAIEVFEL AENEDALSPV
       670        680        690        700        710        720
DMEPEKLVHK FKELQIKHAV TEAEIQQLKR KLQSLEQEKG RWRVEKAQLE QSVEENKERM
       730        740        750        760        770        780
EKLEGYWGEA QSLCQAVDEH LRETQAQYQA LERKYSKAKR LIKDYQQKEI EFLKKETAQR
       790        800        810
RVLEESELAR KEEMDKLLDK ISELEGNLQT LRNSNST

Isoforms

Sequence View

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Evidence Names:

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Protein Neighborhood

Domains & Features

20 N-termini - 17 C-termini - 16 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q96SB3-1-unknown	MMKTEP...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q96SB3-1-acetylation	MMKTEP...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q96SB3-126-	SKPAPS...	126			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q96SB3-201-unknown	ADAVSP...	201		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2738
Q96SB3-379-unknown	VDESKK...	379		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2739
Q96SB3-390-unknown	ADLVDV...	390		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2740
Q96SB3-412-unknown	EDDEDD...	412		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2741
Q96SB3-413-unknown	DDEDDE...	413		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2742
Q96SB3-415-unknown	EDDEED...	415		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2743
Q96SB3-416-unknown	DDEEDG...	416		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2744
Q96SB3-419-unknown	EDGEPP...	419		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2745
Q96SB3-441-unknown	EDPAPS...	441		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2746
Q96SB3-467-unknown	YDRRNE...	467		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2747
Q96SB3-474-unknown	VDPMAA...	474		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2748
Q96SB3-501-unknown	KDSEGL...	501		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2749
Q96SB3-552-	VDGTSL...	552			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q96SB3-552-	VDGTSL...	552			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q96SB3-552-	VDGTSL...	552			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q96SB3-552-	VDGTSL...	552			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q96SB3-552-unknown	VDGTSL...	552		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2750
Q96SB3-619-unknown	DDEETG...	619		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2751
Q96SB3-630-unknown	EDEELS...	630		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2752
Q96SB3-794-unknown	MDKLLD...	794		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2753

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LDKLDA	200	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2738
...VAPEEV	378	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2739
...EDFSEA	389	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2740
...GSALEE	411	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2741
...SALEED	412	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2742
...LEEDDE	414	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2743
...EEDDED	415	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2744
...DEDDEE	418	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2745
...GLSEEE	440	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2746
...YSNEDY	466	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2747
...RRNEDV	473	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2748
...PVELEK	500	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2749
...DLLVEV	551	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2750
...AQYGED	618	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2751
...EYATDE	629	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2752
...ARKEEM	793	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2753
...LRNSNS	815	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP6_HUMAN	200	KLDA.\|.ADAV	inferred from experiment	unknown	MEROPS	Leblanc AC	Klaiman G et al.:Targets of caspase-6 activity i... (C14.005)	18487604,
CASP6_HUMAN	378	PEEV.\|.VDES	inferred from experiment	unknown	MEROPS	Leblanc AC	Klaiman G et al.:Targets of caspase-6 activity i... (C14.005)	18487604,
CASP6_HUMAN	389	FSEA.\|.ADLV	inferred from experiment	unknown	MEROPS	Leblanc AC	Klaiman G et al.:Targets of caspase-6 activity i... (C14.005)	18487604,
CASP6_HUMAN	411	ALEE.\|.EDDE	inferred from experiment	unknown	MEROPS	Leblanc AC	Klaiman G et al.:Targets of caspase-6 activity i... (C14.005)	18487604,
CASP6_HUMAN	412	LEED.\|.DDED	inferred from experiment	unknown	MEROPS	Leblanc AC	Klaiman G et al.:Targets of caspase-6 activity i... (C14.005)	18487604,
CASP6_HUMAN	414	EDDE.\|.EDDE	inferred from experiment	unknown	MEROPS	Leblanc AC	Klaiman G et al.:Targets of caspase-6 activity i... (C14.005)	18487604,
CASP6_HUMAN	415	DDED.\|.DDEE	inferred from experiment	unknown	MEROPS	Leblanc AC	Klaiman G et al.:Targets of caspase-6 activity i... (C14.005)	18487604,
CASP6_HUMAN	418	DDEE.\|.EDGE	inferred from experiment	unknown	MEROPS	Leblanc AC	Klaiman G et al.:Targets of caspase-6 activity i... (C14.005)	18487604,
CASP6_HUMAN	440	SEEE.\|.EDPA	inferred from experiment	unknown	MEROPS	Leblanc AC	Klaiman G et al.:Targets of caspase-6 activity i... (C14.005)	18487604,
CASP6_HUMAN	466	NEDY.\|.YDRR	inferred from experiment	unknown	MEROPS	Leblanc AC	Klaiman G et al.:Targets of caspase-6 activity i... (C14.005)	18487604,
CASP6_HUMAN	473	NEDV.\|.VDPM	inferred from experiment	unknown	MEROPS	Leblanc AC	Klaiman G et al.:Targets of caspase-6 activity i... (C14.005)	18487604,
CASP6_HUMAN	500	ELEK.\|.KDSE	inferred from experiment	unknown	MEROPS	Leblanc AC	Klaiman G et al.:Targets of caspase-6 activity i... (C14.005)	18487604,
CASP6_HUMAN	551	LVEV.\|.VDGT	inferred from experiment	unknown	MEROPS	Leblanc AC	Klaiman G et al.:Targets of caspase-6 activity i... (C14.005)	18487604,
CASP6_HUMAN	618	YGED.\|.DDEE	inferred from experiment	unknown	MEROPS	Leblanc AC	Klaiman G et al.:Targets of caspase-6 activity i... (C14.005)	18487604,
CASP6_HUMAN	629	ATDE.\|.EDEE	inferred from experiment	unknown	MEROPS	Leblanc AC	Klaiman G et al.:Targets of caspase-6 activity i... (C14.005)	18487604,
CASP6_HUMAN	793	KEEM.\|.MDKL	inferred from experiment	unknown	MEROPS	Leblanc AC	Klaiman G et al.:Targets of caspase-6 activity i... (C14.005)	18487604,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)